Preclinical models demonstrated that CTLA - 4 blockade could augment anti-tumor response [12].
Not exact matches
«This study for the first time shows increased expression of IL - 33 in AMD and further
demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in
preclinical models of retina stress,» the authors note.
NeuroPhage has accumulated extensive
preclinical data on this candidate,
demonstrating its efficacy across disease
models of Alzheimer's and Parkinson's disease, tauopathies and other related diseases characterized by aggregation of amyloid beta, tau, and alpha - synuclein proteins.
iTeos is now developing EOS200271 which is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), which has
demonstrated the same anti-tumour activity in multiple
preclinical tumour
models in combination with immune checkpoint inhibitors as competitors, but also has
demonstrated superior brain penetration.
EOS200271 has
demonstrated anti-tumor activity in multiple
preclinical tumor
models in monotherapy and in combination with immune checkpoint inhibitors.
«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «
Preclinical models have
demonstrated a critical role for autophagy in multiple cancer types.»
This proof - of - concept study used
preclinical models to
demonstrate that the device was effective in reducing the cancerous tumour in the living brain.