Sentences with phrase «novel on connectivity»

According to the study «Short - and Long - Term Effects of a Novel on Connectivity in the Brain,» by Emory University researchers Gregory S. Berns, Kristina Blaine, Michael J. Prietula, and Brandon E. Pye, reading a novel causes recordable, distinct... [Read more...]

According to the study «Short - and Long - Term Effects of a Novel on Connectivity in the Brain,» by Emory University researchers Gregory S. Berns, Kristina Blaine, Michael J. Prietula, and Brandon E. Pye, reading a novel causes recordable, distinct physiological changes in the reader's brain.

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To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.