Sentences with phrase «patient stem cells used»

Not exact matches

According to Science Daily, Dr. Nagy, senior investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, there is a «new method of generating stem cells that does not require embryos as starting points and could be used to generate cells from many adult tissues such as a patient's own skin cells.»

These stem cells would be genetically identical to the patient from whom the original adult cell was taken and could be used for research and therapeutic purposes.

As we read this history, the furor over stem cells was fueled by numerous factors: the near - universal human desire for magic; patients» desperation in the face of illness and their hope for cures; the belief that biology can now do anything; the reluctance of scientists to accept any limits (particularly moral limits) on their research; the impact of big money from biotech stocks, patents, and federal funding; the willingness of America's elite class to use every means possible to discredit religion in general; and the need to protect the unlimited abortion license by accepting no protections of unborn human life.

Researchers used stem cells to create retinal pigment epithelium cells, which were transplanted into a patient's retina (left) in an area depicted by the black circle.

The Muotri lab uses induced pluripotent stem cells from patients with autism and schizophrenia to look for biomarkers of these conditions.

To solve this, West proposed «therapeutic cloning» — taking the nucleus out of a patient's cell, transferring it into an egg cell to create a cloned embryo, then using that embryo to derive patient - matched stem - cell lines.

«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for Human Development, Stem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explaStem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explCells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explastem cells to then be implanted back into the patient if they have a cartilage defect,» she explcells to then be implanted back into the patient if they have a cartilage defect,» she explains.

In the future the researchers see using stem cells taken from patients to grow new bones.

The Porteus team started with human stem cells from the blood of patients with sickle cell disease, corrected the gene mutation using CRISPR and then concentrated the human stem cells so that 90 percent carried the corrected sickle cell gene.

«We concluded that stem cells used in cardiac therapy should be drawn from healthy donors or be better genetically engineered for the patient.»

«If we win, the entire regulatory structure for autologous cell processing, with or without culture, will be rewritten such that any physician using good practices and treating patients responsibly can use stem cells as part of his or her medical practice,» he says.

But Christopher Centeno, Regenerative Sciences» medical director, argues that as the treatment uses a patient's own stem cells, it is a medical procedure akin to in vitro fertilization, and therefore none of the FDA's business.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Hamilton announced the newest organ - on - chip innovation, which recreates an intestinal lining using patient - derived stem cells, created through a partnership between Emulate and Cedars - Sinai Board of Governors Regenerative Medicine Institute.

«This work demonstrates the feasibility of using a single gene editing platform, plus the regenerative power of stem cells to correct genetic mutations and restore dystrophin production for 60 percent of Duchenne patients,» said Pyle, associate professor of microbiology, immunology and molecular genetics and member of the Broad Stem Cell Research Censtem cells to correct genetic mutations and restore dystrophin production for 60 percent of Duchenne patients,» said Pyle, associate professor of microbiology, immunology and molecular genetics and member of the Broad Stem Cell Research CenStem Cell Research Center.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

June 2008 was the first time a patient received a trachea transplant that made use of her own stem cells, in what was then the most advanced example of tissue engineering.

His optimism about stem cells and heart disease is unquenchable, and he talks up another project — to use stem cells to wean dying patients off heart machines.

Johns Hopkins is also starting a clinical trial using stem cells in heart attack patients.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.

Despite a lack of rigorous clinical trials to test safety or efficacy, a ban of the treatment by health authorities, and a lack of peer review by the scientific community, the privately funded Stamina Foundation has been using cultured mesenchymal stem cells that have been exposed to putative conditions that favour neuronal differentiation to treat different diseases in severely or terminally ill patients.

That message, delivered in two studies published today, is both good news and bad news for researchers who hope to use so - called induced pluripotent stem cells (iPS cells) to study diseases and perhaps some day treat patients.

Researchers have developed a new way to study bone disorders and bone growth, using stem cells from patients afflicted with a rare, genetic bone disease.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

Marbán and his clinical and research teams in 2009 performed the first procedure in which a heart attack patient's heart tissue was used to grow specialized stem cells that were injected back into the heart.

«There have been previous reports of other labs deriving beta cell types from stem cells, no other group has produced mature beta cells as suitable for use in patients,» he said.

Some patients, scientists, and politicians had dared hope that cloning technology could be used to create donor - compatible stem cells that can help treat disease.

Young - Pearse and colleagues believe that their strategy of using induced pluripotent stem cells to reprogram patient skin cells into neurons of interest could be used to predict which therapeutics will best help early onset Alzheimer's patients.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

Lanza previously led a clinical trial in the United States — published November 2014 in the Lancet — that demonstrated embryonic stem cells could be used safely for patients with degenerative eye diseases, but the patient sample was Caucasian with the exception of one African - American.

As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood - related conditions such as leukemia and sickle - cell disease.

Abatacept, when added to the standard drug regimen used to prevent GvHD, reduced the occurrence of acute, grade III - IV GvHD from 32 to 3 percent in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

The method, which involves inserting genetic material that makes the cells» development run backwards, opens the door to stem cells specific to patients, which could be used to repair damaged organs or fight diseases such as Parkinson's and diabetes — crucially, all without the need to destroy human embryos.

Using genetic analyses, the researchers showed that a commonly used cell line which was established in Uppsala, Sweden, almost fifty years ago does not originate from the patient it is claimed to stem from.

Three months after the Chinese health ministry ramped up its efforts to enforce a ban on the clinical use of unapproved stem - cell treatments, a Nature investigation reveals that businesses around the country are still charging patients thousands of dollars for these unproven therapies.

But if he were performing a stem cell transplant for a cancer patient who also happened to have AIDS, he reasoned, then why not use stem cells with the CCR5 deletion?

«Long - term remissions in some patients after stem cell transplants from donors have been observed, but treatment - related toxicity limits the widespread use of this therapy.»

The ultimate goal is to use stem cells of an individual patient and create a personalized model of their reproductive system.

«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.

A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.

Ultimately, the goal is to use stem cells of an individual patient and create a personalized model of their reproductive system to test new drugs for safety and effectiveness.

The existence of cancer stem cells has already been reported in a number of human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem cells have been shown to be unreliable and, in any case, do not reflect the «real situation» in an intact tumour in a patient.

Published in Stem Cell Reports, the study investigated the brain cell function of familial AD patients by using stem cell technologStem Cell Reports, the study investigated the brain cell function of familial AD patients by using stem cell technologCell Reports, the study investigated the brain cell function of familial AD patients by using stem cell technologcell function of familial AD patients by using stem cell technologstem cell technologcell technologies.

Umbilical cord blood, for example, generally contains insufficient numbers of stem cells for it to be used as a source of HSCs for transplantation into adult patients.

Using specimens collected annually in patients seen at Dr. Young's bone marrow failure clinic at the NIH Clinical Center, the investigators show that patients can support good blood cell production for many years from only a few stem cell clones, which can contain many unfavorable mutations.

This feature would be critical for clinical uses, such as transplanting stem cells — with their defects corrected — back into patients, but the researchers emphasize that years of further study remain before such treatments might be possible.

Zhao and his colleagues are also investigating whether a megakaryocyte niche can be used to help expand human hematopoietic stem cells in vitro and stem cell transplantation for patients.