Sentences with phrase «preclinical studies of»

Preclinical studies of vaccine candidates have typically shown post-infection virologic control, but protection against acquisition of infection has previously only been reported using less rigorous viral challenges.

BACKGROUND Despite widely reported clinical and preclinical studies of rapid antidepressant actions of glutamate N - methyl - D - aspartate (NMDA) receptor antagonists, there has been very little work

Preclinical studies of the effects on this drug on neurodegeneration have been done but do not appear to have been published so I do not know which disease models were used.

Published new efficacy and safety data from preclinical studies of AST - OPC1 in the peer - reviewed journal «Stem Cells Translational Medicine.»

Together our data support the notion that targeting DGKζ, a negative regulator of T cell activation, or other regulators of Erk activation, could be useful in the treatment of human malignancy and that additional preclinical studies of intracellular «brakes» on T cell activation are warranted.

The issue of sex is particularly acute in preclinical studies of Rett syndrome, a disorder caused by mutations in a gene located on the X chromosome.

Small - animal imaging has become an important research tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

The Walter Reed Army Institute of Research (WRAIR) and collaborators at the Beth Israel Deaconess Medical Center and Harvard Medical School have completed a promising preclinical study of two Zika vaccine candidates that suggests that an effective human vaccine will be achievable.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

Not exact matches

Some retrospective studies and preclinical work have indicated that it might also lower a person's risk of cancer, though at least one clinical trial wasn't able to show that it had any protective effect on esophageal cancer.

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

Although the biotech has only conducted preclinical studies so far, there are several potential advantages to nonviral therapies, including being quicker to develop and possibly eliminating the need for a lengthy monitoring period of patients after treatment.

Through a rigorous pharmaceutical approach, Gnosis carries out a seamless flow of operations, from product concept to research and development, preclinical and clinical studies, regulatory filing and Intellectual properties, manufacturing and distribution standing alongside customers.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

A preclinical study shows that an experimental nanotechnology drug called SapC - DOPS crosses the tumor blood - brain barrier, targets brain - tumor cells and retards growth of tumor blood vessels.

«These results provide the basis for the potential implementation of 5 - LO - inhibitors as stem cell therapeutic agents for a sustained AML cure, although this must be investigated further in preclinical and clinical studies in humans,» explains Dr. Ruthardt.

«Even though they're inactivating the virus, it's still there,» says Ross, whose laboratory worked with Novavax during its preclinical studies, when the start - up was in need of laboratory facilities.

The study, «Optimizing Femoral - head Osteochondral Allograft Transplantation in a Preclinical Model,» recently was published in the Journal of Orthopaedic Translation.

Past studies have suggested depression and other neuropsychiatric symptoms may be predictors of AD's progression during its «preclinical» phase, during which time brain deposits of fibrillar amyloid and pathological tau accumulate in a patient's brain.

The new data builds off several preclinical studies supporting the use of ibrutinib with CAR therapy.

Now, a new preclinical study from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never - before - seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib.

An editorial in the same issue of the journal notes that drug - based treatments for liver cancer are limited and that the UT Southwestern study showed «truly remarkable results that should prompt further research under preclinical settings, given its potential to lead to a paradigm shift in treatment.»

The study chronicles the use of Vasalgel ™ in groups of rhesus macaques — confirming previous preclinical findings in rabbits on the efficacy of the new device and offering a new tool to colony managers.

Independent of these preclinical studies, Clementia Pharmaceuticals is currently conducting phase 2 clinical trials in individuals with FOP, based on the 2011 preclinical results published by Pacifici and Iwamoto.

Elizabeth Pollitzer comments on the under - representation of women in preclinical, clinical and epidemiological studies (8 February, p 30).

Study leader Robert Darnell, a Howard Hughes Medical Institute (HHMI) investigator at the Rockefeller University, calls the findings «an exciting step toward a different kind of treatment approach,» but cautions that the results, from studies of mice, are preclinical.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

The preclinical study looked at the effect of DHA on lupus lesions in the lungs and kidneys of female mice that were already genetically predisposed to the disease.

«Preclinical studies suggested that this combination therapy would have better outcomes than those elicited by their individual or sequential administration,» said Hodi, who is also director of the Melanoma Center at the Dana - Farber Cancer Institute.

«The novelty of this study is two-fold: We used a preclinical prevention paradigm of a CRF - antagonist (a drug that blocks the CRF receptor in brain cells) called R121919 in a well - established AD model — and we did so in a way that draws upon our experience in human trials.

Rice graduate student Lifeng Yang, lead author of the study, designed a preclinical experiment to test the feasibility of a multidrug approach.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

«Future studies will aim to explore the relationship between SND1 and STAT3, identify additional microRNAs that may be relevant to malignant glioma and explore the effects of drugs that block SND1 expression in more advanced preclinical models.»

Preclinical studies suggest that Cdk5 is a gene that is important for the normal wiring of the brain during early development and may be involved in some neurodegenerative disorders, including ALS, Parkinson's and Alzheimer's disease.

In a study of preclinical models of colorectal cancer, the researchers identified an underlying mechanism for the activation of p53 by FL118.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

The current study is built on more than 20 years of preclinical research on memory codes led by Sam Deadwyler, Ph.D., professor of physiology and pharmacology at Wake Forest Baptist, along with Hampson, Berger and Song.

Preclinical animal models are available that will facilitate the study of these important interactions to advance our knowledge, so that the obesity - and diabetes - driven burden of PDAC can be curbed,» commented Dr. Eibl.

The Pilot Bioproduction Facility headed by Dr. Kenneth H. Eckels, produced small batches of vaccine candidates that were used for the preclinical studies and is currently manufacturing a vaccine lot for use in initial human clinical studies.

«Preclinical studies suggest a possible benefit of estrogen therapy when combined with exercise to increase strength and performance and to prevent the loss of muscle mass, but the role of estrogen in muscle mass is not yet clear for postmenopausal women,» says Dr. JoAnn Pinkerton, executive director of NAMS.

Scientists at the University of California at San Diego currently are studying MW108 in preclinical cancer immunology research.

If these preclinical studies are successful, the researchers plan to further develop their CAR T cell therapy and test its safety and efficacy for different types of metastatic cancer in upcoming clinical trials.

The findings of multiple in vivo preclinical studies published online in Blood Advances, a Journal of the American Society of Hematology (ASH), indicate that this therapy could potentially treat multiple cancers, including non-Hodgkin lymphoma (NHL), multiple myeloma (MM), and acute myeloid leukemia (AML).

A preclinical study led by researchers in the United States has found that a new oral drug shows early promise for the treatment of muscular dystrophy.

The study, which lays the foundation for future preclinical work, appears June 14 in Stem Cell Reports, a publication of the International Society for Stem Cell Researchers.

The study, funded by the NIH / NIAAA, also demonstrates the great potential value of preclinical studies for understanding human disorders.

According to a recent study of Framingham Study participants, nearly 60 percent of people have prevalent preclinical heart failure (HF) stages A and B. Heart failure occurs when the heart muscle is weakened and can not pump enough blood to meet the body's needs for blood and oxstudy of Framingham Study participants, nearly 60 percent of people have prevalent preclinical heart failure (HF) stages A and B. Heart failure occurs when the heart muscle is weakened and can not pump enough blood to meet the body's needs for blood and oxStudy participants, nearly 60 percent of people have prevalent preclinical heart failure (HF) stages A and B. Heart failure occurs when the heart muscle is weakened and can not pump enough blood to meet the body's needs for blood and oxygen.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.