Sentences with phrase «pharmacological targeting of»

Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.

In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCs.

Not exact matches

This study reveals that the circadian clock is able to reprogram itself depending on a diet's nutritional content — which could lead to the identification of novel pharmacological targets for controlled diets.

In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic pain.

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.

New pharmacological approaches to target these changes will provide much needed and more effective treatments to reduce the power of drug - related associative memories that drive opiate addiction.

«The fact that the vitamin B12 - taurine - bone pathway affects only bone formation and appears to play the same role in mice and human beings raises the prospect that targeting this pathway through pharmacological means could be a novel approach toward an anabolic treatment of osteoporosis.»

The identification of these opiate - induced changes offers the best hope for developing more effective pharmacological targets and therapies to prevent or reverse the effect of opiate exposure and addiction.

«New drug targets for Ras - dependent cancers have long been sought,» said Arvin Dar, PhD, Assistant Professor of Oncological Sciences and Pharmacological Sciences at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and lead researcher on the study.

Previous studies had supported the possibility of targeting oncogenic forms of Ras via KSR, but no pharmacological approaches had been reported until now.

They're looking at the same types of pharmacological targets that maybe only used to be pursued at a drug company in the past,» says Philip Mayer, president of the American Association of Pharmaceutical Scientists in Arlington, Virginia.

Now, we can use copper - catalyzed conditions which are applicable to versatile fluoroalkenes to replace fluorine atoms with boron, which opens up a huge range of potential target molecules and should boost the use of fluoroalkenes in pharmacological studies.»

Noting that this anticipatory phase is often at the root of many people's sleeping problems, de Lecea suggested that the newly identified circuit could be a target for pharmacological intervention to help people ease into sleep.

He adds that the project «is just the beginning for the establishment of a new class of pharmacological entity, «sticky» biologics, characterized by localized, targeted activity.

The role of academic scientists in this process has largely been to explain the genetic / cellular basis of diseases for identifying useful targets and provide new chemical and computational methods to improve the pharmacological profile of potential drugs.

Such inhibition of fertility suggests that testes are exquisitely sensitive to disruption of retinoid signaling and that these receptors could be targets for pharmacological intervention of fertility (male contraception).

«The gender gap in mental health has been inadequately targeted and often only within the standard medical arsenal of pharmacological treatment,» Rojiani said.

Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice.

These are critical observations that will allow the field of autophagy to move beyond the utilization of lysosomal inhibitors for the pharmacological treatment of cancer by targeting autophagy.

American Federation for Aging Research Fellow at the Albert Einstein College of Medicine in New York; USA From: Salt Lake City, USA Prize Category: Translational Medicine Essay: A Novel Target for Pharmacological Intervention in an Untreatable Human Disease

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

He aims to develop sets of targets for selective pharmacological manipulation of circuitries involved in acquisition of fear and extinction learning.

Thus, Eph receptor - targeting peptides represent valuable pharmacological tools to study the functional importance of specific Eph receptors in tumors and the nervous system.

Since invasion is dependent on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by endothelial cells, namely, MMP - 2 and uPA could be other main key targets of the pharmacological action of kahweol on endothelial cells.

Any of these key steps can be a potential pharmacological target to inhibit angiogenesis and, hence, to treat angiogenesis - dependent diseases [9].

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Under normal conditions, deletion of the transporter does not lead to any noticeable phenotype, suggesting that pharmacological or biological blockade of the transporter for therapeutic purposes is not likely to elicit significant off - target effects in normal tissues.

Current knowledge suggests that the majority of biologically active compounds interact with multiple molecular targets exhibiting pleiotropic pharmacological actions.

Despite more than half a century of intensive research, however, insulin - degrading enzyme has remained «an especially elusive pharmacological target,» biochemist Malcolm Leissring of the Scripps Research Institute and neurobiologist Dennis Selkoe of Harvard Medical School wrote in a commentary that accompanies the Nature article.

Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension.

Furthermore, as novel pharmacological targets, the vanilloid receptors have potential for the development of many future disease treatments.

According to the National Institute of Mental Health, pharmacological treatments are often prescribed based on specific target symptoms shown by the individual patient.