Sentences with phrase «rgc axon»

Our approach is innovative in that we propose to study a novel group of bioinformatically - predicted factors, which we hypothesize cooperate in controlling RGC axon growth and regeneration.

Misrouting has been attributed to the absence of the directional cues required for normal RGC axon guidance.

Some RGC axons grew all the way back to the brain's visual - processing areas.

The study, published in Nature Neuroscience in August, builds on recent research where neuroscientists got RGC axons to regrow only slightly.

In mice heterozygous for tau - lacZ targeted to the melanopsin gene locus, β - galactosidase — positive RGC axons projected to the SCN and other brain nuclei involved in circadian photoentrainment or the pupillary light reflex.

Similar paths are taken by RGC axons exiting ectopic eyes generated by transplantation of eye primordia [13]--[15].

(F) YFP expression is detected throughout the eye, in RGC axons (arrowhead) and forebrain (arrow).

We observed YFP - labeled processes exiting the induced eye at the optic nerve head that followed the expected trajectory of RGC axons to their tectal targets (Figure 4E).

We will leverage state - of - the - art bioinformatic and biological approaches for investigating how these factors interact in combination to regulate axon growth during RGC development and test the potential of such factors for regenerating RGC axons in a rodent model of optic nerve injury.

We aim to close this gap by implementing a novel assay to simultaneously assess the integrity of the axonal cytoskeletal structure (using electron microscopy) and a functional (physiological) correlate of healthy cytoskeletal structure, namely active axon transport, within individual RGC axons at an early stage of experimental glaucoma.

Project: Pathophysiological Progression in Single RGC Axons Following Microscale Compressive Injury

Identifying factors that regulate directional growth of regenerating RGC axons to their targets will provide invaluable information on developing future therapies to repair degenerated optic nerve following glaucoma.

Despite this generally well - accepted idea for how high eye pressure may affect RGC axons, scientists still do not understand the injury mechanisms involved in sufficient detail to begin identifying potential therapeutic targets.

(2007) Pressure - induced Retraction of RGC Axons in an ex vivo Preparation of Rat Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4356).

(2007) Shrinkage and Loss of RGC Axons in a New Latex Bead Rat Model of High - Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 2878).

Not exact matches

The combination prompted the regrowth of axons — the «telephone wires» that help neurons communicate — projecting from retinal ganglion cells (RGCs).

They observed that those reactive astrocytes formed quickly after axons were severed, but that neutralizing TNF - alpha, IL -1-alpha and C1q with antibodies to these three substances prevented A1 formation and RGC death in the animals.

In another experiment, the researchers severed rodents» optic nerves — an act ordinarily lethal to RGCs, whose outgoing fibers, called axons, constitute the optic nerve.

We will use molecular, histological, calcium imaging and electrophysiological methods to characterize the sensitivity of these channels to membrane stretch by mimicking the effect of IOP on RGC perikarya and axons.

When retinal ganglion cell (RGC) axons are injured, before completely degenerating, they exhibit a phase during which their internal «skeletal» structure (normally consisting of a highly organized arrangement of fibers) becomes disorganized.

My research is focused on the pathophysiology of retinal ganglion cell (RGC) axon damage in glaucoma and detecting early - stage abnormalities by means of non-invasive imaging, psychophysical testing and electrophysiological measures such as electroretinography (ERG) and visually evoked cortical potentials (VEP).

Summary: Poor regeneration and reconnection of retinal ganglion cell (RGC) axons is a major obstacle for treating ocular trauma and diseases including glaucoma.