Sentences with phrase «pymt control»
Additionally, they examine MMTV - PyMT control or POSTN null mice to test the effect of POSTN on primary tumor growth and metastasis (Figures 3A, 3B, and S13; Malanchi et al., 2012).
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Breed MMTV - PyMT + / tg; Postn + / − or MMTV - PyMT + / tg; Postn − / − male mice with Postn + / + and Postn − / − female mice to obtain MMTV - PyMT + / tg; Postn + / + control and MMTV - PyMT + / tg; Postn − / − experimental female mice, respectively.
The functional necessity of POSTN was investigated by observing the pulmonary metastatic potential in POSTN - knockout MMTV - PyMT mice, which showed a statistically significant decrease compared to controls (Malanchi et al., 2012).
c. For generation of the MMTV - PyMT + / tg; Postn + / + control female mice, the MMTV - PyMT + / tg; Postn + / − male mouse will be crossed to Postn + / + female mice to obtain MMTV - PyMT + / tg; Postn + / + male mice that will then be crossed with Postn + / + female mice.
The first experiment is to measure metastatic lung cancer in MMTV - PyMT transgenic mice crossed with the POSTN Knock out mice, and controls, with focus on the role of periostin in metastatic progression.