The University of Florence team's 2011 statistical analysis of health outcomes for almost 1,700 male patients showed that those involved in stable extramarital relationships had about twice the cardiovascular disease as
other patients in the study, particularly if the man reported that his wife was still sexually interested in him.
Her symptoms got worse through the initial treatments — a common experience for
other patients in the study who she said had suppressed memories due to child abuse — before they got better.
Not exact matches
In our symptom
study, we obtained questionnaires from 7,847
patients about nasal, sinus and
other health symptoms.
Other studies, meanwhile, are examining tryp's potential efficacy as an antifungal agent; and as a prognostic indicator
in patients with brain cancer (as seen by increased uptake of the amino acid on a PET scan).
«While we are disappointed CheckMate - 026 did not meet its primary endpoint
in this broad
patient population, we remain committed to improving
patient outcomes through our comprehensive development program, including the ongoing Phase III CheckMate - 227
study exploring the potential of the combination of Opdivo plus [our
other cancer immunotherapy] Yervoy for PD - L1 positive
patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy
in PD - L1 negative
patients,» he added.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth
in revenues for its antiviral and
other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures
in European countries that may increase the amount of discount required on Gilead's products; an increase
in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift
in payer mix to more highly discounted payer segments and geographic regions and decreases
in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations
in ADAP purchases driven by federal and state grant cycles which may not mirror
patient demand and may cause fluctuations
in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or
other government action that could have the effect of lowering prices or reducing the number of insured
patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials
in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations
in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates
in the timelines currently anticipated; Gilead's ability to receive regulatory approvals
in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and
patients may not see advantages of these products over
other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical
studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta
in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes
in its stock price, corporate or
other market conditions; fluctuations
in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and
other risks identified from time to time
in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
A
study of the
patients visited regularly by the students (compared with a matched control group of
other patients) showed that the program had made a significant difference
in the general improvement and discharge rate of those visited.
They point to several
studies that show that there is a lack of cholesterol
in the brains of Alzheimer's
patients which is so vital for several functions, and also note that
other studies show this cholesterol deficiency
in dementia and Parkinson's disease as well.
Other studies have highlighted similar factors.19 20 21 Though attempts are being made to try to simulate home birth
in hospital — a midwife known to the
patient arranging delivery
in a non-clinical environment close to a specialist unit — some women will continue to choose home birth.
Citing a 2010
study finding that
patients who had at least two 2 rehabilitation visits for persistent dizziness after a concussion showed improvement
in their DHI scores (2), the
study said that on - field identification of dizziness could lead to earlier implementation of vestibular rehabiliation and
other modalities to treat dizziness, which may expedite recovery from concussion.
For example, the fact that 27 transfer
patients are listed as having a physician as their planned birth attendant is most likely due to errors
in birth - certificate completion; data are currently lacking to inform the degree of misclassification related to this and
others factors that affect the
study outcomes.
For the purposes of this economic evaluation, the forms were initially used
in a related
study funded by the National Institute of Health Research (NIHR) research for
patient benefit programme «assessing the impact of a new birth centre on choice and outcome of maternity care
in an inner city area,» which will be reported
in full elsewhere, comparing the costs of care
in a free standing midwifery unit with care
in an obstetric unit
in the same trust.16 The data collected included details of staffing levels, treatments, surgeries, diagnostic imaging tests, scans, drugs, and
other resource inputs associated with each stage of the pathway through intrapartum and after birth care.
A 2012
study in Brain, Behavior, and Immunity found that people who listened to a relaxation CD before and after surgery had less stress and a speedier recovery than
other patients.
Diagnosis was always confirmed by a physician, and breastfeeding information was always confirmed by
patients» mothers or
other older close relative (as previously mentioned, this was not a requirement
in pediatric
studies).
That
study showed how a similar model can be used to understand immune response
in patients with pancreatic cancer who survive longer than
others.
The
study adds to a growing body of research highlighting
other cognitive functions affected by aphasia, and indicates that the consequences of brain damage
in aphasia
patients may be more extensive than originally thought.
«
In making effective treatments easier for
patients, the hope is that we can reduce vision loss from glaucoma, and possibly
other diseases,» said
study author James D. Brandt, M.D., director of the UC Davis Medical Center Glaucoma Service.
While a clinician may find it difficult to parse whether a
patient's stilted conversational manner is rooted
in a lack of emotional connection or problems forming words, a brain scan
in Belger's
study made it clear, for example, that particular symptoms were more closely associated with disruption
in the brain's emotional processing areas, whereas
other symptoms were more closely associated with regions responsible for language and motor control.
Eighteen out of a projected 21
patients in Mithoefer's
study have already been treated, and
in many cases just two sessions dramatically diminished symptoms, which is remarkable because PTSD
in this group of subjects has been resistant to
other types of treatment.
Three Swedish hospitals and
other European clinics will cooperate during the
study which will target
patients with conditions resembling the one
in the case
study — that is, people who suffer from phantom pain and who have not responded to
other currently available treatments.
Other molecular information from
patients may reveal these so - called «hidden responders,» according to a Penn Medicine
study in Cell Reports this week.
Plastic surgeons and
other cosmetic professionals are familiar with the challenges posed by
patients with body dysmorphic disorder (BDD) seeking cosmetic procedures, reports a survey
study in the February issue of Plastic and Reconstructive Surgery ®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
By the early 1960s more than 1,000
studies on LSD and
other hallucinogens discussing the experiences of 40,000
patients had been published
in reputable medical journals.
Over a 30 - day period, seniors were 54 percent more likely to be readmitted to the hospital compared to
patients younger than 65 years, the
study reports, after accounting for differences
in other medical problems.
Now a University of Colorado Cancer Center
study published online ahead of print
in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or
other retinoids against some breast cancers: Because early clinical trials are often offered to
patients who have already tried
other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.
A single scan could diagnose the cause of foot pain better and with less radiation exposure to the
patient than
other methods, according to a
study in the March 2015 issue of The Journal of Nuclear Medicine.
In other studies, Fried actually saw associations forming — neurons that originally fired for celebrities (like Clint Eastwood) began to also fire for landmarks (like the Hollywood sign) after
patients saw pictures of the celebrity - landmark pairings.
Prof. Khatri and his team
studied the way the immune system responds to infection by looking at gene expression — which genes are active and which are not — and whether there are differences
in patients with malaria compared to
other infectious diseases.
«These
studies set the stage for newer approaches to lower the levels of these lipids
in patients with Gaucher disease and
others with precursors for myeloma.
«
In addition, we believe our
study design sets an important precedent for
other genetic diseases and will help inform discussions of how clinical research can coexist with deep concerns about genetic privacy and
patient autonomy.»
«Previous
studies examined
patients undergoing hip - fracture repair or
other urgent surgeries,
in which initial blood samples were collected after a significant stressor had already occurred,» she added.
The new drugs offer the hope of treatment to perhaps thousands of HIV
patients who have stopped responding to
other medications, says William Towner, medical director of the Kaiser Permanente HIV / AIDS research trials program and member of the
study team, which reported its findings online today
in The Lancet.
«Use of steps one to three triage criteria is not sufficient for identifying intracranial hemorrhage and death or neurosurgery for older
patients who suffer head trauma,» said the lead author of the
study, Daniel K. Nishijima, MD, MAS, of the University of California Davis School of Medicine
in Sacramento, Calif. «While we wait for
other studies to confirm our research, we strongly urge
patients to make their medication history available and known to their families and EMS providers, especially for situations that may arise where they can not speak for themselves.
Patients can save about $ 5,600 a year
in transportation and
other related expenses by staying
in their local hospital and avoiding transfer to a larger hospital elsewhere, the
study found.
Another problem is that modeling
studies, like this one, are inherently less powerful than
other kinds of medical research: randomized clinical trials, the gold standard
in medical research,
in which
patients are randomly assigned different treatments or no treatment; case - control
studies, which compare
patients who have a condition with those who do not; or cohort
studies, which determine the risk of contracting a disease by
studying a group of people with similar demographics.
The researchers also measured increased glutamate levels
in patients, which lines up with strong support for elevated glutamate reported
in other studies of first - episode psychosis.
Also, the VA
patient population was almost all male, and tended to have more chronic disease than the groups looked at
in other studies.
She and her colleagues will be publishing
other studies in the future where
patients» mental health is assessed over a period longer than four weeks.
Dr Grainger and his team are now working with
other groups at The University of Manchester to carry out further
studies on monocytes, particularly from
patients with inflammatory conditions, and are focused on identifying situations where this gut information system may have gone wrong such as
in inflammatory bowel diseases.
Although he is far from recovered, and although hopeful results
in one
patient don't mean the technique will work for
others, the
study adds to evidence that there might be a way to restore consciousness to some
patients — even years later.
Past
studies have suggested depression and
other neuropsychiatric symptoms may be predictors of AD's progression during its «preclinical» phase, during which time brain deposits of fibrillar amyloid and pathological tau accumulate
in a
patient's brain.
The first
study will examine these
patients over time,
in order to analyze
other important variables such as melanoma relapse, mortality, resistance to treatment, development of a second melanoma or
other cancers, and metastasis, including spread of the cancer to nearby lymph nodes (sentinel nodes).
The new findings, reported
in JAMA by a team from the University of Michigan Institute for Healthcare Policy and Innovation, confirm directly what
other studies have predicted or implied: That Medicaid expansion can help relieve hospitals» burden of caring for
patients who have little or no means to pay.
While the
studies addressed
in the paper focused on
patients taking opioids for non-cancer pain such as back pain and
other musculoskeletal ailments, similar
studies are now underway to examine the effect of naloxegol
in patients with chronic cancer - related pain.
«These
patients had a lower disease burden and were treated earlier
in the course of their disease, which distinguishes it from
other studies,» Gill said.
In their study, Fiona Havers, MD, MHS, and a team from the Centers for Disease Control and Prevention and several other institutions analyzed data for approximately 6,800 patients with acute respiratory illness who were seen at five outpatient care centers in Washington state, Wisconsin, Texas, Michigan, and Pennsylvani
In their
study, Fiona Havers, MD, MHS, and a team from the Centers for Disease Control and Prevention and several
other institutions analyzed data for approximately 6,800
patients with acute respiratory illness who were seen at five outpatient care centers
in Washington state, Wisconsin, Texas, Michigan, and Pennsylvani
in Washington state, Wisconsin, Texas, Michigan, and Pennsylvania.
Because there's evidence that the words we hear and the words we recall or imagine trigger similar brain processes, the
study, published online today
in PLoS Biology, suggests scientists may one day be able to tune
in to the words you're thinking — a potential boon for
patients who are unable to speak due to Lou Gehrig's disease or
other conditions.
At UC Berkeley, psychologists such as Allison Harvey, a co-author on the Journal of Neuroscience paper, have been garnering encouraging results
in studies that use sleep therapy on
patients with depression, bipolar disorder and
other mental illnesses.
«One criticism of the PARP drugs is they are not active
in patients who have developed resistance to
other therapies, but we found veliparib appears to be effective
in some platinum - resistant
patients with recurrent or persistent disease,» said Robert L. Coleman, MD, lead author of the
study and professor and vice chair of clinical research at the University of Texas MD Anderson Cancer Center, Houston.
In the future, scientists who study respiratory distress in insulin - dependent patients should seek out causes in the diaphragm independent of other skeletal muscles.&raqu
In the future, scientists who
study respiratory distress
in insulin - dependent patients should seek out causes in the diaphragm independent of other skeletal muscles.&raqu
in insulin - dependent
patients should seek out causes
in the diaphragm independent of other skeletal muscles.&raqu
in the diaphragm independent of
other skeletal muscles.»