Number of trials using common combo strategies: Anti-CTLA-4 agents (251); Chemotherapies (170); Radiotherapies (64); Anti-VEGFA agents (43); Chemoradiotherapy combos (42).
Not exact matches
Besides randomized controlled clinical
trials, there are a
number of ways researchers can study how a particular cancer treatment is playing out in the real world: there are retrospective studies, observational studies, and even prospective research done
using patient registries.
Kirra Cheers, a photographer from Brooklyn, recently set out to document her
trials and tribulations
using Tinder, a wildly popular app that allows users to approve or deny potential mates based on a small
number of pictures and a short bio.
In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month
of age.280 A more recent systematic review found that the highest level
of evidence (ie, from clinical
trials) does not support an adverse relationship between pacifier
use and breastfeeding duration or exclusivity.281 The association between shortened duration
of breastfeeding and pacifier
use in observational studies likely reflects a
number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled
trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.
Have
trialed many, many brands
of all price ranges and different systems - currently with a 19 lb baby these are
number one: Soft fleecy lining wicks moisture away quickly, soft elastic legs fit comfortably with minimal marking on baby - Pricey but we have since purchased more as they have become our «go to» for both night and day -
used with single or double bamboo insert for another company.
Peers from the across the political spectrum (but notably many Liberal Democrats) voted for a
number of measures which guarded against the plans, including giving judges, not Ministers, the say over the
use of the secret
trials.
There have been a
number of human clinical
trials using an alternative gene - editing technique, including one led by June, that have helped patients combat HIV.
«If we find that lymphoscintigrams
using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization
of sentinel nodes, we would like to see a randomised clinical
trial involving large
numbers of patients,» says Prof de Bree.
A statin drug commonly
used to lower cholesterol is not effective in reducing the
number and severity
of flare ups from chronic obstructive pulmonary disease (COPD), according to the results
of a large multicenter clinical
trial designed and directed by Gerard J. Criner, MD, Director
of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..
Young also hopes the results, which should be compiled by the end
of the year, will provide enough preliminary evidence to help raise funds for a larger
trial testing the
use of social media to combat abuse
of a broader
number of substances.
Following a
number of successful clinical
trials the
use of use of baclofen increased massively and sales
of the drug have soared in some countries.
They also summarise the outcome
of clinical
trials that have investigated the
use of mesenchymal stem cells in the treatment
of a
number of inflammatory, degenerative and immune - mediated diseases
of cats.
A
number of fundamental problems stand in the way
of practical implementation
of such systems: insufficient rechargeability; numerous side reactions that limit the stability; and, in
trials using lithium, clogging
of the porous electrode by lithium peroxide.
A systematic review
of published studies on the
use of medical cannabis in children and adolescents finds a notable lack
of studies and a minimal
number of the randomized, controlled
trials needed to confirm the effectiveness
of a treatment.
In an editorial accompanying the published article in Circulation, experts from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis
of large
numbers of patients, the results
of METOCARD - CNIC
trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when
used in conjunction with primary PCI nurtures great hope in clinical benefit.»
The next step is for grouse managers and conservationists to
use the results
of the model to agree on an acceptable
number of harriers and then test the idea in a field
trial.
Although these platforms can be
used successfully for small - scale expansion
of hMSCs, other platforms will be required to generate the quantity
of cells required to support the increasing
number of clinical
trials utilizing hMSCs and the subsequent large - scale production.
take a lead in developing the next generation
of cancer cell lines and
use cell lines to systematically explore in vitro sensitivity to large
numbers of anticancer drugs and drug combinations in order to inform choice
of cancer types for early drug
trials.
«Lithium, long
used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a
number of small clinical
trials.
Based on positive results produced from a
number of scientific clinical
trials, coronary artery disease therapy
using adult stem cells is a promising new method
of treatment for coronary artery disease patients.
Although the
trial was relatively small in terms
of the
number of patients, it was unusually rigorous in the methods
used to analyze heart metabolism, according to Gropler.
In a substudy, review outcomes were also compared across different types
of clinical research, based in large part on the designations and definitions derived from a
number of sources, including a report by Nathan, 14 the Institute
of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association
of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1
of the following: (1) patient - oriented studies
of mechanisms
of human disease (bench to bedside); (2) clinical
trials and other clinical interventions; (3) patient - oriented research focusing on development
of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies
of normal human behavior); (6) health services research; and (7)
use of deidentified human tissue.
Finally, there are a
number of rating scales that have been
used by physicians to score signs
of HD, and these were measured as well, allowing the TRACK - HD scientists to compare their information to older
trials.
A
number of their top quality products are also certified for
use in investigative clinical
trials by the Medicines and Healthcare Products Regulatory Agency.
The National Cancer Institute and the National Center for Complementary and Integrative Health (NCCIH) are sponsoring a
number of clinical
trials (research studies) at medical centers to test CAM therapies for
use in cancer.
There is no doubt that there are many websites for meeting black singles and many
of those offer free
trials which means that you are going to get a chance to
use the free period in order to see whether or not you are going to like the websites and if you are satisfied with the
number of the members, design and all the things that matter when it comes to black dating.
This site is catered to comparatively new sugar daddies and sugar babies.Now the site is amongst the most popular websites in the sugar daddy dating domain and boasts
of a large
number of active users.SugarDaddyToday
uses 100 % FREE membership for seven days to attract users, but you'll need to pay $ 5 monthly after your free
trial is over.
Just a heads up that as the new year sets in, some chatline companies might be resetting their database
of phone
numbers that have
used up their free
trials.
To start
using MetroVibe, call one
of the many free
trial numbers available.
Starting with finding square roots
of numbers using trial and improvement, structured to lead students to more difficult questions.
Gerry Buckley, CEO
of NIS explained: «We had done
trials with a
number of different video conferencing options, comparing factors such as image and sound quality, ease
of use and price.
She leads a
number of studies that evaluate education programs
using rigorous econometric methods, including randomized control
trials, propensity score matching methods, and other quasi-experimental evaluation designs.
When given a two - digit
number, Johnny Student will model the
number using place value rods and blocks, with 90 percent accuracy in four out
of five
trials administered over a one - week period as measured by teacher - charted data and work samples.
Some email marketing services offer free
use of their service for a
trial period or free forever up to a certain
number of subscribers or messages.
It was
trialed on a
number of vessels to get feedback on how it could be integrated,
using existing systems and the limitations
of satellite internet.
Playster in hand with their questionable affiliates make many bogus websites,
numbering in the many thousands, that abuse thousands
of authors copyright rights, in order to profit in bad faith and deceive people in signing up for free
trials using the bait
of PDF...
When I heard about the 3 month free
trial at Scribd, and looked at their collection (they have a
number of niche publishers that the public library is never going to stock in bulk), I only had to make sure I had the correct kind
of device to
use it properly before signing up.
If you contact one
of the three companies individually (or
use any other credit monitoring service), they will likely charge you a fee and require a credit card
number for a free
trial in order to gain access to your report history.
Often times attornies will recommend that you take a settlement to avoid a costly
trial, often that force you to accept a series
of payments over a
number of years, which might be if you don't have any immediate need to make
use of that money, but if you have major health bills or any other immediate need for the money that you've received from a lawsuit, a payment over many years simply won't do much for you.
The double - blind, placebo - controlled studies
used the state -
of - the - art force - plate analysis, a statistically significant
number of dogs participated in the
trial and showed significant improvement at a 95 % confidence level.
While the new update (as
of 2014) doesn't increase the
number of animals required (just 6 must complete the 6 - month adult
trial), it does require better documentation
of control groups and test observations, improves requirements for puppy food
trials, and implements tighter controls on statistics
used to interpret results.
Hyatt
used to have a pretty generous Diamond
Trial that provided status up front but still required a certain
number of stays in order to keep it — typically 12 nights in 60 days.
You will be pleased to know that I plan to continue to develop my Japan Travel Planning Facebook Group — I have more articles I want to write about Japan, I am also planning to
trial some options to increase the
number of members
of the group, potentially through advertising as well as better utilisation
of other social media channels, as not everyone wants to
use Facebook.
Drugs are tested by the people who manufacture them, in poorly designed
trials, on hopelessly small
numbers of weird, unrepresentative patients, and analysed
using techniques which are flawed by design, in such a way that they exaggerate the benefits
of treatments.
The project will
trial a
number of different
use cases for energy storage, including self - consumption
of onsite generated PV power, grid stabilisation and arbitrage.
For each run, a random -
number generator was
used to select the stations with a 1 out
of 10 probability for each random -
number «
trial».
There are already a
number of blogs dedicated to the
trial, none I could find that were much
use, and coverage on the Globe and Mail.
«The case is one
of a rising
number nationally in which jurors have
used iPhones, BlackBerrys and home computers to gather and send information about cases, undermining judges and jury
trials,» writes Courier - Journal reporter Andrew Wolfson.
For many reasons, including tort reform and a rise in the
use of alternative dispute resolution, the
number of trials has greatly declined.
Court costs include certain costs
of trying the case such as the jurors» daily fees, the costs
of subpoenaing witnesses to testify and the expense
of depositions which may be
used at
trial, as well as a limited
number of other items.