Now researchers have found how
RNA editing helps turn overheated male embryos into females (SN Online: 6/14/17).
Not exact matches
The gene -
editing success appears to be largely due to one procedural change: The researchers introduced the
editing system — the enzyme Cas9 and a guide
RNA sequence that
helps the
editing machinery find its target — at the same time they injected the mutation - laden sperm into a healthy egg in the lab.
In CRISPR - Cas9 gene
editing, a guide
RNA sequence (green)
helps Cas9 protein (purple) cut DNA at the correct spot.
Ragsdale feels
RNA editing may
help them navigate what are often lonesome, fleeting lives.
What's more, such extensive
RNA editing seems to have
helped to minimize changes in the cephalopod DNA over the eons that they have been around.
Our goal is to
help scientists who want to use this technology for gene
editing by summarizing current advances on many technical aspects, from the
RNA guide optimized design to the genotyping analysis and the validation of the newly generated models.