Sentences with phrase «novel regulation of gene»

Not exact matches

Following this in 2015, an article (Alsaweed et al.) described over 300 novel milk microRNA molecules, components that are known to play a key role in the regulation of gene expression.

We are also establishing novel functional strategies, based on targeted and high throughput reporter assays, to assess the relevance of the spatial environment on gene regulation.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

His fundamental work has provided novel insights into the mechanisms of epigenetic gene regulation.

We identified and characterized a novel member of the forkhead gene family that is essential for proper regulation of satellite cells.

We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.

With her recent groundbreaking findings in the field of RNA - mediated regulation based on the CRISPR - Cas9 system, E. Charpentier has laid the foundation for the development of a novel, highly versatile and specific genome editing technology that is revolutionizing life sciences research and could open up whole new opportunities in biomedical gene therapies.

Finally, we will conduct an RNAi based screen to identify novel factors that are involved in the regulation of sestrin gene expression and that may act in conjunction with p53.

The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene - expression in single cells.

We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole - blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources.

Our recent research has provided a novel direction in the biology of these cancers — that abnormal patterns of regulation of certain non-coding RNA (ncRNA) and microRNA genes determine aggressiveness of these cancers.

Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms.