Sentences with phrase «paneth cells engineered»

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

On an additional project with former MIT graduate student Eric Grovender, Ameer co-developed a cartridge filter that purifies blood, «based on protein and cell engineering,» for those suffering from chronic kidney failure.

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

A baby's leukemia was successfully treated in 2015 with CAR - T cells engineered with gene editors known as TALENs.

Nonetheless, for the researchers, «The success of our cell engineering experiments, which make it possible to produce nerve cells in a controlled and unlimited manner, and to transplant them, is a world first.

«This paper is a great example of how chemistry can help make step changes in biology,» says Matthew Dalby, a professor of cell engineering at the University of Glasgow and co-senior author on the study with Ulijn.

In tests on human brain cells engineered to make more normal prions than usual, Hooper found that the cells secreted far less amyloid beta peptide than they would ordinarily.

So we might just be able to deal with cell loss if we had a sufficiently sophisticated program of stem cell replenishment — using cells engineered to lack the one linchpin function for cancer, namely telomere elongation.

In a boon to stem cell research and regenerative medicine, scientists at Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston University have created a computer algorithm called CellNet as a «roadmap» for cell and tissue engineering, to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies.

CellNet and its application to stem cell engineering are described in two back - to - back papers in the August 14 issue of the journal Cell.

The scientists first compared mouse megakaryocyte cells created from embryonic stem cells engineered to lack p45 - Nfe2 with normal megakaryocytes.

Such materials can be patterned with live cells engineered to sense environmental chemicals and pollutants as well as changes in pH and temperature.

Lu provided the team with bacterial cells engineered to light up in response to a variety of chemical stimuli.

The team first tested the antibody in cultured cells engineered to express the Nav1.7 sodium channel.

Another possibility is attaching the contrast agent to immune cells engineered to attack a patient's tumor, allowing the cells to be tracked inside the body.

Dr. Sadelain's research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders.

On the flipside, they found mTORC1 activation defective in cells engineered to lack expression of SLC38A9.

Taking a chance with a shoestring budget compared to other researchers doing similar projects, he added stem - cell engineering to his research program.

BERKELEY, CA, and CORALVILLE, IA — February 23, 2016 — Caribou Biosciences, Inc., a developer of CRISPR technologies for precision cell engineering, and Integrated DNA Technologies, Inc. (IDT), a producer of custom synthetic oligonucleotide - based technologies for genomics applications, have entered into a non-exclusive license agreement under which Caribou has granted IDT worldwide rights to commercialize CRISPR - Cas9 reagents under Caribou's intellectual property.

He and his colleagues showed that nerve cells engineered to produce amyloid - beta were better able than other cells to stand up to the infectious Candida albicans, a fungus.

Caribou Biosciences, a developer of CRISPR - Cas9 technologies for precision cell engineering, today announced that co-founder Jennifer Doudna, Ph.D., has been named to TIME magazine's TIME 100 - TIME's annual list of the 100 most influential people in the world.

BERKELEY, CA — March 24, 2016 — Caribou Biosciences, Inc., a developer of CRISPR technologies for precision cell engineering, announced today that co-founder Jennifer Doudna, Ph.D., and Rodolphe Barrangou, Ph.D., M.B.A., Chairman of Caribou's Board of Directors, have been named as two of the winners of the 2016 Canada Gairdner Awards for their contributions in CRISPR - Cas characterization and gene editing.

Caribou Biosciences is pioneering a new era of precision cell engineering and we are seeking talented and passionate individuals to help us in our mission to transform the development of new medical therapies and bio-based products.

Finally, his discussion covers the genetic manipulation of induced pluripotent stem cells (iPSCs) to derive NK cells engineered to express modified CD16A, and their potential for improving the efficacy of tumor - targeting therapeutic mAbs.

Caribou Biosciences, a developer of CRISPR - Cas9 technologies for precision cell engineering, today announced that it has closed an $ 11 million Series A financing round.

The result of this two - step gene modification — forcing expression of the receptor for NY - ESO - 1, and adding a blocker gene to nullify the effect of TGF - beta — is a super T cell engineered to both more effectively kill target cancer cells and to resist the tumor's attack.»

Relapsed or refractory chronic lymphocytic leukemia and acute lymphoblastic leukemia patients have shown durable responses of almost 2 years to a novel T - cell engineering technique developed at the University of Pennsylvania Perelman School of Medicine in Philadelphia.

San Diego, CA (December 9, 2008)-- Novocell, Inc., a stem cell engineering company, today announced a collaboration with renowned stem cell researcher Dr. Shinya Yamanaka of Kyoto University, Japan, to allow Novocell to explore the creation of human islet cells from induced pluripotent stem (iPS) cells.

These are exciting advancements, but the most viable method remains in vitro primordial germ cell engineering — making genome edits in germ cells in a «petri dish».

San Diego, CA (June 3, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent No. 7,541,185 with method claims covering the use of endoderm cells derived from human embryonic stem cells (hESCs) for drug discovery.

We also support he bespoke stem cell engineering team, which does not rely on LIMS systems so much owing of the nature of their work.

ViaCyte's scientists and other experts have published key findings in the field of stem cell engineering.

Hence, development of technologies capable of effectively overcoming these barriers for delivery of cell engineering materials, while preserving critical cell functions, is vital to success.

«Besides the applications this cell engineering and transplantation approach may find in regenerative medicine, our findings support the broader concept that enhancing the function of interneurons can counteract key aspects of Alzheimer's disease,» said Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease.

Remarkably, CD26high T cells engineered with a first generation CD3?

Novocell has three primary technologies: stem cell engineering, cell encapsulation and drug discovery.

San Diego, CA (November 25, 2008)-- Novocell, Inc., a stem cell engineering company, today announced that President and Chief Executive Officer Alan J. Lewis, Ph.D., will leave the company effective January 1, 2009 to become the President and CEO of the Juvenile Diabetes Research Foundation.

Novocell, Inc. is a stem cell engineering company with research operations in San Diego, California and Athens, Georgia, dedicated to creating, delivering and commercializing cell and drug therapies for diabetes and other chronic diseases.

The authors transplanted human cortical ‐ derived neural progenitor cells engineered to secrete glial cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the cells migrated, matured into astrocytes, and released GDNF.

Unmatched performance — high transfection efficiency & cell viability in primary cells Fully scalable — from R&D to the clinic without reoptimization Safe — non-viral cell engineering in closed, sterile, computer - controlled environment Cell loading flexibility — mRNA, gRNA, siRNA, DNA, proteins, cell lysates, and small molecules into autologous or allogenic immune, stem / progenitor, or somatic cells Regulatory ease — Master File designation with the CBER Division of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - marked

San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.

His gene therapy — delivering nanoparticles could transform patients into their own T - cell engineering labs, allowing them to be treated with reprogrammed T cells almost from the moment of diagnosis, skipping the waiting period and high cost of current approaches.

Mapping the expression profiles of all genes one cell at a time revealed unexpected heterogeneity in the stem cell - derived lung cells, and the research team at the CReM used this information to improve the airway cells engineered in the lab.

Tags for this Online Resume: cell engineering, gene expression optimization, molecular biology, ELISA, ForteBio, Microbiologst, R&D Scientist, Animal Models, Protein Chemistry, Cell Biology

Not exact matches

When Vancouver civil engineer James Dean started his greentech company, dPoint Technologies, in the early 2000s, he figured he could hitch his wagon to the promise of the hydrogen fuel cell sector.

Brendan Frey, CEO of Deep Genomics and a biomedical engineering professor at the University of Toronto, says his research team trained its system to analyze individual cells to draw conclusions about the entire cellular system and, ultimately, make a diagnosis.

«We have all the engineers» personal cell phone numbers, and they're listening to us,» says Davis, a former construction worker.

Drawing on his 20 years of engineering experience, Chamtech Technologies founder Anthony Sutera began experimenting and eventually created a liquid composed of nanoparticles, that when dried, could function as a highly efficient antenna — whether painted onto a building or injected directly into the molding of a cell - phone case.

One day in 2005, video - software engineer and entrepreneur Ted Schilowitz's cell phone rang.

Technology by Cellectis allows cellular engineering, and a human trial of the company's work in editing blood cells will be presented at the upcoming American Society of Hematology.