Sentences with phrase «protein gene transcription»

Novel Isoforms of Heat Shock Transcription Factor 1, HSF1?a and HSF1?ß, Regulate Chaperone Protein Gene Transcription.

Not exact matches

We can compare the diverse tasks performed by a colony to the many proteins generated by gene transcription, to various cell types of a developing embryo, or to the firing patterns of neurons in the brain.

Transcription factors are proteins that «turn on and turn off» genes.

Adding seven transcription factors — proteins that switch on genes — the team then converted the IPSCs into immature HSC - like cells.

The ATF6 protein is a transcription factor, meaning it helps turn other genes «off» or «on,» depending on what's needed by the cell.

The gene encodes a transcription factor, a protein that in this case binds to DNA and allows it to be read out as messenger RNA.

Other therapies might slow gene transcription so cells make less ApoE protein to begin with.

He adds that the abundance of transcripts that overlap each gene suggests that the very term «gene» should mean something different inside the cell nucleus, where transcription takes place, than outside of it, where finished proteins go.

Project members also catalogued sequences that mark areas where DNA unwinds from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.

They noted that Tregs generally had high levels of a protein called Helios, a transcription factor that helps switch genes on and off.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

The guilty protein is beta - catenin, a transcription factor which activates other genes.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

In the paper, the researchers illustrate how it could influence proteins that activate the transcription factors that transcribe major bone - related genes to drive bone formation — showing a link between metabolite usage and activation of transcription factors.

Transcription - factor genes code for proteins that regulate the activity of other genes and so affect an animal's ability to respond to its environment.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated near the gene under their control.

Histones are proteins vital for gene regulation, and histone modifications are central to regulation of many chromosome - related processes, including DNA replication, transcription and repair.

Transcription factors are proteins that interact with DNA to turn genes on or off.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

PRMT5 (protein arginine methyltransferase 5) is an enzyme that alters the structure of chromatin to suppress the transcription of genes and the production of proteins.

During this time, transcription — the conversion of gene «recipes» encoded in DNA to mRNA, the messenger that carries the recipe to the cell's protein - making machinery — is completely shut off.

Based on previous work, the researchers had reason to think it was controlled by transcription factors — proteins that control the expression of certain genes by binding to DNA at specific locations to induce (or block) the transcription of information from DNA to RNA.

Unlike most proteins, those with these special domains can actually bind to DNA and act as transcription factors — telling specific genes to turn on or off.

They tested their system on a pair of yeast transcription factors and used the data to predict which yeast genes the proteins would target, they report in this week's Science.

Genes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other gGenes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other genesgenes.

All of these genes code for transcription factors, which are proteins that control the expression of other genes.

Here, we present evidence of widespread divergent transcription at protein - encoding gene promoters.

In their research, Pugh and Venters set out to identify the precise location of the beginnings of transcription — the first step in the expression of genes into proteins.

The researchers show that, when ethylene is perceived, transcription of certain genes that function as circuit breakers of ethylene signaling occurs, but protein production becomes restricted until ethylene is removed.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

These include proteins which control important processes in the cells, for example the transcription factors which activate genes for the production of new proteins.

The Rutgers scientists show that the transcription activator protein functions by binding to a specific DNA sequence preceding the target gene and making adhesive, Velcro - like interactions with RNA polymerase that stabilize contacts by RNA polymerase with adjacent DNA sequences.

They also show how the transcription activator protein helps RNA polymerase bind to the DNA helix at a specific site preceding a gene, and how the transcription activator protein helps RNA polymerase unwind the DNA helix to initiate transcription of the gene.

Researchers have ignored these noncoding RNAs until recently for not complying with the central dogma of biology — that a straight line runs from gene to RNA (transcription) to protein (translation).

The proteins in turn are the workhorses of biology, spurring chemical reactions inside cells and controlling the expression, transcription, and replication of the genes themselves.

At that point, a particular type of protein called a transcription activator can kick - start the molecular process by which a gene gets turned on.

Only some of the plant's 30,000 genes are active in a given root cell at a given time, thanks to proteins called transcription factors that turn genes on and off as needed.

The researchers led by Prof. Mihaela Zavolan and Prof. Anne Spang, both at the Biozentrum of the University of Basel, have discovered how the transcription factor Gcn4, a protein that regulates the expression of many genes, extends the life of baker's yeast Saccharomyces cerevisiae.

«We found that MYSM1 creates access to proteins that enhance gene transcription and, ultimately, the maturation of natural killer cells themselves,» said Vijayalakshmi Nandakumar, a Ph.D. student at the Keck School of Medicine of USC and the study's first author.

The gene codes for a type of protein called a transcription factor.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

The switch, in turn, is flicked on by proteins called transcription factors, which activate certain genes in response to certain stimuli.

Imagine the consequences if some of those piddly nucleotide changes arose in a protein that happened to be a transcription factor: Suddenly, instead of activating 23 different genes, the protein might charge up 21 or 25 of them — or it might turn on the usual 23 but in different ratios than normal.

It is situated just next to a thyroid - specific transcription factor, a protein that regulates the rate of gene expression in the thyroid.