Sentences with phrase «nucleic acids res»

Cheng HM, Gröger P, Hartmann A, Schlierf M. Nucleic Acids Res.

Target information above from: UniProt accession Q9UBK2 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res.

Target information above from: UniProt accession P46013 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res.

Design and synthesis of fluorescent substrates for human tyrosyl - DNA phosphodiesterase I. Nucleic Acids Res.

Nucleic Acids Res 2015 Jan 28; 43: D97 - D102

Nucleic Acids Res 2008; 36: D149 — D153.

In the meantime, Baojin Yao, postdoctoral fellow, focused on identifying mechanisms controlling the expression of the SOX9 gene in chondrocytes (Yao et al., Nucleic Acids Res., 2015).

Nucleic Acids Res, doi: 10.1093 / nar / gks905 (2012)

FINDINGS The researchers identified 32 known imprinted genes, but no new ones, implying that the list of imprinted genes in the mouse — at least in embryonic fibroblasts — is nearly complete, says Morison, who was not involved in the study (Nucleic Acids Res, 42:1772 - 83, 2014).

Felicori L, Jameson KH, et al., Nucleic Acids Res.

Shi, X., Hanson, M.R., and Bentolila S. (2015) Two RNA recognition motif - containing proteins are plant mitochondrial editing factors Nucleic Acids Res 43:3814 - 3825

Nucleic Acids Res 29, 1507 - 1513.

Abi - Ghanem J, Chusainow J, Karimova M, Spiegel C, Hofmann - Sieber H, Hauber J, Buchholz F, Pisabarro MT. Nucleic Acids Res.

The probablility of all the cellular machinery (enzymes, ion channels, RNA polymerase, anabolic and catabolic pathways, etc) just assembling out of randomn peptides and nucleic acids is infinitely small.

Nucleic acids are also helping scientists to detect biomarkers, such as Abcam's Fireplex (formerly Firefly) particle technology, which profiles biomarker microRNAs (miRNAs) directly from biofluid samples, without RNA purification.

Nucleic acids are the building blocks of all living organisms and they encode, transmit and express genetic information.

It was not until the polymerase chain reaction technique for amplifying nucleic acids was developed in the late - 1980s that it became possible to do anything with the tiny and fragmentary biochemical evidence from insects embedded in amber.

Most of the prize money will go to new research and a company party, but CureVac also plans to use some of it to build an exhibit honoring Friedrich Miescher, a 19th century Swiss scientist whose discovery of nucleic acids isn't widely known.

The purified nucleic acids are then combined with RPA primers and enzymes tuned to amplify the pathogen of interest, Crannell said.

«The classical concept is that nucleic acid is not able to pass through the mammalian placenta, while we have also demonstrated that MV - driven small RNAs are able to pass through placenta,» Zhang said.

Proteins, fatty acids, and nucleic acids are essential factors for cell survival using glutamine metabolism.

The origin of life is not the same as the origin of its constituent building blocks, but laboratory studies on the linking of amino acids into molecules resembling proteins and on the linking of nucleotides into molecules resembling nucleic acids are progressing well.

Extracted nucleic acid was amplified using a random PCR method to generate cDNA libraries for Virochip and deep sequencing analyses as previously described [18], [21].

Reverse transfection — the method whereby nucleic acids are localized on a substrate prior to addition of cells — was first developed in 2001 at Whitehead Institute for Biomedical Research by Junald Ziauddin and David M. Sabatini.

Nucleic acids are not only key molecules for the storage, replication and transcription of genetic information, but also serve as enzymes or regulators of a number of cell processes.

Microbial nucleic acids are generally not directly accessible to cell surface receptors.

Not exact matches

Says Roberts: «He quickly figured out that if Illumina was successful, it would need more than the world's supply of oligonucleotides» — the short snippets of nucleic acid that are designed to pair up with specific genetic sequences, and which are critical for DNA or RNA analysis.

One way to shut down the communication link is through a snippet of RNA called «antisense» — which binds to the messenger RNA (a «sense» - making strip of nucleic acids) that is transcribed by a given stretch of DNA.

What happens when we replace the four building blocks of DNA with six — that is to say, the four nucleic acids that have stood through billions of years of evolution plus two new versions that came out of a San Diego lab last year?

According to one of his analogies: just as the sequence of letters on a page is extraneous to the chemistry of ink and paper, so the sequence of nucleic acids in the DNA molecule (which, when translated, determines the shape of an organism and its specific characteristics) is extraneous to the chemical forces operative in the genetic process.

Were there not a certain invariance about the way in which carbon atoms bond with others under identical conditions, or about the manner in which protein synthesis is charted and activated by nucleic acids, life would be impossible altogether.

Still is it not possible that the specific sequence of base - pairs in a DNA molecule is extraneous to the chemistry which bonds the nucleic acids to one another?

The letters of this code are nucleic acids (A, C, T and G) arranged sequentially in triadic formations.

Out of the Gordon Conference on nucleic acids in the summer of 1973 came an open letter to Science; the establishment (in October 1974) by the National Institutes of Health of the Recombinant DNA Molecule Program Advisory Committee; and in February 1975 the now - famous international conference at the Asilomar Conference Center in California, where a reluctant decision was made by scientists to declare a temporary moratorium on certain kinds of DNA research.

it is there for very easy to expect that 3.5 - 4 billion years ago there were pools of water full of self replicating nucleic acids.

Nucleotides and amino acids are substances which, there is reason to believe, could have been formed, and polymerized into nucleic acid and protein respectively, under certain conditions on a lifeless earth.

Even if the a priori probabilities of its happening the first time are virtually zero, Jacques Monod holds that it still might happen nonetheless.1 Furthermore, it has been demonstrated that the amino and nucleic acids which life requires could already have been made plentifully available by rather «impersonal» natural processes.

The apparent gap between nonliving and living has now been bridged by nucleic acids, a class of polymeric organic molecules composed of a succession of small units (nucleotides) of four sorts, the order of which determines an indefinitely large number of different specificities.

They are the principal component, other than water, of all living forms, but the nucleic acids alone have the remarkable property of being capable of duplicating their patterns, whatever they may be, from small molecules in their medium.

I have followed Polanyi's contention that there are organizational principles operative in the universe which formatively influence the specific sequences of nucleic acids in DNA, and with Sheldrake I have postulated the existence of morphogenetic fields which canalize the processes of growth and development in organisms.

The four major classifications of biological molecules are proteins, carbohydrates, lipids (fats), and nucleic acids (but we won't be dealing with these today).

«It's difficult to make contrived samples behave like actual cell - free nucleic acids, so that's been quite a challenge,» says Kelli Bramlett, director of R&D in clinical sequencing and oncology at Thermo Fisher Scientific in Waltham, Massachusetts.

«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of nucleic acid that binds a specific sequence in the gene.»

Of the three methods, nucleic acid — based liquid biopsies appear to be taking an early lead.

He studies DNA and RNA quadruplexes, nucleic acid structures that were first visualized via confocal microscopy in fixed, dead cells.

The new methods allowed them to catch proteins in the act of binding to RNA, and also identify what part of the protein was in contact with the nucleic acid.

In the study, which was published in the journal Nucleic Acids Research, the biologists utilised so - called riboswitches, also called RNA switches, and RNA thermometers.

The spherical structure of the SNAs is the ideal architecture for delivering nucleic acids into cells for gene regulation, Mirkin said.

They combined spherical nucleic acids (SNAs, which are nanoscale globular forms of RNA) with a common commercial moisturizer to create a way to topically knock down a gene known to interfere with wound healing.

The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.