Sentences with phrase «numerous subsequent studies»

Numerous subsequent studies have confirmed that a calorie restriction of 30 to 60 percent of ad libitum intake increases the life span by similar amounts in a range of organisms including yeast, roundworms and rodents, while simultaneously decreasing or delaying the occurrence of age related diseases such as numerous cancers (including lymphomas, breast and prostate cancers), hypertension, stroke, diabetes, nephropathy, autoimmune disorders and other risks factors for cardiovascular disease (3,4).

Not exact matches

DGKζ, a lipid kinase, phosphorylates the second messenger DAG, terminating DAG - mediated activation of RasGRP1 and PKC - θ, whereas Cbl - b, an E3 ubiquitin ligase, facilitates ubiquitination and subsequent degradation of the p85 subunit of PI (3) K. Previous studies have evaluated numerous aspects of T cell biology in the two models (16 — 18, 25, 38), but the signaling and functional effects of DKGζ deficiency and Cbl - b deficiency in T cells had not been directly compared.

There have been numerous studies carried out what is the prime driving force for people to make donations, or give freely when an appeal is launched on national Television and what governs the subsequent impulse to react in that specific way.

As a result, one or two good studies are often referenced over and over again in subsequent studies so while it looks like there are numerous studies that confirm a hypothesis, much of the research still relies on one or two pieces of research.

Although this is the first prospective longitudinal study to investigate this mediational hypothesis in a systematic manner, our findings are consistent with previous findings indicating that disruption of interpersonal relationships is a predominant risk factor for suicide10, 13,49 and that interpersonal conflict or separation during adulthood partially mediated an association between neglectful overprotective parenting and subsequent suicide attempts.23 The present findings are also consistent with research indicating that stressful life events mediated the association between childhood adversities and suicidal behavior during adolescence or early adulthood, 8 that suicide is multidetermined, 2 and that youths who experience numerous adversities during childhood and adolescence are at a particularly elevated risk for suicide.18, 22,49