He also served as Executive Vice President for Worldwide Discovery and
Preclinical Research at Merck & Co..
Over the course of its development, PNP has secured grants from the National Institutes of Health of approximately $ 10 million to support
preclinical research at Southern Research Institute and UAB.
Targacept needs to succeed in only two of its phase III trials to gain approval, says Merouane Bencherif, head of
preclinical research at the company.
Not exact matches
Looking
at sixty - seven recent drug discovery projects based on
preclinical cancer biology
research, they found that in more than 75 percent of cases the published data did not match up with their in - house attempts to replicate.
In
preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new
research published in PLOS ONE from the Perelman School of Medicine
at the University of Pennsylvania.
• Changes may be afoot for biomedical scientists as a result of efforts
at the National Institutes of Health (NIH) to improve the reproducibility of
preclinical research.
The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility
at the Broad Stem Cell
Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical
Research Center; the use of this facility is an important step in the process as
preclinical research moves toward human clinical
research moves toward human clinical trials.
For example, Matt Krause, director of human resources
at CV Therapeutics, says, «Our
research programs include multiple, cutting - edge cardiovascular product candidates in various stages of clinical trials and
preclinical programs, all of which rely heavily on the contributions from our many B.S. - and M.S. - level scientists.»
«To better understand safety issues, we are making efforts to employ more modern investigational, molecular approaches to safety assessment — and increase our safety testing work force by about 10 percent,» says Phil Bentley, vice president and global head of
preclinical safety
at Novartis Institutes for BioMedical
Research in New York City.
The
preclinical study was led by researchers
at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove
Research Institute (OSUCCC — James).
Recently published in the journal eLife and featured in a poster session
at this year's American Association for Cancer
Research (AACR) annual meeting,
preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).
The Walter Reed Army Institute of
Research (WRAIR) and collaborators
at the Beth Israel Deaconess Medical Center and Harvard Medical School have completed a promising
preclinical study of two Zika vaccine candidates that suggests that an effective human vaccine will be achievable.
The current study is built on more than 20 years of
preclinical research on memory codes led by Sam Deadwyler, Ph.D., professor of physiology and pharmacology
at Wake Forest Baptist, along with Hampson, Berger and Song.
Scientists
at the University of California
at San Diego currently are studying MW108 in
preclinical cancer immunology
research.
Formerly a
research leader
at CHOP, High pursued groundbreaking
preclinical investigations in hemophilia B gene therapy and provided scientific expertise to previous gene therapy trials in hemophilia and other genetic disorders
at CHOP before moving to Spark Therapeutics, which was spun off from CHOP in 2013.
«The pace of
preclinical and early clinical development for Zika vaccines is unprecedented,» said Barouch, corresponding author and director of the Center for Virology and Vaccine
Research at BIDMC.
«We are
at a point in our
research where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular M
research where we have validated the efficacy of this combination treatment approach in
preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer
Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular M
Research and co-leader of the Cancer Molecular Genetics
research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular M
research program
at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine.
The Herbert Irving Comprehensive Cancer Center
at NewYork - Presbyterian / Columbia University Medical Center encompasses
preclinical and clinical
research, treatment, prevention, and education efforts in cancer.
These encouraging
preclinical results suggest the compound, known as GS - 5734, should be further developed as a potential treatment, according to
research findings to be presented tomorrow
at the IDWeek conference.
Explore our specialized
research portfolio of unique solutions to clinical and
preclinical research problems developed by experts
at Wake Forest Baptist Medical Center.
PHILADELPHIA --(July 11, 2017)-- Researchers
at The Wistar Institute, an international leader in biomedical
research in the fields of cancer, immunology and infectious diseases, with collaborators
at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a
preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).
Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics
at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics
at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the
preclinical research stage, because one animal model may not fully recapitulate the human disease.
PNP Therapeutics, Inc. — a company based on a gene - therapy technology developed by scientists
at Southern
Research Institute and the University of Alabama
at Birmingham (UAB)-- has found an approach that has abolished otherwise unmanageable human cancers in
preclinical rodent studies.
Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new
preclinical data supporting the development of microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session
at the 2018 American Association for Cancer
Research Annual Meeting (AACR) in Chicago.
Faulty mitochondria contribute to a range of diseases and a
research group working towards the use of mitochondrial donation techniques for women
at risk of passing on those diseases to their children have described their
preclinical work in the journal Nature.
Dr. Bolen will oversee all aspects of R&D
at Moderna, including discovery
research,
preclinical and clinical development, and clinical operations.
It enables scientists
at Moderna's ventures and New Venture Labs, as well as our biopharma partners, to digitally design and order mRNA constructs for use in discovery
research and
preclinical studies through an encrypted and secure portal.
Under the terms of the partnership, Moderna will sponsor
research grants for scientists
at both institutions to conduct
preclinical research with novel mRNA Therapeutics ™.
Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups,
research teams as well as pharmaceutical industry, by providing
preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population
at risk.
Gosselies, Belgium - April 3, 2017 - iTeos Therapeutics SA, a biotechnology company developing novel cancer immunotherapies, will present
preclinical data for its A2A receptor antagonist, which inhibits the immune suppressive function of adenosine,
at the American Association for Cancer
Research (AACR) Annual Meeting.
PHILADELPHIA — In
preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new
research published in PLOS One from the Perelman School of Medicine
at the University of Pennsylvania.
Jesse Erasmus is a postdoctoral scientist in the
Preclinical & Translational
Research group
at IDRI.
Thus, to support and enhance our collaborations with industry partners dedicated to improving the lives of children with nervous system disorders, the Translational Neuroscience Center (TNC)
at Boston Children's Hospital has recruited Robin Kleiman, PhD, as the head of
preclinical research.
The researchers are reporting
preclinical findings for a potential two - treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer
at the American Association for Cancer
Research Annual...
Performs genome - wide profiling of vector integration sites as readout of cell growth
at clonal level, in basic
research studies and technology development, in
preclinical safety studies and in gene therapy treated patients.
Researchers
at the Sanford Consortium for Regenerative Medicine have broad scientific goals in basic and
preclinical research, as well as
preclinical development of discoveries.
He was introduced to radiopharmaceutical development as a postdoctoral
research associate and then as a staff scientist in the department of radiology
at Washington University School of Medicine, where he developed several
preclinical imaging agents to study brain tumors, atherosclerosis and Alzheimer's disease.
Wake Forest Innovations can help you solve these medical problems by getting you access to the researchers and clinicians
at Wake Forest Baptist Medical Center to advance your
preclinical or clinical
research — from stroke and epilepsy to pain and addiction and everything in between.
The Duke Center for Integrative Health
Research (DCIHR) is a multidisciplinary center of innovative preclinical and clinical research aimed at optimizing health and well - being using methodologies based in complementary and integrative medicine, nutrition, fitness, and health behavior
Research (DCIHR) is a multidisciplinary center of innovative
preclinical and clinical
research aimed at optimizing health and well - being using methodologies based in complementary and integrative medicine, nutrition, fitness, and health behavior
research aimed
at optimizing health and well - being using methodologies based in complementary and integrative medicine, nutrition, fitness, and health behavior change.
At Vets Plus, Dr. Ajay leads new product development initiatives, overseeing all
preclinical and clinical trials and
research.