Sentences with phrase «oar cell»
In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.
https://www.firstthings.com/ Not exact matches
OAR proponents claim that when the altered donor - cell nucleus with its activated nanog gene is transferred to the enucleated oocyte (egg cell), the presence of nanog will immediately convert the enucleated egg cell to a pluripotent cell, without ever forming a zygote.
If this ideal situation proved to be consistently the case in animal experiments, then there would be near - absolute certainty that the cells produced by ANT - OAR are merely cells and not embryos.
As I stated in my original article, prior to conducting experiments with human cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees with reasonable certainty that an embryo is not generated.
Condic and her colleagues propose a procedure, called «oocyte - assisted reprogramming» (OAR), which they claim will produce a pluripotent cell without first producing a totipotent zygote, the single - cell embryo.
The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.
No embryo has been generated, no organism «cloned» if ANT - OAR succeeds in its goal of producing nothing other than pluripotent stem cells.
OAR produces a crippled embryo» one whose cells can divide and differentiate to a certain stage in embryonic development and no further.
Should the ANT - OAR proposal work, the alterations made to the adult nucleus will ensure that the cell produced by ANT - OAR enters immediately into a restricted, pluripotent state, without ever generating a totipotent embryo.
The ANT - OAR proposal represent a scientifically and morally sound means of obtaining human pluripotent stem cells that does not compromise either the science or the deeply held moral convictions of those who oppose the destructive use of human embryos for research» which is a creative approach that can be embraced by both the anything - goes camp and the nothing - goes.
Such a single - step conversion of an adult cell into an embryonic stem cell entirely avoids the question of whether an embryo has been created, since the cell produced by ANT - OAR never exhibits any of the properties of a single - cell embryo.
The cell produced by ANT - OAR would have all of the positive properties of a pluripotent stem cell» as well as all of the restrictions in developmental potency such cells normally exhibit.