Sentences with phrase «olaparib targets»
Olaparib targets a molecule called PARP, and exploits weaknesses in cancer cells» ability to repair damage to their DNA.
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It could in future allow the PARP inhibitor olaparib to become a standard treatment for advanced prostate cancer, by targeting the drug at the men most likely to benefit, picking up early signs that it might not be working, and monitoring for the later development of resistance.
PARP (Poly ADP - Ribose Polymerase) inhibitors, such as olaparib, are targeted drugs that block an enzyme involved in many functions in the cell, including the repair of DNA damage.
Men with prostate cancer benefit from treatment with the pioneering drug olaparib — the first cancer drug to target inherited mutations — according to the results of a major trial.
«The findings of this study are exciting because they support the idea that combining these two targeted oral therapies results in significant activity in ovarian cancer, more so than olaparib alone,» said Joyce Liu, M.D., MPH, the lead investigator and medical oncologist at the Susan F. Smith Center for Women's Cancers at Dana - Farber Cancer Institute, Boston.
Tumours shrank in about 60 % of women who received the targeted drug, called olaparib (Lynparza), compared with 29 % of those who received chemotherapy.
Olaparib, taken in pill form, was designed to target cancers containing faulty BRCA1 and BRCA2 genes, while leaving healthy cells unharmed.