Sentences with phrase «nucleotide polymorphisms used»

Eight Single Nucleotide Polymorphisms Used as an Instrument for Increased Waist - To - Hip Ratio Adjusted for Body Mass Index in Women but not in Men

Not exact matches

The lab has also shifted from testing genetic markers known as short tandem repeats (STRs), which are standard in paternity testing, to recording single letter variants in the genetic code known as single nucleotide polymorphisms, or SNPs, which are rarely used for this purpose.

Single nucleotide polymorphisms (SNPs, used as genetic markers in DNA profiling) can produce single amino acid polymorphisms (SAPs) in the amino acids that make up protein.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

Using these data, we built a genetic model that includes 150 single - nucleotide polymorphisms (SNPs) and found that it could predict EL with 77 % accuracy in an independent set of centenarians and controls.

In their study (1), Sebastiani et al. used a number of different genotyping platforms and neglected to perform data quality - control steps, which resulted in their reporting several false - positive single - nucleotide polymorphism (SNP) associations.

The short note, by Editor - in - Chief Bruce Alberts, acknowledged that the study's authors «used a number of different genotyping platforms and neglected to perform data - quality control steps, which resulted in their reporting several false - positive single - nucleotide polymorphism (SNP) associations.»

Objective To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and / or NSAIDs and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

The unit provides genetic testing services using a combination of both microsatellite and single nucleotide polymorphism (SNP) panels for characterizing and selecting breeders in a wide variety of inbred mouse strains subsequently used for the generation of congenic animals.

An algorithm which uses bootstrapping to rank single nucleotide polymorphisms (SNPs) for disease association.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

The sequence data easily can be used to identify single nucleotide deletion, insertion, polymorphism and translocation and copy a number of changes on the DNA level.

In this project, I applied NASP for single nucleotide polymorphism (SNP) identification and characterization, and used FigTree and PHYLOBar for phylogenetic analysis and visualization.The NASP method differs from other published SNP pipelines in terms of supported short - read aligners and SNP callers, the ability to call both monomorphic and polymorphic sites, and the ability to integrate the results from multiple SNP callers and identify the consensus set of SNPs that define the population structure.

To this end, we determined the susceptibility of 38 NAPCR1 isolates to ten antibiotics from seven classes using E-tests or macrodilution tests and examined 31 NAPCR1 whole - genome sequences to identify single nucleotide polymorphisms and genes that could explain the observed resistance phenotypes.

Methods: Here we genotype 276 single nucleotide polymorphisms (SNPs) in 5199 P. falciparum isolates from two Kenyan sites and one Gambian site to determine the spatio - temporal extent of parasite mixing, and use Principal Component Analysis (PCA) and linear regression to examine the relationship between genetic relatedness and relatedness in space and time for parasite pairs.

According to VIN, commercial genetic testing uses small mutations in the canine DNA (single - nucleotide polymorphisms, or «snips»), to determine a breed (VIN).

Scientists used gene chips containing feline single nucleotide polymorphisms (SNPs)-- variations from the common feline DNA sequence that can help track down genes responsible for genetic diseases — to conduct their investigations.

Whole genome association analysis studies that utilize single nucleotide polymorphism (SNP) markers have been used to identify the molecular causes of various traits and conditions including genetic mutations within breeds that cause coat color variations [15], hairlessness [25] and defects in spinal development [26].

The moderating effects of three single nucleotide polymorphisms (SNPs)(rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task.