Sentences with phrase «problems during clinical trials»

Patients from the U.S. and Europe filled out questionnaires called the «Work Productivity and Activity Index — Specific Health Problems During Clinical Trials of LDV / SOF.»

Not exact matches

Fortunately, conducting randomized trials over the decades, intervention researchers have produced numerous manual - guided, evidence - based treatments (EBTs) for depression, anxiety, and conduct in youth.2 Unfortunately, these treatments have not been incorporated into most everyday clinical practice.3 - 5 A common view is that the complexity and comorbidity of many clinically referred youths, whose problems and treatment needs can shift during treatment, may pose problems for EBT protocols, which are typically designed for single or homogeneous clusters of disorders, developed and tested with recruited youths who differ from patients seen in everyday clinical practice, and involve a predetermined sequence of prescribed session contents, limiting their flexibility.3 - 8 Indeed, trials testing these protocols against usual care for young patients in clinical practice have produced mixed findings, with EBTs often failing to outperform usual care.7, 9