Sentences with phrase «orf expression»
The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.
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Experimental disruption of the ORF of an OR allele does not ablate its expression, instead another OR allele is co-expressed in the same cell [45], [46].