Sentences with phrase «ovarian cancer cells use»

Ovarian cancer cells use autophagy all of the time, but also lose several copies of autophagy genes resulting in a compromised capacity.

Not exact matches

The researchers then used a combination of existing United States Food and Drug Administration - approved drugs to target autophagy and found ovarian cancer cells to be highly sensitive to these drugs in several different mouse cancer models — even among cells resistant to standard chemotherapy.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cCancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancercancer.

In lab experiments, the research team used cell lines derived from 40 patient tumour samples to identify that CD151 contributes to the survival of cells of high - grade serous ovarian cancer origin.

Using the European Synchrotron Radiation Facility (ESRF), researchers analysed the effects of Organo - Osmium FY26 in ovarian cancer cells — detecting emissions of X-ray fluorescent light to track the activity of the compound inside the cells.

Top honors for both the 17 - to 18 - year - old category and the grand prize went to Shree Bose, who discovered that an energy protein of the cell, AMP kinase, plays a role in developing resistance to a drug commonly used to treat ovarian cancer.

Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells — which kill infected and cancerous cells — and demonstrates how they can be identified and selectively grown for use in personalized, cell - based immunotherapies.

First, we produced PARP1 - KO ovarian cancer cell lines using CRISPR / Cas9 gene editing to test the loss of PARP - 1 as a resistance mechanism to all clinically used PARP inhibitors.

Roswell Park Comprehensive Cancer Center researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cCancer Center researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancercancer.

David Lampi Hermanson, Ph.D., a 2014 - 2017 CRI postdoctoral fellow at the University of Minnesota, is investigating the use of natural killer (NK) cell - based immunotherapy for ovarian cancer.

Tanyi said he is eager to explore whether the dendritic - cell vaccine might also be used as a first - line treatment for women who are newly diagnosed with ovarian cancer.

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The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.

The team has tested its triple threat nanoparticles, containing drugs typically used to treat ovarian cancer (such as doxorubicin, cisplatin and camptothecin), against lab - grown ovarian cancer cells.

Olaparib is a PARP inhibitor, which is already used to treat certain ovarian cancer patients and prevents damaged cancer cells from repairing themselves after chemotherapy or radiotherapy.

The first step was to understand the biological signals that attract ovarian cancer cells to the omentum and use it for rapid growth.

Using state - of - the - art proteomics and associated computational methods, the Speicher laboratory is investigating protein changes associated with ovarian cancer, melanoma, cardiac injury resulting from breast cancer therapies, ectopic pregnancy, red cell diseases, and other clinical disorders.

February 10, 2015 New screening tool could speed development of ovarian cancer drugs University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.

University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.