Sentences with phrase «patients on those trials»

Patients on those trials had access to those drugs two years before anyone else.

Further research could test these cancer stem cell gene expression at the RNA and protein level in circulating tumor cells and biopsies from patients on trial.

Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small cell lung cancer on trials of ALK inhibitors and 355 similar patients on trials of immunotherapies directed at PD - 1.

Researchers will continue to follow patients on this trial to determine if dabrafenib alone or dabrafenib given in combination with trametinib is more effective long term.

Of those patients on the trial, 3.2 % had a complete response and 42.9 % had a partial response.

As part of our Melanoma Moon Shot, our team of clinicians and scientists work together to study blood and tumors that are collected from patients on these trials.

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

«Watson is able to give us faster, better matching of patients to potential clinical trials that our oncologists wouldn't have otherwise be able to see — and I sit with our oncologists who work on this kind of thing,» Christopher Ross, CIO at the Mayo Clinic, told MobiHealthNews in an interview.

With a critical mass of 450,000 patients annually among them, the six centers have agreed to combine their efforts on planning clinical trials in immunotherapy, recruit patients quickly, and share the information learned — which could be the single biggest factor in speeding up drug development.

In a 564 - person trial, patients whose ovarian cancer recurred (and who had already started treatment with chemotherapy) given Rubraca, part of a new class of cancer drugs called «PARP» inhibitors, lived, on median, for double the amount of time without their disease getting even worse compared with those given a placebo.

Merck multiple myeloma trials on hold after patient deaths.

Researchers from the Sichuan University in Chengdu inserted the re-engineered cells into a lung cancer patient participating in a clinical trial at the West China Hospital on October 28th, according to Nature.

By printing multiple lung airways — or any other afflicted organ — from a human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice of testing on animals and proceed to human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.

It can be everything from an über - helpful call - center rep to an oncology adviser, recommending cancer treatments on the basis of a patient's genetic profile and thousands of clinical trials and medical journal articles it has analyzed.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Juno asserted that the clinical hold on the ROCKET trial did not affect plans for its other CD19 - directed CAR T - cell product candidates, including JCAR017, for which the company has launched two clinical trials now recruiting patients.

In 2000 - 10 roughly 80,000 patients took part in clinical trials based on research that was later retracted because of mistakes or improprieties.

For the second time in 5 months, Juno Therapeutics has put a clinical hold on a Phase II trial of JCAR015 in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia due to patient deaths.

Juno Therapeutics is seeking to change the protocol for the Phase II ROCKET clinical trial of its acute lymphoblastic leukemia candidate JCAR015, which the FDA has placed on clinical hold following the deaths of three patients, two of them last week.

Zytiga's approval was based on trials showing a 38 % reduction in the risk of death in this subset of patients, an improvement that's clearly influencing doctor's use of the drug.

While trilaciclib has a huge potential market among cancer patients receiving standard chemotherapies, investors want to keep their eyes on an ongoing trial evaluating a triple - combination of Roche's (NASDAQOTH: RHHBY) Tecentriq, chemotherapy, and G1's candidate.

In collaboration with Indiana University and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), Intercept is supporting a blinded Phase 2 trial treating 60 patients with alcoholic hepatitis (NCT02039219 on clinicaltrials.gov).

[18] In hospital trials on 34 cardiac arrest patients in 2006 the normal rate of recovery and hospital discharge of 15 percent was increased to an incredible 80 percent.

Effects of remote, retroactive intercessory prayer on outcomes in patients with bloodstream infection: randomised controlled trial.

In this randomized, double - blind clinical trial, virgin coconut oil was the clear winner: «among pediatric patients with mild to moderate AD, topical application of virgin coconut oil for eight weeks was superior to that of mineral oil based on clinical (SCORAD) and instrumental (TEWL, skin capacitance) assessments.»

He has published seminal works on blood pressure management through his role in the BPLTTC and played leading roles in a series of trials that define the clinical management of patients with diabetes and chronic kidney disease.

Vaginal Birth After Cesarean Delivery: Deciding on a Trial of Labor After Cesarean Delivery (FAQ070) Labor Induction (FAQ154) Patient Education FAQs

In addition to clinicians focusing on patient care, we have clinicians who also are educators and scholars as well as translational or clinical trial scientists.

Help your patients with food allergies with educational materials and find information on food allergy clinical trials.

In areas where the patient's choice has a profound effect on outcome, random comparisons eliminating choice will give unreliable estimates of true differences.14 Therefore, in the Netherlands, where choosing between home or hospital birth is an integral feature of the system, randomised controlled trials between home birth and hospital birth would not produce generalisable results even if it were possible to mount such trials.

Tessa Jowell receives a standing ovation in the House of Lords, after she delivers moving speech on cancer care, appealing for patients to be able to trial treatments https://t.co/krOn1sstn2 pic.twitter.com/Fa 1bOJgKDi

On Thursday, in Dr. Taub's second day on the witness stand in Mr. Silver's corruption trial, Mr. Silver's lawyers took pains to show that Dr. Taub knew of no explicit arrangement to trade patient referrals for state grantOn Thursday, in Dr. Taub's second day on the witness stand in Mr. Silver's corruption trial, Mr. Silver's lawyers took pains to show that Dr. Taub knew of no explicit arrangement to trade patient referrals for state granton the witness stand in Mr. Silver's corruption trial, Mr. Silver's lawyers took pains to show that Dr. Taub knew of no explicit arrangement to trade patient referrals for state grants.

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.

Based on Han's presentation to the Depression Club, the group decided to move forward with a clinical trial in patients.

We need much larger trials, on more diverse populations, before we can start to make a difference to how patients are treated.»

The researchers trialed their system on a female patient who has locked - in syndrome, a form of almost total paralysis caused by brain lesions, at the Royal Hospital for Neuro - disability in London.

Six lipid - lowering trials randomized 4,449 patients, who previously had a heart attack or stroke or had extremely high baseline cholesterol levels and were on statin therapy, to receive either bococizumab (150 mg subcutaneously every 2 weeks) or placebo to determine the effects on LDL levels.

Two other multi-national trials randomized 27,438 patients to either bococizumab or placebo and were designed to evaluate the impact of the drug on cardiovascular outcomes, including nonfatal heart attack and stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death.

But sometimes, they also have the privilege of seeing a therapy they worked on go to clinical trials or even to patients.

In another trial treatment arm that focused on non-cirrhotic patients, 29 genotype 3 - infected patients were enrolled.

Novartis, for example, spent $ 43 million on a manufacturing facility in Morris Plains, New Jersey, and last week it released results from a lymphoma trial in which cells were frozen and flown to and from patients in 10 countries.

Based on promising pre-clinical studies, therapeutic trials blocking PD - L1 in HIV - infected patients have started.

Based on results of the current study described in a report online June 18 in the journal Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian cancer.

«Unfortunately, most clinical trials to date have focused on patients whose cognitive deficits are already mild to severe, and when the therapeutic opportunities in this late stage of the disease are minimal.

AveXis, Inc., a clinical - stage gene therapy company developing treatments for patients suffering from rare and life - threatening neurological genetic diseases, announced in July 2016 that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation for the treatment based on preliminary clinical results from the trial of AVXS - 101.

The CO-STAR (Hepatitis C Patients on Opioid Substitution Therapy Antiviral Response) trial sought to evaluate the efficacy and safety of elbasvir - grazoprevir for injection drug users.

The study looks at data on 26 side effects from a trial of approximately 10,000 patients and suggests that cases of muscle pain and weakness are unlikely to be directly caused by statins, but may instead be due to the so - called nocebo effect, where the expectation of side effects can make patients more likely to report them.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

Ophthalmologists at 10 sites nationwide tested the ring in a phase 2 clinical trial on patients with glaucoma or ocular hypertension.

It was originally developed by the Bavarian government and given to 150,000 German children in the 1970s; it has proved safe in more recent trials on HIV - positive people and stem - cell transplant patients.