Sentences with phrase «outcomes research trial»

In this study, researchers reviewed Spine Patient Outcomes Research Trial (SPORT) data for 105 patients, age 80 and older, and 1,130 patients younger than age 80 with lumbar stenosis alone or combined with degenerative spondylolisthesis.

An analysis of patients treated for lumbar stenosis and degenerative spondylolisthesis, who were enrolled in the Spine Patient Outcomes Research Trial (SPORT), was performed.

Researchers reviewed data from the Spine Patients Outcomes Research Trial (SPORT) of 1,235 patients diagnosed with DS or SS.

Not exact matches

Current research includes: co-leading organisational case studies in Birthplace in England, a national study of birth outcomes in home, midwife led, and obstetric led units; investigating the relationship between measures of safety climate and health care quality in A and E and intrapartum care; and conducting nested process evaluations of two trials of obesity in pregnancy behavioural interventions.

Research shows that families typically receive roughly half of the number of home visits expected.16, 17 For example, across three randomized controlled trials conducted of Nurse Family Partnership, average dosage of visits ranged from 45 to 62 percent.18 Research also shows that many, perhaps most, families enrolled in home visiting programs drop out before their eligibility ends.16, 19,20 Some home visiting studies have varied the dosage that families were offered and found that fewer home visits produced outcomes similar to higher levels of exposure.21

Other difficulties when conducting or evaluating research in this area include ensuring the equivalency of the control and experimental groups in randomized controlled trials (RCTs), 10 controlling for participant attrition (which may affect the validity of findings by reducing group equivalence) and missed visits (which may affect validity by reducing program intensity), 11 documenting that the program was fully and accurately implemented, and determining whether the program's theory of change logically connects program activities with intended outcomes.

The protective effects of breast feeding have been shown to be dose responsive16 17 18 and minimal breast feeding may not be protective.17 Researchers in lactation have advocated that research on promotion of breast feeding must target exclusive breast feeding, 19 and ours is one of the larger randomised controlled trials with this primary outcome.

Declan Devane is a co-author in one of the included trials in this review (Begley 2011) Jane Sandall was and is principal investigator for two studies evaluating models of midwife - led continuity of care (Sandall 2001), and co-investigator on the «Birthplace in England Research Programme», an integrated programme of research designed to compare outcomes of births for women planned at home, in different types of midwifery units, and in hospital units with obstetric sResearch Programme», an integrated programme of research designed to compare outcomes of births for women planned at home, in different types of midwifery units, and in hospital units with obstetric sresearch designed to compare outcomes of births for women planned at home, in different types of midwifery units, and in hospital units with obstetric services.

While randomized clinical trials are the gold standard of clinical research, such trials are not feasible for testing anesthesia technique in joint replacement surgeries, because the low incidence outcomes would require a huge number of patients.

Many physician scientists involved in clinical trials, epidemiology, and health services research are trained through master's programs completed either during or (more frequently) after medical school, with degrees in clinical epidemiology, biostatistics, public health, or health services and outcomes research.

Since randomized clinical trials — the gold - standard in research — don't accommodate patients» preferences, Zoellner and her research team used a study design called a «doubly randomized preference trial» to investigate whether giving patients a choice affects their treatment outcomes.

Called the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) and funded by the drug giant Novartis, the trial also found fewer cases of lung cancer in those on the treatment, rekindling basic research findings hinting that the same inflammatory pathway may initiate or spur the growth of such tumors.

And even when it is an option, researchers aren't always sure how to interpret data from trials that changed protocol midstream, says James Hoffman, medication outcomes and safety officer at the St. Jude Children's Research Hospital in Memphis, Tennessee.

Researchers, Dr Abi Rose and Dr Andy Jones, from the University's Addiction Research Team conducted a meta - analysis on all 12 clinical trials comparing baclofen with placebo on at least one of the described drinking outcomes, craving, anxiety, or depression.

The paper stresses that more research, especially randomized controlled trials with long - term follow - up, would be needed to reach a definite conclusion on the risk of TRT on cardiovascular outcomes.

«For the first time, we can predict the outcomes of modifying multiple genes involved in lignin biosynthesis, rather than working with a single gene at a time through trial and error, which is a tedious and time - consuming process,» says Jack Wang, assistant professor in NC State's College of Natural Resources and lead author of a paper about the research in Nature Communications.

«Since several BACE1 inhibitors are currently being evaluated in clinical phase 3 trials for the treatment of Alzheimer's disease, the identification of potential side effects will be of great importance to ensure a positive clinical outcome,» said Dr. Jochen Herms, a Professor of translational brain research at Ludwig - Maximilians - University Munich.

The research team conducted a randomized controlled trial in 14 health centers in New York City, and compared the birth outcomes of women who received CenteringPregnancy Plus group prenatal care to those who received traditional individual care.

This study was presented at the Featured Clinical Research Session I: Two - year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A Randomized Clinical Trial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health ReseTrial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Resetrial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Research.

«Given the continued high prevalence of multivitamin use in the US, it remains critical for us to understand its role on nutritional status and other long - term health outcomes through clinical trials such as PHS II and other new research initiatives.»

«FDA's approach to evaluation of recent hepatitis C drugs underscores the Agency's flexibility in considering innovative or alternative trial designs for drugs that have demonstrated highly promising outcomes in early phase development,» said Dr. Poonam Mishra, deputy director for Safety, Division of Antiviral Products / Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research and lead author of the Hepatology paper.

Research has suggested that standard therapies combined with drugs that inhibit PARP1 can kill cancer cells, but clinical trials testing PARP1 inhibitors in cancer patients have produced disappointing outcomes.

In 2009, the UK Medical Research Council and National Institute of Health Research, through the Efficacy and Mechanism Evaluation Programme, funded the Robotic vs Laparoscopic Resection for Rectal Cancer (ROLARR) trial to undertake an evaluation of the safety, efficacy, and short - and long - term outcomes of robotic - assisted vs conventional laparoscopic rectal cancer surgery.

While some are suggesting the failure of these BACE1 trials indicate that the amyloid plaque hypothesis for Alzheimer's disease may in fact be wrong, other recent research still suggests more targeted methods of inhibiting the enzyme could result in positive outcomes.

The MD Anderson Cancer Center Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy is home to an integrated clinical cancer research and clinical trials program that is aimed at implementing personalized cancer therapy and improving patient outcomes.

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The Liu laboratory applies biostatistics to several areas of research, including: basic cancer research and clinical trials of cancer immunotherapy; infectious diseases; behavioral and educational intervention research; and research on health care outcomes.

Principal emphasis is placed on clinical trials, but epidemiologic outcomes and other research may be supported as well.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanresearch, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanResearch, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanResearch and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanresearch focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanresearch; and (7) use of deidentified human tissue.

These Sister Journals bridge stem cell research and clinical trials to improve patient outcomes.

The ECOG - ACRIN Cancer Research Group contains an Imaging Core Laboratory to support a wide range of clinical trials associated with imaging that are developed across the Group's three scientific programs: Cancer Control and Outcomes, Therapeutic Studies, and Biomarker Sciences.

A systematic review of controlled yoga trials for adults with Type 2 diabetes (DM2) published in the Journal of Diabetes Research suggests that regular yoga practice may help to reduce a number of key risk factors and outcomes of the disease.

[5:01]-- Research paper; Glycemic variability — assessing glycemia differently and the implications for dietary management of diabetes by Jeannie Tay, Campbell Thompson, and Grant D. Brinkworth [6:47]-- Continuous glucose monitoring [8:29]-- Methods to diagnosis diabetes [9:29]-- Associated health issues with glucose variability [10:13]-- CSIRO study; Comparison of low - and high - carbohydrate diets for type 2 diabetes management: a randomized trial [10:43]-- The National Health and Medical Research Council (NHMRC)[14:34]-- The breakdown of macronutrients between the low carb and the high carb arm of the study [18:47]-- The outcomes of the study [22:52]-- How to approach reducing medication on a low carb diet [26:44]-- CSIRO announcement based on this study?

Whereas the few randomized controlled trials and observational clinical outcomes studies support the existence of a health benefit from fasting, substantial further research in humans is needed before the use of fasting as a health intervention can be recommended.

Because the oversubscribed charter schools in our sample admit students via random lotteries, comparing the outcomes of lottery winners (most of whom enrolled in a charter school) and lottery losers (most of whom did not) is akin to a randomized - control trial of the kind often used in medical research.

Of twelve randomized controlled trials — the gold standard of social science research — eleven found that school choice programs improve outcomes for some or all students while only one found no statistically significant difference and none found a negative impact.

We're thrilled that Magnolia's study — an independent, randomized control trial study, which is the gold standard for rigorous educational research — shows the positive and dramatic impact of our solutions on student learning outcomes.

Follow - up research continues today, studying the long - term outcomes for mothers and children in these three trials.

Of twelve randomized controlled trials — the gold standard of social - science research — eleven found that school - choice programs improve outcomes for some or all students, while only one found no statistically significant difference.

To receive this rating, models must provide considerable evidence indicating positive outcomes based on rigorous research, primarily randomized controlled trials (RCTs, also referred to as experiments) or solid quasi-experimental studies.

For his research, he conducted a Randomized Control Trial in Selective Schools in Perú to study the impact of cognitive and social skills of peers on educational outcomes.

The purpose of this SIG is to convene like - minded researchers and practitioners to share resources and ideas related to securing funding, executing research - to - practice - to policy trials of programming, and dissemination efforts towards the ends of improving outcomes for our most vulnerable student populations and the teachers who educate them.

Our board of directors recognized that there was a potential for creating significant value for shareholders by continuing operations, but on balance our board of directors concluded that the risks of a negative outcome, either due to failure of our research and development efforts to yield a successful outcome, or the failure to obtain necessary financing even with positive clinical trial data, and the resulting lower liquidation value in the future, outweighed the potential value to shareholders from continuing operations.

Clinical research is patient related research and includes patient - based research (including clinical trials), epidemiological studies, and outcomes and health management (implementation) research.

Clinical trials represent the cutting edge of medicine: research expertise meets new treatments and improved outcomes, including an improved understanding of the diseases, like cancer, that affect our animals.

Our firm uses cutting - edge settlement and trial techniques, exhaustive research and investigation, and thorough preparation to maximize the outcome of each client's case.

The ability to definitively label mock trial simulations as completely accurate in predicting trial outcomes would require extensive research and controlled experimentation.

Specifically, the research team evaluates factors which include, but are not limited to the following: firm profile and reputation, years of practice, education, training, trial experience, case outcomes, peer endorsements, client reviews, professional awards, professional memberships, leadership in legal organizations, community involvement, disciplinary status, and other noteworthy achievements.

For research projects on adverse civil trial outcomes in state courts and securities fraud class actions in federal courts, for instance, DecisionSet ® collaborated with Martin Asher of The Wharton School and Blakeley McShane of The Kellogg School of Management.

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