Sentences with phrase «olaparib on»
In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.
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Olaparib had no effect on tumors formed by breast cancer cells containing functional BRCA1 and BRCA2 genes.
Olaparib stopped prostate cancer growth, generating falls in prostate specific antigen (PSA) levels, falls in circulating tumour cell counts in the blood, and radiological responses on CT scans and MRI.
The results will lead on to the start of TOPARP - B, a second part of the trial in which only men with detectable DNA repair mutations will receive olaparib.
Based on these studies, the authors are designing a clinical trial to test whether DNA repair inhibitors, such as olaparib, are active against IDH1 - and IDH2 - mutant tumors.
The researchers found that women who took olaparib had a median of 8.4 months before their cancer came back, compared to 4.8 months for those on the placebo.
B, CT scans from patient 2 pre-olaparib, on treatment, and after resistance show a liver metastasis at 17 mm on February 8, 2016, decreased to 6 mm on June 16, 2016, after olaparib treatment began, and at 18 mm on September 13, 2016, respectively.