Nucleic acid analysis skills required.
In the 11 years before joining the CNAG he worked at the Centre National de Génotypage of the Commissariat à l'Energie Atomique in Evry, France, first as Head of Technology Development and later as Associate Director under Prof. Mark Lathrop.His research interests are high - throughput
nucleic acid analysis, sequencing, SNP genotyping, genomics, genetics, nucleic acid and protein analysis methods (molecular biological techniques and chemical modification), implementation of methods, automation and analysis.
These improvements push the boundaries of nucleic - acid detection and fragment sizing, affecting applications such as single - cell
nucleic acid analysis, PCR - free preparation of NGS library preparation, bacterial artificial chromosome clone sizing, and exosome analysis.
Not exact matches
Says Roberts: «He quickly figured out that if Illumina was successful, it would need more than the world's supply of oligonucleotides» — the short snippets of
nucleic acid that are designed to pair up with specific genetic sequences, and which are critical for DNA or RNA
analysis.
Using a combination of old - fashioned clinical observation and modern biochemical
analysis, he has shown that a person's appetite and their eating behavior can be linked to specific genes — and that even a tiny defect such as the absence of a single
nucleic acid in a sequence of DNA can lead to runaway weight gain.
The article in the journal Molecular Therapy —
Nucleic Acids titled «As Technologies for Nucleotide Therapeutics Mature, Products Emerge» describes the
analysis of more than 60,000 research publications related to oligonucleotide therapies.
At the
nucleic acid level, understanding the precise regulation of genes through
analysis of gene expression data will be of utmost importance.
BioGene Limited are based near Cambridge and provide a «solution - based» portfolio of products, services and support — to encompass the key application areas of molecular biology to include
Nucleic Acid Purification, Target Amplification and Post-Amplification
Analyses.
The isolated intact exosomes and other EVs can be used in electron microscope
analysis; nanoparticle tracking
analysis; administration of EVs; and
analysis of proteins, lipids, or
nucleic acids.
Extracted
nucleic acid was amplified using a random PCR method to generate cDNA libraries for Virochip and deep sequencing
analyses as previously described [18], [21].
a toolkit to perform Normal Mode
Analysis (NMA) in internal coordinates (IC) on both protein and
nucleic acid atomic structures.
He'd like a way to perform single - cell
analysis using microarrays, instead of full sequencing, but chip - based bisulfite methods require more
nucleic acid — about a microgram — than one cell can provide.
Large - scale and effective studies of biological molecules with a different structural basis such as proteins,
nucleic acids, carbohydrates, lipids and numerous metabolites (including e.g. fatty
acids, amino
acids, purines, pyrimidines or steroids) is currently highly attractive because of the availability of modern instruments and tools for both separation and
analysis (2 - D chromatographs, capillary electrophoresis systems, microfluidics, mass spectrometers, powerful NMR spectrometers, DNA / RNA arrays and others).
Keywords: Gene expression, High performance liquid chromatography, Mass spectrometry, Microarray
Analysis,
Nucleic acid hybridization, Polymerase chain reaction - quantitative, Purification
Genetic and genomic
analysis of
nucleic acids from environmental samples has helped transform our perception of the subsurface as a major reservoir of microbial novelty.
Here we present fCCAC, an application of functional canonical correlation
analysis to assess covariance of
nucleic acid sequencing datasets such as chromatin immunoprecipitation followed by deep sequencing (ChIP - seq).
For high - throughput screening using fragment
analysis, RNA was isolated using a MagnaPure LC system with a MagnaPure LC total
nucleic acid isolation kit (Roche) according to instructions from the manufacturer.
Basically, PCR is a technique that takes a few strands of
nucleic acid, generally DNA (sometimes RNA), and multiplies them until there are enough for the
analysis.