Sentences with phrase «phosphatase in»

The amylase, bacterially - produced lactase, lipase and phosphatase in raw milk, break down starch, lactose, fat (triglycerides) and phosphate compounds respectively, making milk more digestible and freeing up key minerals.

Ohkubo et al. «Ecto - Alkaline Phosphatase in NG108 - 15 Cells: A Key Enzyme Mediating P1 Antagonist - Sensitive ATP Response», British Journal of Pharmacology, 131 (8): 1667 - 1672, 2000.

Starvation and Diabetes Reduce the Amount of Pyruvate Dehydrogenase Phosphatase in Rat Heart and Kidney

Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways.

But, others say more work is needed to fully comprehend the role of prostatic acid phosphatase in viral transmission.

Not exact matches

Low dietary copper increases fecal free radical production, fecal water alkaline phosphatase activity and cytotoxicity in healthy men.

In particular, protein tyrosine phosphatase, receptor type, F (PTPRF) may serve as a biomarker linking insulin resistance with insufficient milk supply.

In this study, it is shown that dephosphorylation of Tyr15 triggered activation of the pp34 - cyclin complex from fission yeast, that a human protein - tyrosine phosphatase can catalyze this event both in vitro and in vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylatioIn this study, it is shown that dephosphorylation of Tyr15 triggered activation of the pp34 - cyclin complex from fission yeast, that a human protein - tyrosine phosphatase can catalyze this event both in vitro and in vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylatioin vitro and in vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylatioin vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylation.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - FoIn this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Foin a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

Ovaa and Neefjes» team decided to look at another class of proteins, called phosphatases, that act in the opposite way from kinases to see if inhibiting them would have a similar effect.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Dopamine and adenosine 3 ′, 5 ′ - monophosphate — regulated phosphoprotein (32 kilodaltons)(DARPP - 32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor.

It is an enzyme — one in a «superfamily» of 105 called protein tyrosine phosphatases (PTPs)-- that perform the essential biochemical task of removing phosphate groups from amino acids called tyrosines in other proteins.

In C. follicularis and N. alata, basic chitinases and purple acid phosphatases share numerous identical or highly similar amino acid substitutions that don't occur in non-carnivorous species, suggesting that these alterations may help these enzymes function in special, carnivorous wayIn C. follicularis and N. alata, basic chitinases and purple acid phosphatases share numerous identical or highly similar amino acid substitutions that don't occur in non-carnivorous species, suggesting that these alterations may help these enzymes function in special, carnivorous wayin non-carnivorous species, suggesting that these alterations may help these enzymes function in special, carnivorous wayin special, carnivorous ways.

In animals harboring intraperitoneal hollow - fiber or subcutaneous implants containing light - inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote - controlled with fiber optics or transdermally regulated through direct illumination.

«All sorts of reactions in cells are controlled by modifying proteins with kinases and phosphatases,» said Keating.

«Two components of the pathway, the phosphatase PTPD2 and the lipid PA, are together required for HER2 signaling to function in mammary epithelial cells.»

Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes: protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.

The phosphatases are also promising targets for therapeutic intervention in the treatment of various cancers,» Dr. Varjosalo states.

The human protein phosphatases are illustrated in the form of the most well studied phosphatase, the protein phosphatase 2A (PP2A).

A mutation in one of the genes that controls this pathway, PTEN (also known as phosphatase and tensin homolog), can cause a particular form of autism called macrocephaly / autism syndrome.

Pten (short for phosphatase and tensin homolog) is a tumor suppressor that is defective in about 20 - 25 percent of all patients with cancers.

In a paper published by Scientific Reports today, the research team found the activity of this protein, called PTEN (for Phosphatase and tensin homolog deleted on chromosome 10), is different between men and women.

Total proteins were harvested in lysis buffer (20 mM Tris - HCl [pH 8.0], 150 mM NaCl, phosphatase inhibitors [Pierce], protease inhibitors [C complete protease inhibitor cocktail, Roche], and 1 % Triton X-100).

The researchers also determined that SMEK1 doesn't act alone: it works in concert with Protein Phosphatase 4 to suppress the activity of a third protein called PAR3 that discourages neurogenesis, or the birth of new neurons.

Other data obtained in this report (BrdU nitroblue tetrazolium staining by alkaline phosphatase and fluorescence due to fluorescein) would further suggest that putative stem cells are located in the posterior limbus between the peripheral endothelium and the trabecular meshwork.

Since alkaline phosphatase, coupled to the secondary antibody for the BrdU primary antibody, may have complicated the interpretation of the wounding experiments, we also treated human corneal - limbal tissues with BrdU histochemical assays in which fluorescein, rather than alkaline phosphatase, was coupled to the secondary antibody.

They show that it is a substrate for calcineurin, the phosphatase target of the immunosuppressive drugs cyclosporin A and FK506, and that it exists in activated cells as a complex with the transcription factor AP - 1 (Fos - Jun).

In the last stage they were exposed to an alkaline phosphatase substrate (nitroblue tetrazolium phosphate) and examined by light microscopy.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

It is also pointed out that donor age (beyond 45 years in the alkaline phosphatase - linked BrdU assays) may also have limited the human wounding response (cell division) in the corneal periphery.

PTEN phosphatase - independent maintenance of glandular morphology in a predictive colorectal cancer model system.

The data presented in this report (telomerase activity and BrdU - linked alkaline phosphatase activity staining) suggests that cells in the corneal endothelium may be renewed by stem - like cells located in a niche at the posterior limbus.

Carboxy - terminal domain phosphatase 1 silencing results in the inhibition of tumor formation ability in gastric cancer cells.

The association between BPA and the three liver enzymes previously examined were not statistically significant in age, sex and ethnicity adjusted models (Table 4) or fully adjusted models (Table 5) in 2005/06, although overall associations in the pooled data were still present for alkaline phosphatase (logged ALP association with per - SD increase in BPA concentration beta = 0.02, CI: 0.01 to 0.03, p = 0.002) and lactate dehydrogenase (beta = 0.01, CI: 0.003 to 0.02, p = 0.009).

However, in this case the secondary antibody was linked to fluorescein to avoid the possibility that cellular alkaline phosphatase itself may have contributed to the final results.

Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae.

Thrombin - induced endothelial barrier disruption in intact microvessels: role of RhoA / Rho kinase - myosin phosphatase axis.

The microRNA cluster miR - 183 / 96/182 contributes to long - term memory in a protein phosphatase 1 - dependent manner.

BrdU staining with alkaline phosphatase was occasionally observed in the wounded area's human corneal endothelial cells after wounding.

Research Focus: My research projects are focused on the roles of protein tyrosine phosphatases (PTPs) in diabetes and rheumatoid arthritis.

The inositol 5 - phosphatase SHIP - 1 and adaptors Dok - 1 and 2 play central roles in CD4 - mediated inhibitory signaling % U http://www.sciencedirect.com/science/article/pii/S0165247812000594.

Reduced levels of Dusp3 / Vhr phosphatase impair normal spindle bipolarity in an Erk1 / 2 activity - dependent manner.

Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.

That, in turn, activates an inducible reporter gene, which expresses a secreted form of alkaline phosphatase.

Phosphatase and tensin homologue (PTEN)- induced putative kinase 1 reduces pancreatic β - cells apoptosis in glucotoxicity through activation of autophagy.

Kinases and phosphatases are enzymes that add or remove, respectively, negatively charged phosphate - oxygen groups to other molecules in the cell.

Tyrosine phosphatase inhibitor triggers rodlet cell discharge in sunfish scale epidermis cultures.

The inositol 5 - phosphatase SHIP - 1 and adaptors Dok - 1 and 2 play central roles in CD4 - mediated inhibitory signaling.