American Federation for Aging Research Fellow at the Albert Einstein College of Medicine in New York; USA From: Salt Lake City, USA Prize Category: Translational Medicine Essay: A Novel Target for
Pharmacological Intervention in an Untreatable Human Disease
Category winner — Simon Johnson For his essay «A Novel Target for
Pharmacological Intervention in an Untreatable Human Disease» in the prize category Translational Medicine
«While much more research is needed, it is exciting to consider
that pharmacological intervention in these cellular processes might help slow or even prevent disease progression.»
Interestingly, Hobson has reservations about common
pharmacological interventions in brain function.
The four commonly used
pharmacological interventions in the figure are agomelatine, alprazolam, second - generation antidepressants and tricyclic antidepressants.
Not exact matches
Of course laboring women want to mitigate pain, but short of using
pharmacological interventions, how do you really reduce pain
in labor and birth?
Homeopathic remedies and knowing how to use them are an extremely helpful addition to any birth bag, whether you are going to have your baby
in hospital or at home and whether you are planning a normal birth without
interventions, a birth with
pharmacological pain relief or a caesarean birth.
In addition to traditional
pharmacological methods, a variety of behavioural
interventions involving the participation of the parents have been developed to reduce or eliminate undesirable sleeping behaviours.
During functional analysis, some of the responses known to occur
in the natural adult human heart were also elicited
in hECTs through electrical and
pharmacological interventions, while some paradoxical responses of hECTs more closely mimicked the immature or newborn human heart.
The delay
in diagnosis also prevents
pharmacological interventions from being initiated, and non-
pharmacological activities from being started, such as engaging
in diabetes education, discontinuing tobacco use, modifying dietary behaviors and increasing physical activity for improving cardiovascular health and stimulating weight loss.
These findings open up possibilities for future
pharmacological interventions aimed at enhancing muscle mass and function
in old age, and improving quality of life.
While major depressive disorder is one of the most common mental disorders
in children and adolescents, the use of
pharmacological intervention to treat it remains controversial.
This increase
in NAD levels is far superior compared with the 2-fold increases generally observed
in most genetic (PARP - 1 deletion),
pharmacological (NAD precursors), or physiological
interventions (fasting, calorie restriction) that enhance NAD content.
Pharmacological intervention is not the only answer to keep those glucose levels
in a better, and non-diabetic range.
In the following sections, we first provide an overview of treatment effects of non-
pharmacological and common
pharmacological treatments compared with inactive
interventions.
Reviews with a favourable conclusion about psychological therapies (vs
pharmacological interventions) are at high risk for a spin
in conclusions (OR = 8.31 (1.41 to 49.05)-RRB-, whereas favourable conclusions about effects of
pharmacological interventions showed no spin
in our sample (OR = 1.00 (0.16 to 6.14).
The new generation of
pharmacological treatment approaches to dementia attract most attention, but this study is a timely reminder that simple, early, psychosocial
interventions with caregivers can be cost effective
in maintaining patients at home, while not increasing strain on relatives.
All RCTs comparing any active
intervention (psychological
interventions,
pharmacological interventions or their combinations) with either active comparators or control conditions for acute treatment of depressive disorder
in children and adolescents will be included.
For the first time the efficacy, acceptability, tolerability and suicide - related outcomes of
pharmacological and psychological
interventions, alone or
in combination for depressive disorder
in children and adolescents will be comprehensively assessed
in a NMA.
Pharmacological interventions: L - methylfolate can not yet be recommended as an add - on treatment
in schizophrenia
What are the effects of psychological and
pharmacological interventions for depression
in coronary artery disease (CAD) patients with comorbid depression?
RCTs of psychological and / or
pharmacological interventions for depression
in adults with CAD and comorbid depression were included.
Are
pharmacological and non-
pharmacological interventions effective
in preventing relapse
in first - episode psychosis (FEP) patients?
Two RCTs reported cannabis use outcomes following
pharmacological interventions: one
in people with major depression, alcohol dependence and cannabis abuse diagnoses (n = 22; fluoxetine vs placebo) and one
in people with schizophrenia and cannabis and / or cocaine use disorders (n = 28; olanzapine vs risperidone).
Question: Are psychological or
pharmacological interventions effective for preventing child sexual abuse
in known abusers and individuals at risk of abusing?
Randomised controlled trials (RCTs) of
pharmacological or psychological
interventions reporting cannabis use outcomes
in people with psychotic or depressive disorders were included
in the review.
Do
pharmacological or psychological
interventions improve cannabis use outcomes
in people with psychotic or depressive disorders?
While the association between diet and ADHD symptoms is clear, dietary
interventions alone are not enough to treat the symptoms of ADHD, and are best used
in combination with
pharmacological and educational
interventions.