Sentences with phrase «normal cells grow»

Normal cells grow and die in a controlled way.

Normal cells grow, divide, and die naturally.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

Normal cells grown in culture have a limited potential to divide and eventually become terminally non-dividing.

Not exact matches

Multiple myeloma causes tumors to grow in the bone marrow, preventing the production of normal blood cells.

With microRNA - 210 in check, cells regain their normal function and cancer can not grow.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

Changes in the normal function of Ras proteins — mutations which are responsible for 30 percent of all cancers — can power cancer cells to grow and spread.

Measuring a few millimetres across, the pieces of intestinal tissue made by the month - long process contain all the cells and features found in normal gut tissue, and grow by the same route as in embryos.

Cancer cells may produce unique metabolic profiles, in part because they grow very rapidly and have metabolic activity very different from normal cells.

Matteo Boretto, the first author on this study, commented that «we were very excited to see that we could not only robustly grow and amplify endometrial tissue in a dish, but that the tiny structures were also able to reproduce normal responses of the endometrium to hormones: oestrogen makes the tissue thicken, progesterone then induces maturation including folding (see picture), and subsequent removal of both hormones mimics the cell shedding of the menstrual period.»

In abnormal [PSI +] cells, which are genetically identical to normal cells, the important protein clumps together, and the cells are unable to grow under certain conditions.

When the stress has passed, the number of misfolded proteins drops, the enzyme Lon would stop destroying the normal protein, and cells would start growing again, the authors found.

For tumors to grow and spread, cancer cells must make larger than normal amounts of nucleic acids and protein, so they can replicate themselves.

«We need to know how taste cells grow and work in normal situations before we can harness this knowledge to help people.»

The team reports that the adenomas grow from cells that express a gene called Lgr5 +, which is also active in normal intestinal stem cells.

As a result of this careful debugging, yeast cells with the synthetic chromosomes grow just as quickly in the lab as normal, wild yeast, despite the wholesale alterations (Science, DOI: 10.1126 / science.aaf4557).

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

These immortal precursor cells could then be «grown up» in petri dishes and differentiated into normal fat cells.

«We know that the pathway is important for normal cells to carry their activities as it is involved in regulating metabolism, that is, how cells process nutrients to obtain energy and how cells use energy to grow.

Today, Cold Spring Harbor Laboratory (CSHL) and The Lustgarten Foundation jointly announce the development of a new model system to grow both normal and cancerous pancreatic cells in the laboratory.

As controls, fibroblasts and secretions from normal lab rats, mice, and another rodent called the spiny mouse were powerless to stop the human cancer cells growing.

Interestingly, the outbreak strain grew at a normal pace in cultured human white blood cells, apparently by subverting the immune response to its benefit.

All cancer research relies on a steady supply of cells — both normal and cancerous — that can be grown in the laboratory.

Sure enough, the researchers report, the cells without the variation now grew the normal amount of synapses, while those with the inserted mutation had half as many.

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.

When transplanted into rats with hypopituitarism — a disease linked to dwarfism and premature aging in humans — the lab - grown pituitary cells promoted normal hormone release.

This inflammation is important in the normal healing process, affecting tissue growth and blood flow changes that allow the tissue to heal; when the inflammation subsides, skin cells start growing to cover the wound and help the tissue knit together.

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number.»

The adapted cells outcompeted the normal ones and grew about three times as many colonies.

In normal cells, the mTOR pathway can be turned on and off, but in some cancers mTOR becomes impossible to switch off, and the cells are left to grow without any regulation.

Cells with these mutations formed clusters of cells, known as clones, that had grown to be around twice the size of normal clones, but none of them had become canceCells with these mutations formed clusters of cells, known as clones, that had grown to be around twice the size of normal clones, but none of them had become cancecells, known as clones, that had grown to be around twice the size of normal clones, but none of them had become cancerous.

But a recent report that her telomeres — the tips of chromosomes, which tend to shrink as cells grow older — are shorter than normal for her age suggests that her life span might be reduced.

The cells with the normal gene grew significantly longer dendrites — the portions of the cell that reach out to receive nerve impulses — than did neurons with the mutated gene, the team reports 14 October in Science.

Christofk studies the genes and proteins behind the way cancer cells use sugars to live and grow, which is different from how normal cells do.

Because AML grows rapidly, it can quickly crowd out normal blood cells, leading to anemia, susceptibility to infections and uncontrolled bleeding.

As cells grow and multiply, by chance there can be uneven distribution of normal vs. abnormal DNA to different cells.

Insulin is a key ingredient for the growth and proliferation of normal stem cells, and the study demonstrated that insulin resistance also reduces the ability of the iPSCs to grow and proliferate.

Clarke notes that this kind of work — reprogramming normal cells to replace damaged tissues or organs in regenerative medicine, or even growing cells from an individual's cancer to determine what the best treatment is — speaks to the doctrine rather than challenges it.

The egg cell grew into a normal frog, genetically identical to the tadpole.

To be able to grow a patient's cancer and compare it with genetically normal neural stem cells is a really special tool.

Young said Celltex did a study in which it injected lab mice with 73 times the normal dose of 200 million cells that Celltex gives its clients, and none of the mice died, developed toxic organs or grew tumors.

When the researchers eliminated both BRCA1 and p53, they found the neurons grew at a normal rate, but still disorderly, with cells pointed in the wrong direction.

These antibodies can identify substances on cancer cells or normal substances that may help cancer cells grow.

By adding an inhibitor of the WNT pathway to the growing DISC1 - mutant mini-brains, the researchers were able to «rescue» them - instead of having structural differences, they looked similar to the mini-brains developed from normal stem cells.

The research, published online on April 18 in the journal Lab on a Chip, describes the successful recording of both electrical signals and cellular beating from normal human heart cells grown on a multi-electrode array developed at the Lab.

culture (in microbiology) To grow cells outside the body or their normal environment, usually in a beaker, a laboratory dish or some big vessel.

Normal human lung fibroblasts (NHLF) cells grown in 384 - well Optilux plates were treated with candidate compounds and incubated for 18 hours prior to fixation and staining with Hoescht dye and anti-HMOX1 antibody as described in Materials and Methods.

culture (v. in microbiology) To grow cells outside the body or their normal environment, usually in a beaker, a laboratory dish or some big vessel.

Morphologically the majority of V + cells grown in the presence of LIF appear indistinguishable from their V − counterparts and the level of fluorescence in these morphologically normal V + cells is substantially lower than that observed in cells that either appear differentiated or have been differentiated in response to LIF withdrawal (Figure 2B).