Sentences with phrase «raf kinase inhibitors»
The next step for CNIO, which has been running a drug - discovery program since 2005, would be to look for c - RAF kinase inhibitors as potential cancer drugs.
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The Raf ‐ 1 kinase inhibitor protein participates in the pathogenesis of IL ‐ 17 ‐ mediated autoimmune diseases and inflammation by promoting the formation of the IL ‐ 17RA ‐ Act1 complex, required for downstream signaling and cytokine production.
Moreover, these ATP - competitive inhibitors induce the formation of B - RAF and C - RAF dimers, leading to extracellular signal — regulated kinase (ERK) activation in diverse cancer cell types (23).