Sentences with phrase «parp1 hyperactivation»

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

She says that frequently exposing older people to foreign plasma may be unsafe, because hyperactivation of their immune systems could lead to autoimmune or inflammatory disease.

By binding not only CD28 but also its coligand B7 - 2 directly, superantigens potently enhance the B7 - 2 / CD28 interaction, inducing thereby T - cell hyperactivation.

Upon investigating the underlying molecular mechanism, they observed that mTORC1 hyperactivation enhances the level of the stress hormone FGF21 by depletion of the amino acid glutamine.

The analysis revealed that while performing working memory tasks, the young patients with concussion had initial activation that was greater than normal, known as hyperactivation, compared to young controls in the right precuneus and right inferior parietal gyrus of the brain, whereas the older patients had hypoactivation (less than normal) compared to older controls in the right precuneus and right inferior frontal gyrus.

In line with our in vitro data, Pkn1 — / — mice showed AKT hyperactivation, elevated NeuroD2 levels, and reduced expression of PF - PC synaptic markers during stages of PF maturation in vivo.

These unexpected findings may be related to the epileptic phenotype of many pedigrees of patients with early - onset familial AD and to the hyperactivation of neuronal networks in patients with sporadic AD and amyloid - positive nondemented subjects.

These findings are probably related to the epileptic phenotype of many pedigrees of patients with early - onset familial AD and to the hyperactivation of neuronal networks in patients with sporadic AD and amyloid - positive nondemented subjects.

Catalase abrogates ß - lapachone - induced PARP1 hyperactivation - directed programmed necrosis in NQO1 - positive breast cancers.

Brain functional correlates of working memory: reduced load - modulated activation and deactivation in aging without hyperactivation or functional reorganization.

ST2 contributes to T - cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice.

Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

Researchers generally attribute tissue thickening (and ensuing damage to small blood vessels) to hyperactivation of skin cells called fibroblasts.

In addition, many cancer cells express insulin receptors (IRs) and show hyperactivation of the IGF1R - IR pathway.

Stress, primarily through hyperactivation of the HPA axis, appears to contribute to the accumulation of fat tissue, and vice versa, obesity itself seems to constitute a chronic stressful state and may cause HPA axis dysfunction.

Hyperactivation of p53 during glucose oscillation might be due to the absence of consistent feedback inhibition during each glucose spike and might account for the worse outcome of this condition.»

Often, living in a pernicious environment leads to hyperactivation of our immune gut cells and what would normally not cause an immune response, now does.

In males, corticosterone levels were elevated only in response to the 40 % CR diet, whereas in females corticosterone levels were significantly elevated in response to all three energy - restriction diets, suggesting a relative hyperactivation in females of the adrenal stress response to reduced energy availability.

The functional consequences of these structural changes include more anxiety related to both hyperactivation of the amygdala and less top - down control as a result of PFC atrophy as well as impaired memory and mood control as a consequence of hippocampal reduction.

This hyperactivation results in threats detected in nearly every interpersonal transaction.

Furthermore, this hyperactivation intensifies negative emotional responses to these threats and results in excessive rumination about threats (Mikulincer et al. 2003).

This hyperactivation is initiated by the individual's confusion about the viability of seeking proximity when they need help from their attachment figures, and are impacted extensively by their internal working models.