Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.
Not exact matches
Joseph Castellano at Stanford University in California and his colleagues discovered this by collecting blood
from people at three different life stages — babies, young people around the age of 22, and
older people around the age of 66 — and injecting the
plasma component into
mice that were the equivalent of around 50 years
old in human years.
When Wyss - Coray's team tried a simpler experiment than parabiosis — giving
old mice injections of
plasma from young
mice — they saw similar effects on the hippocampal neurons.
It was one of the most mind - bending scientific reports in 2014: Injecting
old mice with the
plasma portion of blood
from young
mice seemed to improve the elderly rodents» memory and ability to learn.
When Yousef injected
plasma from people in their late 60s into the bodies of 3 - month -
old mice — about 20 years
old in human terms — the
mice's brains showed signs of ageing.
The inoculum was obtained
from old diabetic
mice (fasting
plasma glucose > 360 mg / dl), following a similar experimental paradigm as presented in Fig. 3.
Old mice getting
plasma from young animals performed better than those receiving
plasma from other elderly
mice.
The researchers also treated
old mice with 8 injections of blood
plasma taken
from either young
mice or other geezers.