Sentences with phrase «pi3k subcomplex»

Not only must the complex locate subordinate subcomplexes, but it must itself be a subcomplex of another, perhaps more pervasive, complex.

Experiments and mathematical models showed these chaperones are important to prevent a subcomplex known as the regulatory particle from combining with the core particle before the particle is fully formed.

The project focuses on the dynamics of transient microcompartments formed by the V - ATPase holoenzyme, V - ATPase subcomplexes and subunits together with the mentioned proteins, with the aim to understand the mechanisms leading to this unique type of physiologically relevant regulation.

For this purpose analyze, on the one hand, the interaction of the V - ATPase, its subcomplexes and subunits with the mentioned proteins biochemically and by cryo - electron microscopy.

Determination of the structure of the entire complex was possible only through this step - by - step approach, building on from smaller subcomplexes towards the entire assembly.

We show here that the S. cerevisiae Csm1 / Lrs4 monopolin subcomplex has a distinctive V - shaped structure, with two pairs of protein - protein interaction domains positioned approximately 10 nm apart.

Vps34 activity in autophagy is tightly controlled by assembling the autophagy specific class III PI3K subcomplex (Vps34 / p150 / BECN1 / ATG14)[66,67,71 - 74].