«We found that galeterone resulted in meaningful
PSA declines in patients with metastatic CRPC, and imaging showed that the disease was stable or had responded to the drug,» Prof Taplin will say.
Among patients who were resistant to enzalutamide, nine were evaluable; five out of nine (56 %) had
any PSA decline.
Among patients who were resistant to abiraterone, 37 were available for evaluation; 13 out of 37 (35 %) had
any PSA decline.
Not exact matches
PSA levels
declined by 30 % or more (
PSA30) in 50 out of 60 (83 %) patients, of whom 42 (70 %) went on to have
declines of 50 % or more (
PSA50).
«Results from our study support the argument that
declining PSA screening may result in delayed diagnosis, potentially leading to avoidable cancer deaths,» according to John M. Corman, MD, Virginia Mason, Seattle, WA.
The difference in
declines may reflect perceptions among physicians on the benefit of
PSA screening, conflicting guidelines (for example, the American Urological Association recommends joint decision making for men 55 to 69), and possibly patient demographics or expectations.
Declines in prostate - specific antigen (
PSA) testing differed among urologist and primary care physician visits in a study that compared testing before and after a 2011 recommendation from the U.S. Preventive Services Task Force against
PSA screening for all men, according to an article published online by JAMA Internal Medicine.
Results also showed 27.7 percent of patients in the ADT plus docetaxel arm had a
decline in prostate specific antigen (
PSA) to less than 0.2 ng / mL at 12 months compared with 16.8 percent for those taking ADT alone.
Since the advent of
PSA screening, the incidence of patients presenting with advanced prostate cancer has
declined remarkably and death rates from prostate cancer as reported in the National Cancer Database have
declined at the rate of 1 % per year since 1990.56 Other data indicate similar
declines in prostate cancer related mortality in the US.
Therefore, the decreases in testosterone observed in this study may relate to the acute stress attendant with impending surgery - a
decline in testosterone that then drives
PSA downward.»
PSA and Opel public relations
declined comment on the report, Reuters said.
It turns out that the positive predictive value of that test is rather meager, which is one reason, among others, why the popularity of
PSA testing has
declined in recent years.
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If your prostate has been removed, the term life insurance companies will typically
decline any applicant with a
PSA of 0.02 or higher.