Sentences with phrase «predictive biomarkers of»
Predictive biomarkers of response are becoming increasingly important in the development of effective clinical trials of targeted therapies.»
https://www.sciencedaily.com/
«In the preplanned biomarker analysis, the expression of pSTAT3 detected by immunohistochemistry was both a prognostic marker and a predictive biomarker of benefit from napabucasin,» the researchers wrote.
Not exact matches
As a Genentech spokesperson told me at the time: «Despite looking at hundreds of potential predictive biomarkers, we do not currently have a way to predict who is most likely to respond to Avastin and who is not.»
Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.
«Biomarker predictive of NSCLC response to drug.»
«We now have developed a better panel of biomarkers that are predictive across several psychiatric diagnoses.
The team's next avenue of research will be focused on identifying a «biomarker» that can identify this distinct suppressive cell elsewhere in the body — for example, in blood or other samples — as a potential predictive clinical tool to determine when these cells are present in patients, which currently can not be done.
In efforts to enhance pre-clinical drug testing, Thomas Gaddy of the University of Southern California, Los Angeles, and colleagues in the research group of Professor Stacey Finley investigated a potential predictive biomarker for a type of cancer drug known as anti-angiogenic therapy.
In Europe, the legislation for marketing of medicinal products (MP) and IVDs including predictive biomarker - based assays (Companion Diagnostics, CDx) are not directly linked which is challenging for co-development.
His research interests include new therapies, predictive biomarkers, cancer survivorship, and quality of care.
GeneAssess, Inc., is dedicated to developing its breakthrough discovery of the FRY gene as a predictive biomarker for breast and other cancers.
The overall goal of this study is to improve knowledge of the mechanism of HPV carcinogenesis and discover potential biomarkers in the vaginal microbiome predictive or protective of persistent HPV infection through interrogation of vaginal microbiota in a well phenotyped, homogenous cohort of Asian women.
Furthermore, such multi-omics approaches can identify early signatures / biomarkers predictive of magnitude, quality and / or duration of vaccine - induced adaptive immune responses.
Biomarkers predictive of disease phenotype will be validated using existing, publicly available studies by deciphering microbiome characteristics and commonalities associated with healthy and disease states.
BPRC is also involved in the development of assays and biomarkers for the predictive value of animal models in vaccine evaluation.
Major focus areas include human genome interpretation and genetic dissection of novel rare diseases, predictive genomic signatures of response to therapy — especially cancer therapy, and novel sequencing - based assays as biomarkers of disease.
Other areas of research include designing novel therapies based on molecular pathways and identifying predictive biomarkers in patients to design personalized, targeted therapies.
Sexual dimorphism is also evident in the expression and the predictive value of some fat - related biomarkers (16, 41, 42).
The mission of the Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM) is to improve human health by conducting basic and translational research that leads to the development of effective diagnostic biomarkers, vaccines, antivirals and therapeutics for emerging, re-emerging, neglected or rare infectious diseases.
Christina's research leverages genome - scale data, coupled with computational modeling and iterative experimentation in order to define the molecular determinants and dynamics of tumor progression and to develop predictive and prognostic biomarkers.
Biomarkers that correlate with AD polygenic risk score, a measure of the polygenic architecture of the disease and highly predictive of AD status, would be excellent candidates.
In addition, they integrate their research objectives with those of the Biomarker Sciences Program committees to incorporate predictive / prognostic molecular and imaging biomarkers into therapeutic trials, whenever possible.
We are actively seeking a set of patient data that we can use to validate the biomarkers we have identified so we can create a comprehensive predictive model of response to allow us to better tailor treatment.»
Although cancer immunotherapy is changing the paradigm of how cancer is treated, there is an urgent need to develop predictive biomarkers to identify patients who are most likely to benefit from various immunotherapeutic strategies.
Our approach to achieving this goal focuses on three objectives: (1) to develop a reliable, predictive panel of biomarkers (including both biological and bio-behavioral measures) that can identify children, youth, and parents showing evidence of toxic stress, and that can be collected in pediatric primary care settings; (2) to conduct basic, animal and human research on critical periods in development and individual differences in stress susceptibility, thereby informing the timing and design of a suite of new interventions that address the roots of stress - related diseases early in the life cycle; and (3) to build a strong, community - based infrastructure through which scientists, practitioners, parents, and community leaders can apply new scientific insights and innovative measures to the development of more effective interventions in the first three postnatal years.
Significant improvements in patient care will require identification of new biomarkers that are predictive of clinical behavior.
Batteries of biomarkers that measure allostatic load (also termed allostatic overload to highlight pathophysiology of the extreme)(38) tap into the major mediators of allostasis along with some key secondary outcomes, such as body mass index or waist — hip ratio and glycosylated hemoglobin (39), and provide a broad - based assessment of the dysregulation of these adaptive systems that has turned out to have predictive value in a variety of epidemiologic studies (40).
Molecular biomarkers predictive of sertraline treatment response in young children with fragile X syndrome.