The facility maintains
a small molecule library of ~ 100,000 drug - like small molecules for high - throughput screening and provides access to liquid handling robotics and a multilabel plate reader.
The identification of disease signatures will enable screens of
small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.
Once the Vanderbilt
small molecule library has been screened for potential modulators of the Y4 receptor, I will use the results to design efficient and accurate descriptors that can be used with artificial neural networks to predict activity at the Y4 receptor based on a small molecule's structural properties.
Encoding method for OBOC
small molecule libraries using a biphasic approach for ladder - synthesis of coding tags.
Phenotypic screening of
small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.
The investigations are frequently combined with large scale perturbation methods, including gene - based (RNAi, miss - expression of wild type and mutant genes) and chemical approaches using
small molecule libraries.
Not exact matches
The technology is allowing basic scientists and
small companies to generate impressive
libraries of
molecules, on a scale once reserved for big pharma, and select from them the most useful compounds.
Still eager to make an MIS - like contraceptive for all women that is cheap and easy to use, perhaps as a pill, the researchers are searching
libraries of
small molecules to find one that mimics the action of MIS.
In this study, the researchers screened a
library of 200,000
small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.
Scientists for decades have applied similar «phenotypic selection» methods to
libraries of standard
small -
molecule compounds.
In one case, the researchers screened a
small -
molecule compound
library and identified compounds that bind tightly to NUCB1, an otherwise little - known protein that showed strong interactions with the arachidonoyl probes.
They identified AM404 as a potential antiviral agent by screening the National Institutes of Health Clinical Collection, a
library of
small molecules that have been used clinically in humans, using a high - throughput screening system.
Nikolas Jorstad and Matt Wilken, graduate students in Reh's lab, screened a
library of
small molecules to find one that could reopen access to the genetic code in the adult mouse.
To test DDX3's druggability, the team chose to design its own
small molecule rather than screen
libraries of
molecules already created.
The process of drug discovery has been dominated in recent years by the screening of large
libraries of structurally diverse
small molecules for effects on target proteins associated with disease.
Such projects involve developing and optimizing assays for automation, screening a large compound
library, and characterizing each
small -
molecule probe.
The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the
library of
small molecules for biologically active compounds in a variety of readout systems.
In another experiment, a more direct test of druggability, the researchers used a
library of
small molecules — broadly representing potential drug
molecules — to see which could compete with the probe in binding covalently to reactive lysines on human proteins.
Our current works have focused on screening the chemical
libraries to identify and further characterize
small molecules that can control stem cell fate in various systems.
UniChem supports the integration of high - throughput screening data on
small molecules with chemical
libraries and chemical resources for drug discovery and optimization.
The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active
small organic
molecules through screening of compound
libraries with the help of robust test systems and advanced instrumentation.
The emerging field of DNA - encoded chemical
library allows us to perform selection of
small molecule compounds.
With Jan Stichel at Annette Beck - Sickinger's lab, Leipzig University, Germany and David Weaver, head of the high - throughput screening facilities at Vanderbilt University, I will be screening Vanderbilt's
library of
small molecules for potential allosteric modulators of the human Y4 receptor.
Another key contribution made to the field is Schreiber's formal planning of diversity - oriented synthesis (DOS), which involves the creation of diverse
libraries of
small molecules for biological screening.
Using this information, we will then take advantage of recent advances in the quantification of assembly to screen candidate
small -
molecule libraries for enhanced activity in assembly acceleration, inhibition, and misdirection.
Then the wells were exposed to a
library of
small -
molecule compounds.
The team screened a
small molecule compound
library and identify a drug, which they call CLP257.