Sentences with phrase «nucleic acids at»

However the team from the Krebs Institute for Nucleic Acids at the University of Sheffield found that the key to preventing resistance to a common class of chemotherapy used to treat breast and colon cancer is to change the speed in which the cancer cells repair damage to their DNA that is introduced by chemotherapy.

Not exact matches

Out of the Gordon Conference on nucleic acids in the summer of 1973 came an open letter to Science; the establishment (in October 1974) by the National Institutes of Health of the Recombinant DNA Molecule Program Advisory Committee; and in February 1975 the now - famous international conference at the Asilomar Conference Center in California, where a reluctant decision was made by scientists to declare a temporary moratorium on certain kinds of DNA research.

«It's difficult to make contrived samples behave like actual cell - free nucleic acids, so that's been quite a challenge,» says Kelli Bramlett, director of R&D in clinical sequencing and oncology at Thermo Fisher Scientific in Waltham, Massachusetts.

So that has made us look again at the chemistry of replication and start to explore a wider range of nucleic acids.

You can't necessarily see the change happening in the adult, but you can see that if you change that nucleic acid base right there in that gene, at that particular point in embryonic development, that animal is darker.

DNA repair is a hugely important topic and these three were the first to describe the repair mechanisms,» Thomas Carell, who studies nucleic acid chemistry at Ludwig Maximilians University in Munich, told Science.

The scientists at the Institute for Research in Biomedicine (IRB Barcelona) describe the uses of the program in an article published in the journal Nucleic Acids Research, in which they explain that ChroGPS is the answer to a problem that has been dragging on for the last ten years.

«As long as there are sufficient nucleic acids preserved in the specimen, there is really no limit,» says Alison Devault, a researcher at McMaster University studying ancient cholera.

Attendees at the astrobiology meeting in Arizona showcased an assortment of high - tech devices for next - generation exploration, ranging from microfluidic «life analyzers» and integrated nucleic acid extractors for studying «Martian metagenomics» to exquisitely sensitive, miniaturized organic chemistry labs for spotting tantalizing carbon compounds and minerals at microscopic scales.

It also hints at why proteins were eventually preferred by evolution over nucleic acids as catalysts in biology: proteins offer much more ability to «tune» their «jiggling and wiggling» and their response to chemical reactions.

At the nucleic acid level, understanding the precise regulation of genes through analysis of gene expression data will be of utmost importance.

BioGene is at the forefront of innovative, UltraRapid Molecular Biology solutions for rapid detection of nucleic acids and this research has led to a very exciting platform technology, and one that we are looking to develop further.»

«Recovering nucleic acids from ancient viruses is extremely difficult and plagued by contamination,» notes Angelique Corthals, a forensic anthropologist at the City University of New York in New York City, who was not involved in the study.

This realm of research is called epigenetics, and at the heart of it is chromatin — the nucleic acids and proteins that package DNA to fit inside cells.

Researchers at Stockholm University and Science for Life Laboratory have developed a new computer algorithm for analysing gene function called BinoX, which was e-published in Nucleic Acids Research on September 22 (Ogris et al., 2016a).

Life on Earth originated in an intimate partnership between the nucleic acids (genetic instructions for all organisms) and small proteins called peptides, according to two new papers from biochemists and biologists at the University of North Carolina at Chapel Hill and the University of Auckland.

The new research, published in the journal Nucleic Acid Research, describes how RNase E can cut at many sites internal to messages to prevent them being re-read.

With his wife, Margaret, Clark then moved to Boston, where he had secured a 3 - year postdoc with Jack Buchanan, a biochemist at the nearby Massachusetts Institute of Technology (MIT) who was investigating the synthesis of nucleic - acid building blocks called purines and of proteins.

So that made us look again at the chemistry of replication and start to explore a wider range of nucleic acids.

The result was several series of nucleic acid duplexes that ranged from having all RNA nucleotides to none at all.

The new work, like the 199 day finding, looked at nucleic acids and thus does not conclusively prove that the virus in semen can spread disease for 284 days.

For each sample type, a standard curve for the TMAdV PCR assay was calculated from 3 PCR replicates at each dilution of nucleic acid extracted from the spiked matrix (data not shown).

Leon A. Heppel, who carried out pioneering work in the areas of physiology and nucleic acid biochemistry, passed away on April 9 at the age of 97 in Ithaca, N.Y.

In the 11 years before joining the CNAG he worked at the Centre National de Génotypage of the Commissariat à l'Energie Atomique in Evry, France, first as Head of Technology Development and later as Associate Director under Prof. Mark Lathrop.His research interests are high - throughput nucleic acid analysis, sequencing, SNP genotyping, genomics, genetics, nucleic acid and protein analysis methods (molecular biological techniques and chemical modification), implementation of methods, automation and analysis.

Reverse transfection — the method whereby nucleic acids are localized on a substrate prior to addition of cells — was first developed in 2001 at Whitehead Institute for Biomedical Research by Junald Ziauddin and David M. Sabatini.

The insights we expect to gain from this study of mitochondria dysfunction and microRNAs, and what they tell us about how some RPE cells become diseased while neighboring cells are either resistant or susceptible to disease, hold promise of becoming the basis for entirely new therapies for individuals suffering from AMD, built upon nucleic acid - based treatments aimed at rejuvenating RPE cell mitochondria.

Roger Williams, Burke's postdoctoral advisor in the division of protein and nucleic acid chemistry at the Medical Research Council Laboratory of Molecular Biology, called Burke «simply one of the best postdoctoral researchers with whom I have worked in the 25 years that I have been a group leader in the Laboratory of Molecular Biology in Cambridge, UK.

The location and packing density of nucleic acids may control which genetic instructions are accessible and active at any given time.

FINDINGS The researchers identified 32 known imprinted genes, but no new ones, implying that the list of imprinted genes in the mouse — at least in embryonic fibroblasts — is nearly complete, says Morison, who was not involved in the study (Nucleic Acids Res, 42:1772 - 83, 2014).

The tissue samples were immediately weighed, snap - frozen in liquid nitrogen, and stored at − 80 °C before nucleic acid extraction.

Dean Madden and John Schollar from the National Centre for Biotechnology Education at the University of Reading, UK, suggest a recipe for a cocktail containing deoxyribose nucleic acid (DNA.)

We reasoned that contamination from XMRV - infected LNCaP cells was more likely given that the laboratory at the Cleveland Clinic performing the nucleic acid extractions in 2004 was simultaneously working with LNCaP and had only worked with 22Rv1 more than 2 years prior.

Probes and cell nucleic acids on each slide were co-denatured for 3 min at 73 °C and immediately hybridized for 16 — 24 hours at 37 °C on a ThermoBrite (Abbott Molecular, Inc.).

But it's a loose match at best — not every base pair matches its complementary nucleic acid.