Sentences with phrase «pharmacokinetic studies with»

Not exact matches

CT - P13 has previously demonstrated pharmacokinetic (PK) equivalence to INX in the PLANETAS trial, a randomised double - blind, parallel group study of 250 patients with AS, and was recently approved by the European Medicines Agency.

The investigators are currently designing a study to correlate pharmacokinetics, the time course of drug metabolism, with genotype.

A Phase 1 / 2a Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of PLX8394 in Patients with Advanced, Unresectable Solid Tumors

The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.

A Phase 1b / 2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of AMG 232 Combined with Trametinib and Dabrafenib or Trametinib in Adult Subjects with Metastatic Cutaneous Melanoma

A Phase 1b / 2 Open - Label Study to Evaluate Safety, Clinical Activity, Pharmacokinetics and Pharmacodynamics of Avelumab (MSB0010718C) in Combination with Other Cancer Immunotherapies in Patients with Advanced Malignancies

The prototype of such bis - macrocycles, plerixafor, was used in a recent study as a starting point for structural modification, in order to identify compounds endowed with a similar antiviral activity and improved pharmacokinetic properties [94].

The second study, FIREFISH, is aimed to assess safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy in infants with Type I SMA.

An Open - Label Multicenter Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B - 6527 in Subjects with Advanced Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

An Open - Label, Multicenter Phase I Study to Characterize the Safety, Tolerability, Preliminary Anti-Tumor Activity, Pharmacokinetics and Maximum Tolerated Dose of BAY 1251152 in Patients with Advanced Hematological Malignancies

A Multi-arm, Phase Ib, Open - Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination with Ascending Doses of Novel Therapeutics in Patients with EGFRm + Advanced NSCLC who have progressed following therapy with an EGFR TKI (TATTON)

Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267.

In this study, NPT088 was safe and well - tolerated at multiple dose levels, with a suitable pharmacokinetic profile.

Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA - 824 with concomitant lopinavir - ritonavir, efavirenz, or rifampin.

With the exception of IK14 (0.1 — 0.26 μg / mL), the values obtained (0.98 — 1.87 μg / mL) were above or consistent with expected trough values derived from our previous pharmacokinetic study [With the exception of IK14 (0.1 — 0.26 μg / mL), the values obtained (0.98 — 1.87 μg / mL) were above or consistent with expected trough values derived from our previous pharmacokinetic study [with expected trough values derived from our previous pharmacokinetic study [38].

Now, with the team's newly engineered human kidney glomerulus - on - a-chip, researchers also can get in vitro access to the kidney's core filtration mechanisms that are critical for drug clearance and pharmacokinetics, in addition to studying human podocytes at work.

The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.

This study established the MTD of the cyclophosphamide - huKS - IL2 combination (mainly limited by IL - 2 side effects), the pharmacokinetics of huKS - IL2 and its systemic immunologic and immunogenic effects in patients with solid tumors (BMC Cancer.

Since the proposed model may be used in further studies and the results of the study could be interpreted by people who are not familiar with the peculiarity of nicotine / cotinine pharmacokinetics in mice, we attempted to estimate the level of nicotine (and e-liquid vapor) exposure used in the discussed study.