Sentences with phrase «oxidase b»

Monoamine oxidase B, or MAOB, has been found to increase in older dogs.

The only two assays that yielded greater than 60 % inhibition at 10 μM J147 were then re-assayed to determine EC50 values: the dopamine transporter (EC50 = 0.649 μM) and monoamine oxidase B (EC50 = 1.88 μM) assays both carried out by MDS Pharma Services.

Fowler and her colleagues at Brookhaven National Laboratory found that cigarette smoke lowers levels of an enzyme called monoamine oxidase B, or MAO - B, that plays a role in the regulation of blood pressure and is critical to the functioning of multiple organs.

Not exact matches

To study the influence of monoamine oxidases (MAOs) during mammalian development, researchers from the laboratory of Boyang Jason Wu (Washington State University, USA) investigated a mouse model lacking both MAO isoforms (A and B).

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

The most common one of these is Catechol - O - methyltransferase (COMT) and Monoamine oxidase (MAO - A and MAO - B) which all speed up the activity of dopamine regulating enzymes (11, 12)

Is a selective monoamine oxidase - B inhibitor, which could enhance catecholamine neuronactivity and increases dopamine levels in dogs.

Type B monoamine oxidases are responsible for getting rid of dopamine when it is no longer needed.

Monoamine oxidases are enzymes we have in two areas: the brain (monoamine oxidase inhibitor - B) and in the liver / GI tract (monoamine oxidase inhibitor - A).

These may include accumulation of B - amyloid, declining neurotransmitter activities, or increased activity of monoamine oxidase - B, an enzyme that may catalyze the metabolism of dopamine.1

Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity