Study results for the first phase of
the osteosarcoma study at the Broad Institute supported by the IWF and the IW community have been published.
Update on IWF Heart Studies, IWF Rescue Grant Report, IWF Sponsored Speaker at IWADV 2013 (Osteosarcoma Vaccine Research), Second Gift to Continue Broad Institute IW
Osteosarcoma Study
Not exact matches
To address these questions, Dang, Altman, and Hsieh collaborated with Penn colleague, Aalim Weljie, PhD, research assistant professor of Pharmacology, using an
osteosarcoma cancer cell line to
study the interaction of MYC and metabolism in cancer cells.
Common forms of
osteosarcoma, driven by somatic versus inherited mutations, have also been closely linked by past
studies to p53 when mutations interfere with its function.
At the Children's Oncology Group, we work on the design and implementation of
studies regarding Ewing's sarcoma,
osteosarcoma, rhabdomyosarcoma, and other soft tissue sarcomas.
Here, we present the largest sequencing
study of
osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes.
Clinicians also conduct clinical research and three current, ongoing
studies include investigations into canine
osteosarcoma, the most common bone cancer in dogs; soft tissue sarcomas, the most common type of solid tumors in dogs; and feline fibrosarcoma, injection - site tumors in cats.
Purpose of
Study: Even when we can get local control of
osteosarcoma, most dogs will die of their disease within a year even if they have amputation and chemotherapy.
Purpose of
Study: Standard therapy for dogs diagnosed with
osteosarcoma has long been amputation of the affected limb followed by chemotherapy to prevent the spread of cancer.
IWF Launches Redesigned Website, Final report from the IW
Osteosarcoma Treatment
study, Epilepsy in the Irish Wolfhound — An Update, Abstract of
study on Interleukin - 12 as a cancer treatment, As the Summer Heats Up (tips for caring for dogs in the summer heat), Cardiac Health in Irish Wolfhounds
Studies have shown that dogs weighing 80 lbs or more are 60 times more likely to become affected with
osteosarcomas than smaller dogs, though the exact causes of this are not currently known.
We also are at the forefront of funding cancer
studies in dogs, including hemangiosarcoma, lymphoma and
osteosarcoma.
This
study evaluated the effectiveness of Fosamax (alendronate) as a palliative therapy for
osteosarcoma in Irish Wolfhounds.
A large
study * was conducted to answer a concern of some pet owners (and veterinarians)-- does fracture repair lead to
osteosarcoma?
Many factors are involved in deciding when (or whether) to spay or neuter dogs with a family history of cancer, especially: Transitional Cell Carcinoma, Hemangiosarcoma,
Osteosarcoma, Lymphosarcoma, or Prostatic Adenocarcinoma where the risk of cancer in some breeds in limited
studies appears to be higher if the dog is spayed or neutered.
A large
study * was conducted to answer a concern of some pet owners (and veterinarians)- does fracture repair lead to
osteosarcoma?
The impact of this
study was reduced by the fact that many breeds of dogs were included in the analysis and several other risk factors for
osteosarcoma such as patient height and weight were emphasized.
Risk factors for the development of
osteosarcoma in Rottweilers was
studied and reported by Cooley DM et al (Can Epid Bio Prev 2002).
Data collected from these dogs ultimately will serve as a control group for future
studies of
osteosarcoma therapies.
Dr. Fahey has published
studies on chemotherapy for lymphoma and
osteosarcoma.
«In order to be eligible for the
study, a dog with
osteosarcoma must have the primary tumor removed and undergo chemotherapy.»
«Elmslie's and Dow's
study, «Intravenous Gene Therapy for Canine Pulmonary Metastatic Cancer,» is currently being funded by a foundation grant and covers the
study for
osteosarcoma only.
Two metabolites of diflubenzuron, para-chloroaniline (PCA) and 4 - clorophenylurea (CPU), increased the incidence of hemangiosarcoma and
osteosarcoma in animal
studies.
The following chart summarizes the evidence associated with sterilization of dogs as far as predisposition to some common serious cancers according to the recent
studies: Type of Cancer Relative Risk Castrated Males Relative Risk Spayed Females
Osteosarcoma (bone cancer) 3.8 3.1 Bladder Cancer 2 - 4 2 - 4 Prostate Cancer 2.4 - 4.3 Splenic hemangiosarcoma 2.2 Mast Cell tumors 4.1
This
study is the most recent in a series of
osteosarcoma research projects funded by Morris Animal Foundation following the launch of an
osteosarcoma initiative by the Foundation in 2015 to fight metastatic disease in
osteosarcoma.
A pilot
study demonstrated this combination elicited a powerful, targeted immune response directed against
osteosarcoma cells in patients suffering from this type of cancer.
Starting this spring, we will be participating in a
study to evaluate the Canine
Osteosarcoma Vaccine, Live Listeria Vector (COV - LLV), a conditionally licensed product for dogs with osteosarcoma who have undergone amputation and c
Osteosarcoma Vaccine, Live Listeria Vector (COV - LLV), a conditionally licensed product for dogs with
osteosarcoma who have undergone amputation and c
osteosarcoma who have undergone amputation and chemotherapy.
Cisplatin and doxorubicin combination chemotherapy for the treatment of canine
osteosarcoma: a pilot
study.
Veterinary
studies report that dogs and cats with
osteosarcoma in the lower jaw have a better prognosis than those with cancer in the upper jaw, living approximately 9 months longer, with 1 - year survival rates ranging from 35 - to 71 %.
Morris Animal Foundation funds
studies researching gene therapies for canine cancer treatment and reports some success in treating
osteosarcoma, melanoma, soft tissue sarcomas, and lymphomas3.
Studies The Puppy Up Foundation helped fund with The Broad Institute: Title of
Study:
Osteosarcoma Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard Title of
Study: Mast Cell Tumors Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard
The Ohio State CTO is also continuing to partner with Nationwide Children's Hospital to
study bone cancer (
osteosarcoma) in both dogs and children with the hope of finding better treatments for this devastating disease.
Briefly, dogs were classified as having one of the 24 inherited disorders
studied (hemangiosarcoma, lymphoma, mast cell tumor,
osteosarcoma, aortic stenosis, dilated cardiomyopathy, hypertrophic cardiomyopathy, mitral valve dysplasia, patent ductus arteriosus, ventricular septal defect, hyperadrenocorticism, hypoadrenocorticism, hypothyroidism, elbow joint dysplasia, hip joint dysplasia, IVDD, patellar luxation, ruptured anterior cranial cruciate ligament, atopy or allergic dermatitis, GDV, cataracts in dogs 6 years or younger, epilepsy, lens luxation, and portosystemic liver shunt) only if the record included definitive confirmation of the condition by the veterinary medical teaching hospital staff or the referring veterinarian.
With regard to cancers, a
study on
osteosarcoma (OSA) in several breeds found a 2-fold increase in occurrence in neutered dogs relative to intact dogs [5].