Sentences with phrase «potential therapeutic target for»
Because increased intestinal permeability appears to be a central mechanism in the pathogenesis of NSAID enteropathy, it becomes a potential therapeutic target for prevention.
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Together, these data define METTL3 as a regulator of a chromatin - based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.
Gladstone scientists identify inflammatory pathways as a potential therapeutic target for frontotemporal dementia
They hope to identify a potential therapeutic target for Zika virus.
Previous investigations had identified hUPF1 as a potential therapeutic target for ALS, but it was unclear how this protein prevented cell death.
Nevertheless, our results indicate that miR - 7 / KLF4 axis may serve as a potential therapeutic target for brain metastasis of breast cancer, which is almost always incurable at the present time.
«Showing that TWEAK is a critical mediator in both conditions, makes it a potential therapeutic target for the treatment of inflammatory skin diseases in general.»
«Potential therapeutic target for wound - healing, cancer identified.»
The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.
Therefore, BCAR4 may be a potential therapeutic target for cervical cancers with this alteration.
This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
«Potential therapeutic target for deadly brain cancer.»
A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five - year survival rate.
This has prevented the identification of potential therapeutic targets for clinical intervention.
Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction.
Not exact matches
«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»
«Given this mechanism, ataluren offers the potential for a new therapeutic approach for multiple nonsense mutation genetic disorders by targeting the underlying cause of the disease.»
«But there is a silver lining: Sleep is now a new target for potential therapeutic intervention.»
«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.»
«Our findings present new potential targets for therapeutic regulation of cross-presentation,» said Filippo Veglia, Ph.D., first author of the study and staff scientist in the Gabrilovich Lab.
It could be a critical target with significant therapeutic potential for suppressing inflammation associated with chronic airway disease.
The role of Apelin and Elabela in establishing the circulatory system makes them potential targets in future development of therapeutic applications for illnesses ranging from the various cancers, and cardiovascular diseases, to even metabolic diseases such as diabetes.
«Our findings have important translational value since they establish this protein enzyme as a novel and viable therapeutic target with real disease - modifying potential for AD,» Praticò said.
Findings from this study provide a potential therapeutic target and offer the possibility for developing a treatment.
«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.
Moreover, this pathway, specifically GARP, may be a potential future therapeutic target for treatment.
Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
«Given the therapeutic potential of the nSMase target, we're now working closely with Drs. Barbara Slusher, Camilo Rojas, Ajit Thomas and colleagues at the Johns Hopkins Drug Discovery facility to identify potent inhibitors of the nSMase enzyme which can be developed for clinical use,» says Haughey.
But, these squishy packages are hard targets for potential therapeutic and diagnostic applications that exploit nanomaterials, from quantum dots that light up specific tissues to nanocages carrying drug payloads.
They will also map the regulatory machinery for stress granules, to seek potential therapeutic targets.
Dr. Qimin Zhan, Principal Investigator of this project and the Director of State Key Laboratory of Molecular Oncology, Chinese Academy of Medical Sciences Cancer Hospital, said, «For sure, the findings of this project provide novel insights into understanding of underlying mechanism for this malignant ESCC, and enable us to explore potential diagnostic biomarkers and drug targets, and to develop useful clinical therapeutic approachFor sure, the findings of this project provide novel insights into understanding of underlying mechanism for this malignant ESCC, and enable us to explore potential diagnostic biomarkers and drug targets, and to develop useful clinical therapeutic approachfor this malignant ESCC, and enable us to explore potential diagnostic biomarkers and drug targets, and to develop useful clinical therapeutic approaches.
An international study led by researchers at Monash University» Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.
Dr. Kirino says that «further studies to understand how SHOT - RNAs promote cell proliferation may lead to the use of SHOT - RNAs as potential target candidates for future therapeutic applications in breast and prostate cancers.»
Defining the network interactions among these modular elements (and their probabilistic relationships, where appropriate) not only will account for the ultimate pathophenotype but also can lead to the identification of potential regulatory nodes within the network that can modify phenotype (i.e., potential therapeutic target).
This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.
This study may provide a potential biomarker and therapeutic targets for glaucoma.
Finally, his discussion covers the genetic manipulation of induced pluripotent stem cells (iPSCs) to derive NK cells engineered to express modified CD16A, and their potential for improving the efficacy of tumor - targeting therapeutic mAbs.
Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and technologies with high therapeutic potential.
The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.
We further expect our results to show that RPE cell - secreted vesicles are essential for cell - to - cell communication connected to spreading RPE degeneration in AMD, and therefore, potential therapeutic targets to halt vision loss in AMD.
PrediXcan has the potential to identify gene targets for therapeutic applications faster and with greater accuracy than traditional methods.
Clinical studies conducted by Steinman have shed light on the therapeutic potential of DCs, particularly as targets for cancer vaccination.
In other words, Ras proteins naturally lack areas that are accessible, high - affinity binding targets for potential therapeutic agents.
In particular, widespread ocular diseases such as age - related macular degeneration (AMD) and retinitis pigmentosa (RP), as well as a genetic condition called Stargardt's macular dystrophy (STGD) that afflicts young people, are all potential disease targets for therapeutic approaches.
«As more of the pieces are assembled, they provide potential new targets for therapeutic agents.»
«The inflammation resolving targeted nanoparticles have shown exciting potential not only for the potential treatment of atherosclerosis as described here, but also other therapeutic areas including wound repair, for example, as described in the Feb. 9 online issue of Journal of Clinical Investigation, in addition to other applications currently underway with our collaborators,» Farokhzad said.
The goal is to test if targeting the vitamin D receptor will unlock the potential of immunotherapies to kill pancreatic cancer tumor cells and potentially establish a therapeutic combination for controlling advanced pancreatic cancer, extending patient survival, and reducing patient side effects.
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
NMNATs are potential drug targets for therapeutic interventions in neurodegeneration.