Sentences with phrase «pharmacokinetic profile of»
This study aims to describe the pharmacokinetic profile of vinblastine in cats and to identify which characteristics or traits that can vary from one cat to another (e.g., age, kidney function, liver function) influence how vinblastine is distributed and eliminated in cats.
http://www.vetmed.ucdavis.edu/
The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.
Pharmacokinetic profile of J147 in mice.
(A) The pharmacokinetic profile of J147 in mice was done by Pharmaron (Louisville, KY, USA).
Since it is plausible that the unfavorable pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.
The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.
Not exact matches
«This is exactly the pharmacokinetic profile produced by lithium salicylate in our study,» said senior author Doug Shytle, PhD, also of the Center of Excellence for Aging and Brain Repair at USF Health.
According to Tomas Cihlar, Ph.D., of Gilead Sciences, the company is currently conducting phase I clinical studies of the compound in healthy human volunteers to establish the safety and pharmacokinetic profile.
Furthermore, in order to optimize the pharmacokinetic profile and to improve CXCR4 binding affinity of this class of molecules, dual pyrimidinyl compounds, substituted with different functional groups such as methoxy and morpholine, were synthesized (compounds 194 - 200).
One key aspect that her research group has devoted its efforts to over the past 15 years is expanding the toolkit of building blocks to include fluorinated aliphatic amino acids to improve the pharmacokinetic and physicochemical profiles of peptide / protein - based drugs and materials, respectively.
The ascending - dose, single - blind, placebo controlled, randomized trial will evaluate the safety as well as the pharmacokinetic and pharmacodynamic profile of DG041.
Proposed mechanisms of action for each drug, and known pharmacokinetic profiles in dogs are discussed.