Sentences with phrase «peri-ovulatory rosiglitazone»

The team found that the white wines had low binding affinities, but all the reds bound readily: the tendency of 100 millilitres of red wine — about half a glass — to bind to PPAR - gamma is up to four times as strong as the same tendency in the daily dose of rosiglitazone (Food and Function, DOI: 10.1039 / c0fo00086h).

They also showed that they could manipulate Klotho expression pharmacologically using the anti-diabetic drug rosiglitazone, which resulted in decreased levels of Wnt5A.

Importantly, while using rosiglitazone in conjunction with targeted therapy reduced tumor growth in both young and aged pre-clinical models, using rosiglitazone alone accelerated tumor growth in young models, while inhibiting it in aged ones.

Klotho is a secreted protein that can be measured in the serum of patients and this can help in determining which patients would benefit from rosiglitazone therapy and would be eligible for further studies.

«Previous studies had tested the use of rosiglitazone for cancer treatment, but the outcome was not encouraging.

Although both studies have limitations, an editorial accompanying Graham's paper considered the findings compelling: «Accumulating concerns about rosiglitazone make it difficultto advance a cogent argument regarding why, exactly, a patient might want to receive the drug.»

The researchers showed that a two - day treatment regimen with partial or selective PPAR - γ agonists (Telmisartan and Rosiglitazone — both FDA - approved drugs) ameliorated the pathological outcomes of infection in mice by inducing expression of glucose transporters.

The researchers showed that the type 2 diabetes drug rosiglitazone, which increases insulin sensitivity, also protects neurons from ADDLs.

In these mouse tests, WWL113 — without any optimization for use as a drug — performed about as well as the FDA - approved diabetes treatment rosiglitazone (Avandia).

«Our compound clears lipids from the diabetic mouse liver, whereas rosiglitazone has the opposite effect,» said Saez.

The latest case concerns GlaxoSmithKline's Avandia (rosiglitazone), an anti-diabetes drug linked to heart attacks.

Clinical trials of GlaxoSmithKline's diabetes drug Avandia (rosiglitazone) and Merck's anti-inflammatory Vioxx (rofecoxib) revealed an elevated cardiac risk from the drugs, but relevant findings were held back from regulators or never published.

However, it is commonly associated with diabetes, which has prompted researchers to test diabetes medications, such as metformin, rosiglitazone and liraglutide, as potential treatments.

Pini M, Rhodes DH, Castellanos KJ, Cabay RJ, Grady EF, Fantuzzi G. Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice.

Prolonged decrease of adipocyte size after rosiglitazone treatment in high - and low - fat - fed rats.

Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high - fat - fed mice.

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A - ZIP / F - 1 Fatless Mice

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

«Our post-trial analysis compared patients treated with rosiglitazone to patients not receiving any TZD drug.

«It's not a pure randomly assigned trial of rosiglitazone versus a different drug,» Bach says.

There is particular controversy surrounding rosiglitazone.

Taking either rosiglitazone or Lovaza with metformin seemed to mitigate some of the negative heart effects of metformin alone in men.

But women, already benefiting from metformin, improved heart metabolism further by adding rosiglitazone, with the desired effect of reducing the heart's dependence on fat metabolism.

Under McGill's supervision, the first group received metformin alone; the second received metformin plus rosiglitazone (Avandia); and the third received metformin plus Lovaza, which is a kind of fish oil.

The diabetes drug rosiglitazone has been under intense scrutiny since a 2007 study in the New England Journal of Medicine looked at more than 40 clinical trials and linked the drug's use with increased risk of heart attack and death from heart disease.

Peri-ovulatory Rosiglitazone treatment reverses impaired embryo development associated with obesity.

Metformin is also sold under the brand names Glucophage and Glucophage XR, and is found in pills that combine two types of antidiabetes medication, such as Glucovance and Metaglip (which combine metformin with a sulfonylurea drug) and Avandamet (a combination of metformin and rosiglitazone, a thiazolidinedione medication).

The researchers found that berberine performed as well as three well - known diabetes drugs — metformin, glipizide and rosiglitazone — and also helped to lower LDL cholesterol and triglycerides.

Pills to control blood sugar in people who have diabetes — like Avandia (rosiglitazone) or Actos (pioglitazone)-- make it harder to get sodium out of the body, which leads to swelling.

Rosiglitazone prevents the rise in net cell death.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

One big review of 14 studies found that berberine extracts are equally as effective at lowering insulin as the common diabetes drugs metformin, glipizide, and rosiglitazone.

Furthermore, rosiglitazone increased mortality in those with type 2 diabetes [34].

Furthermore, the best part is that the study is just one among dozens; a large review of 14 studies found that berberine is as effective as pharmaceutical oral diabetes drugs such as glipizide, metformin and rosiglitazone.

The only thing rosiglitazone drugs like Avandia do is to help lower blood glucose, which has virtually no influence on the long - term damage due to type 2 diabetes.

Avandia (rosiglitazone) is the poster child for what is wrong with the drug treatment of type 2 diabetes.

In the report, published in the December 2007 issue of Nature Medicine, researchers from the Salk Institute in La Jolla, California report that rosiglitazone (Avandia) has been shown to interfere with >> Read Article

-- «Resistin and Type 2 Diabetes: Regulation of Resistin Expression by Insulin and Rosiglitazone and the Effects of Recombinant Resistin on Lipid and Glucose Metabolism in Human Differentiated Adipocytes»; Philip G. McTernan et al; The Journal of Clinical Endocrinology & Metabolism; 2003

Rosiglitazone use was associated with a 25 % higher risk of heart attack.

Unexpectedly, rosiglitazone increased the risk of heart attacks.

By 2011, Europe, the UK, India, New Zealand and South Africa had all banned the use of rosiglitazone, although the FDA continued to allow its sales in the United States.

The Impact of a Drug Safety Warning on Discussions between Doctors and Their Patients; the Case of Rosiglitazone