Sentences with phrase «playing with genes»

Not exact matches

There was bound to be a two - season honeymoon in a state with the hockey gene — 40 % of season - ticket holders play the game — but the connection has mutated into something profound.

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Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

Finn Miller, a toddler born with Beckwith - Wiedemann syndrome, due to abnormal «imprinting» of genes, plays at home with his mother and older brother.

The fact that so many proteins interact with the 26 bait proteins indicates that these original proteins play key roles in a complex process that wasn't apparent on the level of the «suspect» genes.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

Mice with mutations in what is called the nude gene don't fully develop the thymus, a small organ in the chest cavity that plays a key role in the maturation of infection - fighting T cells.

Many hundreds of genes are likely to be involved, with each one playing a role in just a small fraction of cases, and contributing to risk in different ways in different individuals,» said Jones.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

For one out of 30 people with diabetes, genes are known to play a decisive role, particularly in a grouping of DNA known as maturity - onset diabetes of the young, which includes a mutation that causes the pancreas to produce less insulin.

Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «gene regulation,» the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer.

With just a bit of hindbrain and a flap of ear where the head should be, the mouse pup is a freak of science — but it is also the first proof that a single gene plays an essential role in creating a head.

Carroll: That's right and we are just understanding that there is a lot more trajectories open, so yeah, sort of a long - standing model, it was just as you said, that you sort of would keep one gene to do all the old jobs and play with the new gene, but it turns out that we are appreciating a lot more.

Hmr doesn't play well with Lhr, a D. simulans gene that also helps make sure chromosomes are doled out properly.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

When the keratinocytes treated with all six cytokines expressed significantly more genes than one of the lacking combinations, it meant that the lacking cytokine was playing an influential role for the expression of those genes.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

In a paper published recently in the Journal of Clinical Investigation, lead authors at the University of Georgia, along with colleagues from the Rensselaer and the University of California at San Diego, demonstrated for the first time that the gene NDST1 plays a significant role in the proper development of the diaphragm, and that abnormal expression of the gene could lead to CDH.

In line with this interpretation, the enzyme encoded by this gene also plays a role in producing hormones (thyroid and insulin) involved in brain development.

To see what role the genes play in spore - to - spore communication, the researchers replaced the genes of one strain with those of a different group.

In addition, treatment with Korean red ginseng extract suppressed the expression of RSV - induced inflammatory genes and the formation of chemically reactive molecules containing oxygen, which play a role in virus - induced epithelial damage in RSV.

In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez - Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection.

They further established that the protein produced by the BRCA 1 gene binds with a protein known to play an important role in the metabolism of fat in muscle cells known as Acetyl - CoA carboxylase or ACC.

«The genes we have identified are unlikely to work in isolation to cause greying or straight hair, or thick eyebrows, but have a role to play along with many other factors yet to be identified.»

Stella Man, a researcher from Queen Mary, University of London, recently discovered that Cx26, a gene associated with deafness, also plays a role in helping wounds heal.

The gene identified for grey hair — IRF4 — is known to play a role in hair color but this is the first time it has been associated with the greying of hair.

For example, higher chocolate intake and a larger waist size was associated with certain forms of the oxytocin receptor gene, and an obesity - associated gene played a role in vegetable and fiber intake.

The paper published online this month in Genetics examines a «foraging gene» humans share in common with the flies, which plays multiple roles and is found in similar places, such as the nervous system, in the muscle and in fat.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

A study carried out by the Laboratoire Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS / Aix - Marseille Université), in collaboration with clinicians from Marseilles Public Hospitals (AP - HM) and scientists from the Salk Institute in San Diego (US), has revealed a new gene that plays a crucial role during early development in humans and whose under - expression may induce certain autistic traits.

«Our findings showed that an in increase in methylation of the SKA2 gene is associated with decreased cortical thickness in the prefrontal cortex, which may play a role in the development of PTSD and may explain why this gene predicts risk for mental health problems, like PTSD and suicide,» explained lead and corresponding author Naomi Samimi Sadeh, PhD, assistant professor of psychiatry at BUSM and a psychologist in the National Center for PTSD at VA Boston.

Biologists working with the most sophisticated genetic tools are demonstrating that natural selection plays a greater role in the evolution of genes than even most evolutionists had thought

With little knowledge of the roles that the Y chromosome genes play in fertility, most animal breeders and farmers select bulls based on physical characteristics, such as the size of the testis.

Genes may come into play only in conjunction with certain environmental kicks.

«These findings suggest that GCLM polymorphisms [gene variants] that affect glutathione production also affect methylmercury retention,» she wrote to me in an e-mail, «and that GSTP1 may play a role in conjugating [chemically joining] methylmercury with glutathione.»

In addition, researchers found that the gene families related to whale's body hair and sensory receptors were contracted, such as Keratin - related gene families associated with hair formation, several Hox genes that play an important role in the body plan and embryonic development.

The next step was to find out which role Shp2 and its target genes play in human patients with breast cancer.

Fifth, the proportion of type 1 diabetics who have the susceptibility genes associated with a high risk of developing the disease is getting smaller and smaller, suggesting that genetics is playing a lesser role.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

One third of the target genes for which they had patient data - 32 out of 97 - were also linked to survival in women with oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.

So if we assay a panel of tumors and see that half the tumors have a mutation in gene A, and the other half have a mutation in gene B, with no overlap, it's quite likely that the mutations play similar functional roles.

Insight into the novel role that NMDA receptors play in retinal responses to hypoxia may be derived from study of the coordinated expression patterns of genes that interact, either directly or indirectly, with the NMDA receptor; namely, the NMDA interactome.

It is likely that modules of genes with analogous functions in various developmental contexts, e.g., grass inflorescence development, have been co-opted to link these pathways where BRs play a role.

Yamanaka and colleagues at Kyoto University started their search with 24 genes they thought might play a role.

«85 % of these genes are required for nephrocyte function, suggesting that a majority of human genes known to be associated with NS play conserved roles in renal function from flies to humans,» said Zhe Han, Ph.D., senior author of the paper and Associate Professor at the Centre for Cancer and Immunology Research at Children's National.

Study pursues the genes with which a zebrafish views its world Neuroscientist biologist Herwig Baier, PhD, UCSF assistant professor of physiology and formerly of the Max Planck Institute in Tubingen, is working to identify zebrafish genes that play a role in visual perception.

Many individual ASD patients had deletions or duplications of multiple genes within this network, but for those patients with just a single gene from the network changed, that single gene appeared to play an important role.

After concluding from our proof - of - concept experiment that a successful gesicle - based knockout of a virally integrated gene can be achieved, we chose to target CD81, an endogenous membrane glycoprotein that forms complexes with integrins and plays a critical role in the infection process that leads to hepatitis C (Figure 3).

Indeed, mutations in multiple lysosomal genes result in severe neurodegeneration and it is becoming more clear that lysosomes also play a neuroprotective role in more common neurodegenerative diseases such as Alzheimer's disease that have not traditionally been associated with lysosomal defects.