Sentences with phrase «phase ii»

But it was ultimately abandoned after a reformulated version used in the Phase II trial triggered meningoencephalitis in some 6 % of patients.

A humanized monoclonal antibody, now approved for use in metastatic melanoma, showed activity in a phase II trial with RCC.

ARRY - 520, a novel selective kinesin spindle protein (KSP) inhibitor showed promising clinical activity both alone and combined with low - dose dexamethasone in a phase II clinical trial in patients with relapsed and refractory multiple myeloma.

Another modified peptide POL6326 is in phase II clinical trial in hematopoietic stem cell mobilization in multiple myeloma [128].

Phase II study of cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second - line therapy of small cell lung cancer (NCI # 7097).

As of early 2012, clinical trials of IL - 17 antibodies against psoriasis have shown promising results in Phase II.

We are now moving this discovery into Phase II clinical trials (FDA approved) in patients suffering ischemic damage to the heart.

The phase II portion enrolled 49 patients with untreated MDS / CMML / AML of any age receiving first salvage treatment for AML with a FLT3 - ITD mutation.

deCODE genetics (Nasdaq: DCGN) today announced positive results from its preliminary Phase II clinical trial (Phase IIa) of Cephalon Inc.'s (Nasdaq: CEPH) CEP - 1347 in asthma.

Current clinical trials include combination of intrahepatic embolization and a radiosensitizer in patients with uveal melanoma and liver - only metastases, a phase I trial that evaluates a combination therapy of BCG with ipilimumab in Stage III / IV melanoma, and several landmark international trials including a phase II trial that evaluates combination immunotherapy with nivolumab & ipilimumab.

Reykjavik, ICELAND, December 17, 2004 — deCODE genetics (Nasdaq: DCGN) today announced the signing of an agreement under which it will conduct a Phase II information - rich clinical trial next year of a third - party compound as part of a drug development program in asthma.

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy - refractory, advanced colorectal cancer.

GigaGen seeks a talented, highly motivated Research Assistant to work alongside PhD - level scientists on research funded by a $ 50 million co-development deal with Grifols, plus Phase II SBIR grants from the NCI and NIAID.

The combination of rituximab (Rituxan) and the novel immunotherapy pidilizumab (CT - 011) is both active and well tolerated in follicular lymphoma patients, according to results of a phase II trial presented by Jason R. Westin, MD, of the MD Anderson Cancer Center in Houston, at the American Society of Hematology (ASH) meeting in Atlanta.

NEWARK, Calif., May 31, 2016 (GLOBE NEWSWIRE)-- StemCells, Inc. (NASDAQ: STEM)(the «Company») today announced its decision to terminate the Company's Phase II Pathway Study in spinal cord injury following an in - depth review of data from the study and after obtaining the concurrence of the study's Interim Analysis Data Monitoring Committee (the «IA - DMC»).

The researchers noted that initial clinical trial data have been validated in larger phase II trials in the setting of relapsed / refractory HL, non-Hodgkin's lymphoma (NHL), and multiple myeloma (MM).

Currently TLK - 199 is in Phase II of the Food and Drug Administration's (FDA's) clinical trial for the treatment of myelodsyplasitc syndromes (MDS).

In a recent multi-institutional phase II trial of Onyx - 015 led by investigators at University of Texas M.D. Anderson Cancer Center, 30 patients with advanced head and neck cancer, most of whom had failed surgery or radiation therapy, were treated.

The investigators pooled the safety data from the phase I JAVELIN Solid Tumor trial, which included 1,650 patients, and the phase II JAVELIN Merkel trial (88 patients); the agent was also approved in early 2017 for the treatment of metastatic Merkel cell carcinoma.

A randomized, phase II trial showed improved progression - free survival in small - cell lung cancer with maintenance sunitinib vs placebo following standard chemotherapy, according to results presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

He is a member of the High Risk Neurobalstoma Committee of COG, institutional performance review committee for COG Phase - I consortium and is the Principle Investigator of the Children's Oncology Group, Phase - I, Phase II - III Consortium studies at C.S. Mott Children's Hospital.

GigaGen seeks a talented, highly motivated Senior Scientist in Immunology to work on cutting - edge research funded by a $ 50 million co-development deal with Grifols, plus Phase II SBIR grants from the NCI and NIAID.

Final results of a cohort from a phase II monotherapy trial of quizartinib in acute myeloid leukemia patients showed that more than half of patients 60 years of age and older who harbored an internal tandem duplication in the FMS - like tyrosine kinase 3 had a composite complete remission.

Shah noted that cerebral edema has also been observed in clinical trials — among 6 ALL patients participating in the JUNO trials (and in 1 patient with non-Hodgkin lymphoma treated in the ZUMA - 1 phase II registration trial).

An Open Label, Multicenter, Single Arm Phase II Pilot Study to Evaluate the Efficacy and Tolerability of the Novel mTOR Inhibitor, MLN0128 (TAK - 228), in Patients with Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelial Tract whose Tumors Harbor a TSC1 and / or a TSC2 Mutation

Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II / III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC # 737754, IND # 118613)

A Phase II Trial of Atezolizumab (Anti-PDL1) with Carboplatin in Patients with Metastatic Triple Negative Breast Cancer

A Phase II Basket Study of the Oral TRK Inhibitor LOXO - 101 in Subjects with NTRK Fusion - Positive Tumors

She is CEO of PsychoGenics Inc., a profitable preclinical CNS service company, CEO of PGI Drug Discovery LLC, a company engaged in psychiatric drug discovery with three partnered Phase II clinical programs and Adjunct Associate Professor of Neuroscience at Mount Sinai School of Medicine, Dr. Leahy has more than 25 years of experience in drug discovery, clinical develop and business development for pharmaceutical and biotechnology companies, including extensive knowledge of technology assessment, licensing, mergers and acquisitions, and strategic planning.

Randomized Phase II Study: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis after Radiosurgery for Brain Metastases

CT - 011, developed by Israel - based Curetech Ltd, is also being tested in phase II trials in metastatic melanoma, colorectal cancer in combination with chemotherapy, advanced renal cell and prostate cancers, as well as in acute myeloid leukemia.

A second product for therapeutic vaccination in HIV is in phase II development.

The companies have launched a phase II trial of the antibody - drug conjugate, and are also testing it in other solid tumors, including ovarian and non — small - cell lung cancers.

Meta - analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression - free and overall survival benchmarks for future phase II trials.

PELOPS: Palbociclib and Endocrine Therapy for Lobular Breast Cancer Preoperative Study: A Randomized Phase II Study of Palbociclib with Endocrine Therapy versus Endocrine Therapy Alone for Invasive Lobular Carcinoma and Invasive Ductal Carcinoma

A Randomized, Double - Blinded, Phase II Study of Maintenance Pembrolizumab versus Placebo after First - line Chemotherapy in Patients with Metastatic Urothelial Cancer

November 23, 2011 — The International Cooperation to Sequence the Atlantic Salmon Genome (ICSASG, the «Cooperation») has awarded the Phase II contract for next - generation sequencing and analysis of the Atlantic salmon genome to the J. Craig Venter Institute (JCVI) in Rockville, Maryland.

An Open Label, Phase II Study of Neratinib in Patients with Solid Tumors with Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification

Daniel Alan Perley, Socorro High School, Socorro, New Mexico Dynamic Formation of Tidal Structure in Interacting Galaxies as Determined by Newtonian Model Computer Simulations: Phase II

Phase II / III Biomarker - Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer

A Phase II Single - Arm Trial to Investigate Tepotinib in advanced (Stage IIIB / IV) Non-Small Cell Lung Cancer with MET Exon 14 (METex14) Skipping Alterations After Failure of at Least One Prior Active Therapy, Including a Platinum - Doublet - Containing Regimen

Phase II, funded by NIBIB, sustained the training programs through their critical early years

Phase III trials involve thousands of participants and occur only after the experimental vaccine has successfully moved from a Phase I and Phase II trial.

Finch expects to begin enrolling for a Phase II clinical trial to evaluate the safety and efficacy of FIN - 403 for the prevention of recurrence in recurrent C. difficile patients in the second half of 2017.

The goals of Phase II trials are usually to learn more about vaccine safety and to see if the vaccine generates an immune response.

A Phase II Trial of Pevonedistat and Azacitidine in MDS or MDS / MPN Patients Who Fail Primary Therapy with DNA Methyl Transferase Inhibitors

This phase II trial studies how well chemotherapy and radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors.

14145: Phase II Randomized Trial of Transoral Surgical Resection Followed by Low - dose or Standard - dose IMRT in Resectable p16 + Locally Advanced Oropharynx Cancer

Up to $ 150,000 for Phase I awards and $ 1,000,000 for Phase II awards; Phase I can be up to 2 years and Phase II up to 3 years duration

Chemotherapy Alone as Initial Treatment for Primary CNS Lymphoma in Patients Older Than 60 Years: A Multicenter Phase II Study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group