Sentences with phrase «normal mice produced»

Normal mice produced more than four times more melanocytes than did the p53 «knockout» mice.

In that time, the normal mice produced regularly, giving birth to a litter of seven or eight pups approximately every 21 days, for a total of about 60 baby mice.

Not exact matches

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

Damaged mouse sciatic nerves produced hundreds of times the normal amount of two «chemoattractant» molecules, Cxcl1 and Cxcl2, which attach to the surfaces of neutrophils and draw the immune cells into injured tissue.

Using the refrigerated sperm, the researchers were able to fertilize an egg in vitro and produce a normal mouse pup.

Uhl and crew then produced mice that had half the normal number of opiate receptors and as a result, experienced greater discomfort when exposed to a standard mildly painful stimulus.

When they examined mice genetically incapable of producing Helios, they found the animals beset by a T - cell and antibody attack on normal tissue.

In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cells.

That's because the boosted mice produced normal — rather than high — levels of the amyloid precursor proteins from which plaques are made.

Six pairs of mice — with one mouse engineered to produce gobs of human A-beta and one normal — were surgically joined for a year, causing blood mingling that's far more extensive than that of a blood transfusion.

In a study published October 30 in Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritants.

But the males — despite having smaller testes and lower sperm counts than normal mice — were clearly fertile and produced offspring.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.

The researchers studied both normal mice and mice genetically engineered without the Trpv4 gene (which produces TRPV4 channel protein).

In contrast, M49, a less virulent strain of strep, caused larger skin lesions in mice lacking cathelicidin than in normal, cathelicidin - producing mice.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

In normal mice with working photoreceptors (PR driven), stimulating the retina produces a variety of responses in retinal ganglion cells, the output of the eye.

Photoswitches inserted into retinal ganglion cells (RGC) of blind mice produce much less variety of response (all evenly red means the cells fire at the same time), while blind mice with photoswitches inserted into bipolar cells (ON - BC driven) exhibit much more variety in their retinal response to light, closer to that of normal mice.

(Normal and engineered mice produced the same volume of urine.)

Since more Cx43 means less room in the bladder, the team speculates that although normal mice didn't stop producing urine when asleep, their bladders were able to hold more due to decreased Cx43 concentrations.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

Mice genetically engineered not to produce a key cytokine (TNF - alpha) fared no better than normal mice during infectiMice genetically engineered not to produce a key cytokine (TNF - alpha) fared no better than normal mice during infectimice during infections.

KLF15 - deficient mice produced 40 to 50 percent less bile acid than normal mice, making them less capable of absorbing the lipids and the nutrients they contained.

The researchers found that levels of a substance called 4 - ethylphenylsulfate that is produced by gut bacteria increased 46-fold in the mice with autistic symptoms, but returned to normal after treatment with B. fragilis.

In the normal mice, UV treatment doubled the amount of KITLG produced, whereas the p53 knockouts couldn't produce any.

He notes, however, that other attempts to stimulate bone growth in mice by manipulating cell signaling proteins have produced denser than normal bones — and he's surprised that Helms's team didn't see the same.

In another experiment, mice lacking the cells that produce serotonin scratched less than normal mice when exposed to a skin irritant.

The acrosome, a structure essential for fertilization, appears as a green, moon - shaped cap on normal sperm (left), but is missing or misshapen on sperm produced by mice treated with NB - DNJ (right).

The researchers found that in genetically - modified mice lacking Interferon - 1, who were also fed a high - fat diet, the CD8 + T cells did not produce an inflammatory response, and the mice had near normal blood sugar levels.

But Hecht notes that although CNP breaks down within minutes in the body, decoy FGFR3 lasts for hours and produces normal growth in the mice with just twice - weekly injections.

As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right).

Dr. Verdin further found that prolonged intake of a high - fat diet, even in normal mice, can itself reduce the activity of the enzyme produced by SIRT3 — an enzyme his laboratory originally discovered.

Allergic airway hyperresponsiveness - enhancing γ $ ẹlta $ T cells develop in normal untreated mice and fail to produce IL - 4 / 13, unlike Th2 and NKT cells.

When the sperm then fertilises a normal egg, a transgenic mouse is produced with the same foreign DNA in every cell.

AHR - Enhancing γ $ ẹlta $ T Cells Develop in Normal Untreated Mice and Fail to Produce IL - 4 / 13, Unlike TH2 Cells and NKT Cells.

When normal mice were exposed to TNF, all tissues studied (liver, kidney, spleen, thymus, colon, and lymph nodes) produced large amounts of A20 and the mice survived unharmed.

Researchers comparing normal and obese mice found that obese mice produced more than twice as much of a small microRNA molecule called microRNA - 143 in their liversANCHOR.

She observed that the repertoire of immune cell subtypes differed between normal and engineered mice, and furthermore, that T cells of engineered mice fed a «western» (fatty) diet produced inordinately high levels of pro-inflammatory cytokines.

Takeda et al. engineered mice that were either unable to produce a particular LPA receptor on their T - cells, or that produced less LPA than normal.

Conversely, mice genetically engineered to produce less insulin had healthier fat cells, burned off more calories, and resisted weight gain, even when given a diet that makes normal mice fat.

The reason for this response, Gordon says, was twofold: Firmicutes bacteria transplanted from the fat mice produced more of the enzymes that helped the animals extract more energy from their food, and the bacteria also manipulated the genes of the normal mice in ways that triggered the storage of fat rather than its breakdown for energy.