Sentences with phrase «postmortem studies of the brains»

Postmortem studies of the brains of Alzheimer's patients show a dramatic destruction of neurons, and particularly neurons which secrete or utilise the neurotransmitter acetylcholine.

Not exact matches

Specifically, intensive postmortem neurological studies of their brain tissues reveal a relatively low density of acetylcholine (a neurotransmitter) nerve sites, which, at normal densities, function in critical ways to help re-initiate breathing following a sleep - related apnea or extended breathing pauses.

A study published online last November in Brain, based on the most comprehensive collection of postmortem images compiled to date, shows that Einstein's cerebral cortex, responsible for higher - level mental processes, differs much more dramatically than previously thought from that of a person of average intelligence.

Studies have reported altered methylation patterns in postmortem brains of people with autism.

In a study reported in Nature, Collinge and colleagues found A-beta buildup in four of eight postmortem brains from people who had received growth hormone injections

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

A recent human study also indicated a genetic association of the αCaMKII gene with bipolar disorder, and decreased expression of αCaMKII has been observed in postmortem brains of patients with bipolar disorder.

However, the neural basis of early overgrowth remains unknown and can only be known from direct quantitative studies of the young postmortem autistic brain.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

In this context, Dr. Woo's work focuses on deepening the understanding of these mechanisms based on postmortem human brains and animal studies using a variety of protein and gene expression techniques, in addition to the utilization of differentiated human neurons.

Numerous studies on postmortem brains have found evidence of infection, such as biofilms, in the same regions as Alzheimer's neurodegeneration — namely, the hippocampus and temporal lobe (1).

Postmortem studies show lower than normal levels of BDNF in the brains of people with Alzheimer's.

Several postmortem studies report the presence of inflammatory markers in the brains of depressed or mood - disordered patients.

This ability makes stem cell - driven research a good complement to studies of postmortem brains.

Studies of postmortem brain tissue will lead the way to better prevention and treatment of autism spectrum and related neurodevelopmental disorders.

«With postmortem research, we're studying brain circuits and the molecules and cells that support these circuits — the potential targets of new drugs,» said Dr. Woo.

A postmortem brain study showed that the emergence of structural connectivity moved generally from posterodorsal to anteroventral regions in infants aged between 17 to 40 weeks post-conception [47].