Phosphoinositides in Ca2 + signaling and excitation - contraction coupling in skeletal muscle: an old player and newcomers.
Not exact matches
Surprisingly, mobility of
phosphoinositides was nearly completely frozen
in these BAR domain induced lipid platforms.
Research
in the Emerling Lab is focused on
phosphoinositide signaling,
in particular the role of the phosphatidylinositol -5-phosphate 4 - kinases (PI5P4Ks)
in cancer metabolism.
Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses
in < i > Drosophila % U http://www.sciencedirect.com/science/article/pii/S1074761312000970.
Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses
in < i > Drosophila .
Decreased amounts of the lipid family of
phosphoinositides (PIPs)
in the plasma membrane have been shown to cause cytokinesis defects.
Investigators compared WR321, a non-human monoclonal IgG antibody that binds to
phosphoinositide lipids, developed by Dr. Gary Matyas at MHRP, with a human monoclonal IgG antibody that
in recent studies was found to have lipid - binding characteristics, including binding to
phosphoinositides, but also bound to numerous other lipids.
«For the first time, it appears that a monoclonal antibody that binds only to highly purified intracellular
phosphoinositide lipids, and not to any of 17 other types of lipids or to HIV protein, results
in the secretion of HIV - inhibitory beta - chemokines.»
Although
phosphoinositides are also constituents of HIV,
in the absence of HIV they are located only inside cells,» said lead investigator Carl Alving, M.D. with the Division of Retrovirology at the Walter Reed Army Institute of Research.
This leads to activation of a kinase; a very important kinase
in metabolism called PI3 - Kinase, standing for
phosphoinositide or 3 - Kinase.
Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with
phosphoinositide - 3 kinase inhibitors
in cutaneous T - cell lymphoma
Inhibitory role of alpha6beta 4 - associated erbB - 2 and
phosphoinositide 3 - kinase
in keratinocyte haptotactic migration dependent on alpha3beta1 integrin.
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule
in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R,
Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1,
phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K,
phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched
in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting
PLC - beta is a 150 kDa enzyme that catalyzes the hydrolysis of
phosphoinositide PtdIns (4,5) P2 located
in the plasma membrane into diacylglcyerol (DAG) and
Ins (1,4,5) P3.
In addition, leucine has been shown to modulate insulin / phosphoinositide 3 - kinase signaling in animal models (10), and cysteine has been shown to increase glucose uptake and concentrations of glucose transporter 3 and glucose transporter 4 in vitro; in rat models, dietary cysteine has been shown to reduce insulin resistance and glucose intolerance (11, 12
In addition, leucine has been shown to modulate insulin /
phosphoinositide 3 - kinase signaling
in animal models (10), and cysteine has been shown to increase glucose uptake and concentrations of glucose transporter 3 and glucose transporter 4 in vitro; in rat models, dietary cysteine has been shown to reduce insulin resistance and glucose intolerance (11, 12
in animal models (10), and cysteine has been shown to increase glucose uptake and concentrations of glucose transporter 3 and glucose transporter 4
in vitro; in rat models, dietary cysteine has been shown to reduce insulin resistance and glucose intolerance (11, 12
in vitro;
in rat models, dietary cysteine has been shown to reduce insulin resistance and glucose intolerance (11, 12
in rat models, dietary cysteine has been shown to reduce insulin resistance and glucose intolerance (11, 12).
One of the serine / threonine protein kinases (JGI ID: 432478) was upregulated nearly sevenfold
in the future ocean condition treatment, whereas a
phosphoinositide phospholipase C (JGI ID: 95985) increased expression sixfold (see electronic supplementary material, table S5).