Sentences with phrase «phase i trials of»

The Finnish drug maker on Sunday presented results from phase I trial of a prostate cancer treatment, saying according the data it «has been well tolerated, with no significant treatment - related adverse events.»

Trial # 2: Phase I trial of HCQ with dose - intense temozolomide in patients with advanced solid tumors and melanoma

One phase I trial of an immune checkpoint blockade drug combined with two established targeted therapies yielded 40 - 50 percent response rates among patients with metastatic kidney cancer.

In a few weeks, meeting participants learned, enough data may be available from small phase I trials of a vaccine jointly made by the U.S. National Institute of Allergy and Infectious Diseases and GlaxoSmithKline (GSK) that began in September to launch efficacy studies.

A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease.

[4] Sabbatini P, Tsuji T, Ferran L, Ritter E, Sedrak C, Tuballes K, Jungbluth AA, Ritter G, Aghajanian C, Bell - McGuinn K, Hensley ML, Konner J, Tew W, Spriggs DR, Hoffman EW, Venhaus R, Pan L, Salazar AM, Diefenbach CM, Old LJ, Gnjatic S. Phase I trial of overlapping long peptides from a tumor self - antigen and poly - ICLC shows rapid induction of integrated immune response in ovarian cancer patients.

Choy, H, Chakravarthy, A. Phase I trial of Irinotecan and concurrent radiation therapy for stage III non-small cell lung cancer.

«The impressive and durable response of the single patient with follicular lymphoma on the phase I trial of this agent spoke to its potential in this disease,» Westin added.

The clinical consortium is led by AFFiRiS itself, and in addition to the PD booster trial, it is now recruiting for a separate Phase I trial of the α - synuclein vaccine against MSA, a synucleinopathy differentiated from PD or LBD based on the cell populations affected, the regional concentration of AS neuropathology, and the spectrum of movement and other symptoms.

PD01A: Promising Animal Efficacy; Initial Human Safety and Hints of Disease Modification At the time of our last post on α - synuclein vaccines, AFFiRiS had published several papers about the AFFITOME immnotherapy discovery platform [8 - 11] and had even begun their first Phase I trial of PD01A, but had kept nearly silent on many of the most elementary aspects of the vaccine.

Senderowicz AM, Headlee D, Stinson SF, et al: Phase I trial of continuous infusion flavopiridol, a novel cyclin - dependent kinase inhibitor, in patients with refractory neoplasms.

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors (NCT02564198).

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors -LRB-

A phase I trial of the H3.3K27M - specific peptide vaccine combined with poly - ICLC for newly diagnosed H3.3K27M - positive diffuse intrinsic pontine glioma (DIPG) and other newly diagnosed H3.3K27M - positive gliomas (NCT02960230).

A phase I trial of anti-HER2 CAR T cells for subjects, including pediatric patients, with advanced sarcoma (NCT00902044).

She is the Protocol Chair for RV329: African Cohort Study; RV262, an international Phase I DNA / MVA HIV vaccine trial; and for RV398, an upcoming Phase I trial of the VRC01 broadly neutralizing monoclonal antibody administered in acute HIV infection in East Africa and Thailand.

A phase I trial of the H3.3K27M - specific peptide vaccine combined with poly - ICLC for newly diagnosed H3.3K27M - positive diffuse intrinsic pontine glioma (DIPG) and other newly diagnosed H3.3K27M - positive gliomas -LRB-

A phase I trial of anti-GPC3 (glypican - 3) CAR T cells along with lymphodepleting chemotherapy for patients with pediatric solid tumors (NCT02932956).

And the company just filed an application to begin Phase I trials of its ALAS - 1 targeting treatment for hepatic porphyrias (a class of rare inherited disorders that are the result of deficiencies in some enzymes of the liver), according to the release.

A combination of the indoleamine 2,3 - dioxygenase 1 (IDO1) inhibitor epacadostat with the anti — programmed death ligand 1 (PD - L1) antibody durvalumab was well tolerated in a phase I trial of patients with multiple solid tumor types.

Not exact matches

The penalty phase of the trial, which will decide whether Dzhokhar gets put to death, will begin next week.

In a research and strategy update, Novo said it will initiate a phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 2018.

So, at the end of the day, are companies simply flocking to disease areas like oncology, and rare diseases — which have low chances of approval from phase one trials due to their complexities but carry high margins and high rewards if they do cross the regulatory finish line — at the expense of other conditions?

During the sentencing phase of Tsarnaev's trial in federal court in Boston, his lawyers have been trying to paint him as a mostly normal American kid who fell under the spell of his now - deceased older brother, ultimately joining him in the 2013 bombing of the Boston Marathon.

The jury spent a total of just 14 hours in the penalty phase of the trial after finding Tsarnaev guilty on all 30 criminal counts, but an automatic appeal means his case will drag on.

The startup is in the midst of several clinical trials and completed a 52 - week Phase II clinical trial of an osteoarthritis treatment in July.

Acceleron is also advancing its neuromuscular franchise with two distinct Myostatin + agents, ACE - 083 and ACE - 2494, and a pulmonary program with a Phase 2 trial of sotatercept planned in pulmonary arterial hypertension.

Inovio's vaccine against HPV is currently in Phase II clinical studies, and Kim says «about 50 percent» of the subjects in that trial are defeating the disease.

«You look at a lot of ideas, rejecting most of them, flirting with a few, and then — hopefully — settling in for a trial phase with the most attractive and well - rounded option,» he writes in his book.

In November, the company announced that the results of a Phase III trial of solanezumab «were not what we had hoped for.»

The case is now in the discovery phase of trial and likely to be settled; he has denied wrongdoing.

According to PhRMA, there are more than a dozen experimental treatments that are still in phase 3, the latest stage of clinical trials before companies present their data to the FDA.

Trimel expects to complete Phase 2 trials in the first half of the year.

More than 4,000 individuals have voluntarily received the rVSV - ZEBOV vaccine as part of the Phase 3 trial which began in March, according to Merck.

Two out of the six obesity projects currently in Phase 1 trials are expected to move to Phase 2 next year, Novo said.

In a research and strategy update, Novo said it planned to start a final phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 2018.

Ms. Albarus testified in both phases of Malvo's trial.

And while the first phase of the trial was at times grueling for members of the jury - several breaking into tears as they listened to descriptions of the chaos near the Marathon finish line - the second phase could be even more so.

Reldesemtiv is the subject of three ongoing Phase 2 clinical trials enrolling patients with spinal muscular atrophy, chronic obstructive pulmonary disease and amyotrophic lateral sclerosis.

Omecamtiv mecarbil is the subject of GALACTIC - HF, an international Phase 3 clinical trial in patients with heart failure.

Cassidy said in the next phase of the trial they hope to get up to 300 balloons forming a ring on the 40th parallel south from New Zealand through Australia, Chile, Uruguay, Paraguay and Argentina.

Allergan and Paratek Pharmaceuticals are celebrating the success of sarecycline, an experimental acne treatment that met the primary endpoints in a pair of crucial phase 3 clinical trials.

The results, which mirror those of similar, small - scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer.

March 30, 2017 — Aura Biosciences Announces Initiation of Phase 1b Clinical Trial and Receipt of FDA Fast Track Designation for AU - 011 for the Treatment of Primary Ocular Melanoma

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

Defense attorneys pointed to Tamerlan's relationship with his wife to demonstrate his ability to influence his younger brother Dzhokhar, as they began their case Monday in the sentencing phase of Dzhokhar's trial.

Juno Therapeutics will resume its Phase II ROCKET clinical trial of its acute lymphoblastic leukemia candidate JCAR015 following the FDA's lifting of a partial clinical hold imposed last week following the deaths of three patients.

For the second time in 5 months, Juno Therapeutics has put a clinical hold on a Phase II trial of JCAR015 in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia due to patient deaths.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Juno Therapeutics is seeking to change the protocol for the Phase II ROCKET clinical trial of its acute lymphoblastic leukemia candidate JCAR015, which the FDA has placed on clinical hold following the deaths of three patients, two of them last week.