Sentences with phrase «progenitor cell transplants»

Human Embryonic Stem Cell - Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery After Cervical Spinal Cord Injury.

Not exact matches

The enhanced mice masterfully memorized new objects, swiftly learned to link certain sounds or situations to an unpleasant foot shock, and displayed un-usually savvy maze navigation — signs of mental acuity that surpassed skills exhibited by either typical mice or mice transplanted with glial progenitor cells from their own species.

They then transplanted progenitors of the inner ear cells into the inner ear of embryonic normal and Connexin 30 knockout mice using glass tubes with optimized tip sizes.

For the other adult patients that might still benefit from a cord blood donor, either two cord blood units are combined for a single transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or progenitor cells in the laboratory before infusion or modify the cells in some way to make them more potent at the time of transplant.

Dr. Viczian has demonstrated that a single extrinsic factor can transform frog skin cells into retinal stem / progenitor cells and, further, that the newly made cells could generate an entire functional eye once they were transplanted to host embryos.

In addition, when these inhibitory progenitor cells were transplanted into apoE4 mice with an accumulation of amyloid beta, prior deficits were alleviated.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson's disease.

In the CNS, transplanted human neural progenitor cells derived from prenatal cortex (hNPCctx) display characteristics important for cell - based rescue of degenerating neurons.

(C) Confocal image of P150 dystrophic inner retina transplanted with hNPCctx — GDNF and double stained with antibodies against nestin, a neural stem and progenitor cell marker (green) and human nuclear antigen (red).

Further challenges include the identification of signaling molecules that promote the generation of beneficial populations of astrocytes, identification of appropriate stem and / or progenitor cell populations that can be the source of such cells, and determination of whether there are situations in which it is more useful to transplant astrocytes themselves rather than to transplant stem or progenitor cells that might generate astrocytes in vivo in response to signals present in the host environment.

By transplanting Wnt - activated hematopoietic stem and progenitor cells (HSPCs) we demonstrated that Muller cells can be reprogrammed in vivo after fusion with HSPCs.

Writing in Journal of Immunology, lead author and BSI member, Professor Graham Anderson explains, «Post-transplantation, T - cell progenitors derived from the bone marrow transplant can struggle to enter the thymus, as if the doorway to the thymus is closed.

The authors transplanted human cortical ‐ derived neural progenitor cells engineered to secrete glial cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the cells migrated, matured into astrocytes, and released GDNF.

The researchers then transplant these progenitor cells into the hippocampi of mice that carry the apoE4 gene and model aspects of Alzheimer's disease.

These cells return to a precursor stage following their spontaneous fusion with transplanted haematopoietic stem and progenitor cells in damaged retinas.

In preliminary studies, they found that the transplanted progenitor cells replenish the pool of inhibitory neurons and even improve learning and memory in the mice.